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Acetaminophen, caffeine, chlorphenamine maleate, and vitamin C preparation and preparation method thereof

A preparation, the technology of paracetamol, applied in the field of medicine, can solve the problems of low bioavailability, poor water solubility, etc., achieve the effects of reducing irritation and side effects, preventing deterioration and degradation, and shortening the course of treatment

Active Publication Date: 2012-02-15
石药集团中诺药业(石家庄)有限公司
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AI Technical Summary

Problems solved by technology

[0006] The preparation is aimed at the poor water solubility of acetaminophen and the low bioavailability of oral administration of solid preparations. The preparation of acetaminophen-β-cyclodextrin inclusion compound is used to solve this problem, because the prescription contains four main drugs ingredients, in order to ensure the stability of each ingredient of the product, the above-mentioned problems associated with conventional methods in the preparation of fixed-dose combination drugs containing the above-mentioned ingredients can all be overcome by a bilayer tablet containing β-cyclodextrin The first layer of embedded acetaminophen, and the second layer containing chlorpheniramine maleate, caffeine, vitamin C, acetaminophen made into β-cyclodextrin inclusion complex significantly increased its Stability and dissolution rate, the double-layer tablets prepared in this way are not easy to split and have better quality

Method used

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  • Acetaminophen, caffeine, chlorphenamine maleate, and vitamin C preparation and preparation method thereof
  • Acetaminophen, caffeine, chlorphenamine maleate, and vitamin C preparation and preparation method thereof
  • Acetaminophen, caffeine, chlorphenamine maleate, and vitamin C preparation and preparation method thereof

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Embodiment Construction

[0060] The following examples are only used to illustrate the present invention, but not to limit the present invention.

[0061]

[0062] Note: The cellulose derivatives in the above table are hydroxypropyl methylcellulose, hypromellose or hypromellose.

[0063] Examples 1-7 are respectively a kind of aminophenol-kamin vitamin C preparation, which is a double-layer tablet structure, and the active ingredients include acetaminophen, caffeine, vitamin C, and chlorpheniramine maleate. The prescriptions of raw and auxiliary materials for making 1000 tablets of the above-mentioned medicine are shown in the table above, and their preparation methods are respectively carried out according to the following steps:

[0064] ①Preparation of the first layer of particles:

[0065] (1) Weigh acetaminophen, add absolute ethanol to dissolve it completely under stirring, and prepare solution A for later use;

[0066] (2) Add purified water into the mixing tank, heat to 57-63°C, stop heat...

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Abstract

The invention discloses an acetaminophen, caffeine, chlorphenamine maleate, vitamin C preparation and a preparation method thereof, wherein the preparation is double-layer tablets which are respectively an acetaminophen granular layer embedded by beta-cyclodextrin, and a caffeine, chlorphenamine maleate and vitamin C granular layer, which are moulded by a tablet press. The preparation uses the beta-cyclodextrin to embed the acetaminophen so as to remarkably improve the stability and dissolution rate of the acetaminophen and reduce the stimulation and toxic side effects of medicaments; the beta-cyclodextrin can further reduce the offensive odour of the medicaments; moreover, the invention adopts the synergistic effect of the acetaminophen and the vitamin C so as to shorten the treatment course for curing the cold and make the cold be not easy to relapse; and the double-layer tablet structure achieves the purposes of isolating the acetaminophen and the caffeine, the chlorphenamine maleate and the vitamin C and solves the problems of metamorphic degradation, poor stability, short period of efficacy and the like caused by the interaction of the medicaments. The preparation is not easy to split, and is excellent in quality. The method is used for preparing the acetaminophen caffeine chlorphenamine maleate vitamin C double-layer tablet, and the preparation is mainly used for treating disease such as cold.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to a cold medicine preparation, in particular to an acetaminophen-kamin vitamin C preparation and a preparation method thereof. Background technique [0002] Cold is a kind of common disease, has a strong impact on people's daily work and life. There are many kinds of medicines used to treat colds, among which medicines containing acetaminophen, chlorpheniramine maleate, caffeine and other components are common cold preparations, but due to the poor water solubility of acetaminophen, causing Oral administration of solid dosage forms has low bioavailability. [0003] Cyclodextrin can effectively increase the solubility and dissolution rate of some poorly water-soluble drugs in water, and it can also improve the stability and bioavailability of drugs; reduce the bad smell or bitter taste of drugs; reduce the irritation and side effects of drugs; As well as the effects of sustained r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61K31/4402A61K31/375A61K31/167A61K9/26A61P11/00A61P29/00A61P31/00
Inventor 王蓓马慧丽李冬梅董朝篷汪玉梅张丽娜
Owner 石药集团中诺药业(石家庄)有限公司
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