The invention provides compound sodium fructose diphosphate and fructose orally disintegrating tablets. The compound sodium fructose diphosphate and fructose orally disintegrating tablets are prepared from the following ingredients in percentage by weight: 10-60% of sodium fructose diphosphate, 5-30% of fructose, 5-30% of sublimable substance, 0.5-3% of a surfactant, 4-20% of a disintegrating agent, 0.5-3.0% of a flow aid, 0.5-3.0% of a lubricant, 20.0-58% of a diluent, 0.2-2% of a corrigent, and 3-8% of a coating material. The invention further provides a preparation method of the compound sodium fructose diphosphate and fructose orally disintegrating tablets. The preparation method comprises the following steps: mixing the active ingredients, namely sodium fructose diphosphate and fructose, and pharmaceutical excipients, wherein the sublimable substance is added into the pharmaceutical excipients, tabletting the mixture, coating the obtained semi-finished product tablets, heating the semi-finished product tablets after coating, and drying, thus the sublimable substance sublimates, a plurality of holes are formed in the tablets, and finally, the tablets capable of rapidly disintegrating and with certain strength are obtained. The orally disintegrating tablets can rapidly disintegrate, so that good clinical effects can be obtained; the preparation method is easy and convenient to operate, is suitable for industrial production, and has a large application value.