The invention discloses a formula of health-care buccal tablets capable of refreshing, relieving fatigue and clearing heat from throat. The formula of the health-care buccal tablets is prepared from the following raw materials in parts by weight: 15 to 25 parts of honeysuckle flowers, 9 to 18 parts of dandelion, 16 to 22 parts of lemon, 4 to 9 parts of momordica grosvenori, 18 to 25 parts of coffee, 30 to 38 parts of green tea, 20 to 40 parts of areca-nut, 4 to 10 parts of liquorice roots, 6 to 12 parts of fructo-oligose, 6 to 12 parts of maltodextrin, 1 to 3 parts of magnesium stearate, 1 to3 parts of a talcum powder and 1 to 4 parts of soluble starch. The invention also discloses a preparation method of the formula of the health-care buccal tablets. The health-care buccal tablets are prepared by sequentially decocting and extracting the raw materials, concentrating into paste and preparing a dry paste fine powder, granules and tablets. The health-care buccal tablets capable of refreshing, relieving fatigue and clearing heat from throat, which is provided by the invention, can improve the immunity of a human body, enables people to feel excited, can eliminate fatigue after intensive labor, can relieve sore throat and can reduce throat discomfort.