High-performance film coating premix capable of covering peculiar smell, and preparation method thereof

A technology of coating premix and film coating, which is applied in the direction of pharmaceutical formulation, drug delivery, etc., can solve problems such as irritating odor, and achieve the effect of reducing permeability

Inactive Publication Date: 2012-01-25
连云港康力特药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims at the defect that traditional Chinese medicine tablets and health product tablets have more or less unacceptable pungent s

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0019] A kind of preparation method of the film coating premix of high performance masking peculiar smell, comprises the following steps:

[0020] (1) Weigh one by one 30-60% of hydroxypropyl methylcellulose, 10-20% of polyacrylic acid resin, 10-20% of polyethylene glycol, 15-20% of ethyl cellulose, flow aid 10-20% coloring agent, 20-40% coloring agent, and 0.5-2% masking agent.

[0021] (2) Add the weighed materials into a high-speed shearing machine, and shear the mixed materials at a low speed of 500r / m for 15 minutes to make the materials preliminarily mixed.

[0022] (3) Increase the rotating speed to 1500r / m and continue shearing the materials for 15-25 minutes, so that the materials are fully embedded, the colorant is fully dispersed, and the finished coating premix is ​​obtained.

[0023] When the present invention is implemented, the coating premix is ​​formulated into a solution with an applicable solvent, and a film with uniform thickness is prepared by casting and...

Embodiment 1

[0024] Embodiment 1: hydroxypropyl methylcellulose 50%, polyacrylic acid resin IV No. 10%, ethyl cellulose 15%, polyethylene glycol 6000 10%, talcum powder 10%, titanium dioxide 10%, color lake 9 %, masking agent 1%.

Embodiment 2

[0025] Embodiment 2: hydroxypropyl methylcellulose: 45%, polyacrylic resin IV No. 15%, ethyl cellulose 17%, macrogol 6000 10%, talcum powder 10%, titanium dioxide 10%, color lake 9%, masking agent 1%.

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Abstract

The invention provides high-performance film coating premix capable of covering peculiar smell and a preparation method thereof, belongs to the technical field of pharmaceutical excipient production, and solves the defects that Chinese medicinal tablets and health care product tablets have unacceptable pungent smell in the prior art. The high-performance film coating premix mainly comprises hydroxypropyl methyl cellulose, ethyl cellulose, polyacrylic resin, and polyethylene glycol; the hydroxypropyl methyl cellulose has a particularly low viscosity level, the polyacrylic resin is one or more of polyacrylic resin No.IV resin, and the polyethylene glycol is polyethylene glycol 400, polyethylene glycol 4000, polyethylene glycol 6000 or polyethylene glycol 8000; and flow aid is one or two of silica or magnesium stearate and the like, and a coloring agent is one or more of various color lake or ferric oxide, and natural essence is one or more of hawthorn essence, orange essence, apple essence and the like. The high-performance film coating premix is mainly used for Chinese medicinal tablets and health care product tablets.

Description

technical field [0001] The invention relates to a film coating premix, in particular to a film coating premix with high performance for masking peculiar smell and a preparation method thereof. Background technique [0002] With the wide application of film coating technology, it is an inevitable trend to use film coating for traditional Chinese medicine tablets and health product tablets. Compared with western medicine tablets, traditional Chinese medicine tablets and health care products tablets have more or less unacceptable pungent odors because they contain Chinese medicinal materials or special ingredients with health care functions. Therefore, for the coating premix used for the coating of traditional Chinese medicine tablets and health care tablets, improving the odor masking performance of the product has been pushed to a prominent position and is constantly being challenged. [0003] Many scholars have conducted a lot of research on improving the odor-masking perfo...

Claims

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Application Information

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IPC IPC(8): A61K9/36
Inventor 刘明根
Owner 连云港康力特药业有限公司
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