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Anti-cancer medicinal composition

A technology of anti-cancer drugs and compositions, applied in the direction of drug combinations, anti-tumor drugs, active ingredients of heavy metal compounds, etc., can solve problems such as inappropriateness, and achieve the effects of low toxicity, convenient use, and significant effects

Active Publication Date: 2012-01-11
鲁南新时代生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Considering the side effects caused by dose stacking, the technical scheme of co-administering docetaxel and oxaliplatin is not appropriate

Method used

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Effect test

Embodiment 1

[0019] Embodiment 1 pharmaceutical composition microemulsion preparation of the present invention

[0020] components

[0021] Preparation process: Weigh peppermint oil, polyoxyethylene-23-lauryl ether, and 1,2-propylene glycol in the prescribed amount, mix and stir evenly, then add arctigenin and carboplatin to dissolve, and ultrasonic treatment can also be used to speed up the dissolution. The clarified concentrate is arctigenin and carboplatin microemulsion concentrate. The particle size was measured by a laser particle size analyzer, and the average particle size was 15nm.

Embodiment 2

[0022] Embodiment 2 pharmaceutical composition microemulsion preparation of the present invention

[0023] components

[0024] Preparation process: Weigh the prescription amount of spearmint oil, decaglycerol monostearate, and 1,2-propanediol, mix and stir evenly, then add arctigenin and oxaliplatin to dissolve, and ultrasonic treatment can also be used to speed up the dissolution. The clarified concentrated solution is the arctigenin and oxaliplatin microemulsion concentrate. The particle size was measured by a laser particle size analyzer, and the average particle size was 15nm.

Embodiment 3

[0025] Embodiment 3 pharmaceutical composition microemulsion preparation of the present invention

[0026] components

[0027] Preparation process: Weigh the prescription amount of peppermint oil, caprylic ethyl oleate, 1,2-propylene glycol, polyethylene glycol 8000, mix and stir evenly, then add arctigenin and picoplatin to dissolve, and ultrasonic treatment can also be used to accelerate the dissolution , to obtain a clear concentrate, which is arctigenin and picoplatin microemulsion concentrate. The particle size was measured by a laser particle size analyzer, and the average particle size was 40nm.

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Abstract

The invention belongs to the field of medicines, and particularly relates to an anti-cancer medicinal composition. The composition comprises arctigenin and a platinum anti-cancer medicament, wherein the platinum medicament is carboplatin, picoplatin or oxaliplatin. Compared with a single medicine, the medicinal composition has a synergistic effect in the aspect of inhibiting non-small cell lung cancers.

Description

technical field [0001] The invention relates to an anticancer drug composition, in particular to an anticancer drug composition containing arctigenin and platinum drugs. Background technique [0002] At present, cancer is one of the major diseases that seriously affect human health and threaten human life. Together with cardiovascular and cerebrovascular diseases and accidents, cancer constitutes the top three causes of death in all countries in the world today. Therefore, the World Health Organization and the health departments of governments of various countries have listed conquering cancer as a top priority. There are three main ways to treat cancer in the world. One is to use surgical resection to remove the diseased tissue to prevent the spread of cancer cells; the other is to use chemotherapy or radiotherapy to kill cancer cells; the third is to use drugs to treat it. Adopt the method for surgical excision to increase patient's misery, hurt its vitality, and expense...

Claims

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Application Information

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IPC IPC(8): A61K31/555A61K31/365A61K31/282A61P35/00
Inventor 赵志全姚景春
Owner 鲁南新时代生物技术有限公司
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