Method for extracting total flavonoid active part from Huai chrysanthemum and application of total flavonoid active part

A technology of effective parts and total flavonoids, applied in the field of medicine

Inactive Publication Date: 2013-07-31
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no oral preparation for the treatment or prevention of allergic diseases such as atopic dermatitis, allergic rhinitis, etc.

Method used

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  • Method for extracting total flavonoid active part from Huai chrysanthemum and application of total flavonoid active part
  • Method for extracting total flavonoid active part from Huai chrysanthemum and application of total flavonoid active part

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Add a 20% ethanol solution 8 times the weight of the full-shaped flower of Chrysanthemum chrysanthemum, reflux and extract twice, each time for 1.5 hours, filter, combine the filtrates, recover under reduced pressure until there is no alcohol smell, and freeze-dry to obtain the chrysanthemum chrysanthemum extract. The extract was diluted 8 times with water to obtain a loading solution. The sample solution was passed through an adsorption column filled with D101 macroporous resin, eluted with 6 times the amount of 70% ethanol, the solvent was recovered under reduced pressure, and the 70% ethanol eluate was obtained by freeze-drying. The eluate was diluted with 40% ethanol to 5 times the amount, passed through the adsorption column of D101 macroporous resin, eluted with 6 times the amount of 70% ethanol, and the solvent was recovered under reduced pressure to obtain a thick paste, which was dried to obtain a total flavonoid content of 65.1 % (UV method measurement) dry pa...

Embodiment 2

[0049] Add a 20% ethanol solution 10 times the weight of the full-shaped flower of Chrysanthemum chrysanthemum, reflux and extract twice, each reflux time is 1.5 hours, filter, combine the filtrates, recover under reduced pressure until there is no alcohol smell, and freeze-dry to obtain the chrysanthemum chrysanthemum extract. The extract was diluted 6 times with water to obtain a loading solution. The sample solution was passed through the adsorption column filled with HP-20 macroporous resin, rinsed with 6 times the amount of 25% ethanol until the effluent was colorless, then eluted with 6 times the amount of 70% ethanol, and depressurized The solvent was recovered and freeze-dried to obtain 70% ethanol eluate. The eluate was diluted with 40% ethanol to 6 times the amount, passed through the adsorption column of HP-20 macroporous resin, eluted with 6 times the amount of 70% ethanol, and the solvent was recovered under reduced pressure to obtain a thick paste, which was drie...

Embodiment 3

[0051] Add 20% ethanol solution of 12 times the weight of the full-shaped chrysanthemum chrysanthemum flower, heat reflux extraction twice, each reflux time is 1.5 hours, filter, combine the filtrate, recover under reduced pressure until there is no alcohol smell, and freeze-dry to obtain the chrysanthemum chrysanthemum extract. The extract was diluted 5 times with water to obtain a loading solution. Flow the sample solution through the adsorption column filled with AB-8 macroporous resin, rinse with 6 times the amount of 30% ethanol until the effluent is colorless, then elute with 6 times the amount of 70% ethanol, and depressurize The solvent was recovered and freeze-dried to obtain 70% ethanol eluate. The eluate was diluted with 30% ethanol to 5 times the amount, passed through the adsorption column of AB-8 macroporous resin, eluted with 6 times the amount of 75% ethanol, and the solvent was recovered under reduced pressure to obtain a thick paste, which was dried to obtain...

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Abstract

The invention belongs to the technical field of medicines and relates to a method for extracting a total flavonoid active part from Huai chrysanthemum and application of the total flavonoid active part. The total flavonoid active part is prepared by the steps of extracting, filtering, adsorbing, concentrating, readsorbing and the like. In the method, toxic organic solvents are not used, so the environment is not polluted; and an adsorption and separation technique for adsorbing materials is adopted on the basis of the conventional water-containing solvent extraction method, so time consumption is little, efficiency is high, the extraction process is simple, cost is low, industrialized production can be performed, and the environment-friendly requirement is met. The total flavonoid active part extracted by the method can be applied to preparing medicines for treating or preventing allergic diseases such as atopic dermatitis, allergic rhinitis and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a method and application of extracting effective parts of total flavonoids from chrysanthemum chrysanthemums, in particular to a method for extracting effective parts of total flavonoids from full-shaped flowers of chrysanthemum chrysanthemums, and the effective parts are used in the preparation, treatment or prevention of allergies Drugs for allergic diseases such as rhinitis, dermatitis and asthma. Background technique [0002] Nowadays, the accelerated pace of life, the increase of work pressure and mental pressure make people prone to fatigue, physical decline, and susceptibility to various seasonal epidemic diseases. Due to global warming, the number of pollen in the air has increased. These all make people vulnerable to allergens, leading to an increase in the incidence of allergic diseases such as bronchitis, allergic rhinitis, hay fever, etc., posing a threat to people's ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/287A61P11/02A61P11/06A61P17/00A61P37/08A61K133/00
Inventor 袁丹王瑞杰王岩谢媛媛张琳
Owner SHENYANG PHARMA UNIVERSITY
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