The invention discloses a wormwood polyether insole, which comprises, by weight, 5-20% of wormwood, 75-90% of polyether, 0.5-1% of a catalyst and 2-5% of water. According to the insole, the wormwood is combined with the polyether as a raw material, and the polyether forms small holes after foaming, so that a better ventilation effect can be achieved; meanwhile, the formation of the micropores alsohas good damping and sweat absorption and deodorization effects, and the softness and comfort of the insole are increased; and secondly, the specially added wormwood increases the antibacterial, bacteriostatic and health-care effects of the insole, increases the physiotherapy effect of the insole on feet of a human body, and promotes the health of the human body. In addition, the invention also discloses a preparation process of the wormwood polyether insole, which comprises the following steps of: mixing and foaming the required raw materials, then cutting and die-casting, and finally cutting the finished product or directly injecting the finished product into a mold for in-mold molding to obtain the required finished insole; the preparation process is simple in operation and low in manufacturing cost, and is suitable for large-scale popularization and application.