Cefadroxil tablet and preparation method thereof

A technology of cefadroxil tablets and cefadroxil, which is applied in the direction of pharmaceutical formulas, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., can solve the problem of poor disintegration effect, limited disintegration effect, and dissolution rate Instability and other problems, to achieve the effect of high dissolution rate, short disintegration time limit and good disintegration effect

Active Publication Date: 2015-07-29
HUNAN KELUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the disintegration effect of the disintegrating agent in the traditional preparation method is limited, and it is greatly affected by other factors such as the concentration of the binder, wet mixing time, and moisture after drying, and the control of the moisture and hardness of the intermediate product is slightly limited. If there is a difference, it will cause poor disintegration effect and unstable dissolution rate.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0044] The present invention also provides a kind of preparation method of the cefadroxil tablet described in above-mentioned technical scheme, comprises the following steps:

[0045] a) granulating cefadroxil, microcrystalline cellulose, sodium starch glycolate and starch after mixing to obtain cefadroxil granules;

[0046] b) compressing the cefadroxil granules, microcrystalline cellulose and lubricant into tablets after mixing to obtain cefadroxil tablets.

[0047] In the present invention, cefadroxil, microcrystalline cellulose, sodium starch glycolate and starch are mixed and granulated to obtain cefadroxil granules. In the present invention, the cefadroxil is the main component of the cefadroxil tablet provided by the invention; You can sell the goods. In the present invention, the particle size of the cefadroxil is preferably less than or equal to 100 mesh, more preferably less than or equal to 80 mesh.

[0048] In the present invention, the microcrystalline cellulos...

Embodiment 1

[0073] (1) First, add 75kg cefadroxil, 4.5kg microcrystalline cellulose and 1.5kg carboxymethyl starch sodium into the HZ-250B high-efficiency wet granulator, stir at a low speed of 6r / s for 600s, and then turn on Cutter, the speed of the cutter is 10r / s and high-speed stirring is carried out for 60s to obtain cefadroxil mixed powder.

[0074] Simultaneously, 21340g of water is added in the pulping pot, and then 660g of starch is added, steam is heated, and the pressure is 0.2MPa to obtain starch slurry.

[0075] Then, the above-mentioned starch slurry was evenly added into the cefadroxil mixed powder, stirred at a low speed for 60s at a rate of 6r / s, and then opened the cutter, and the cutter was stirred at a high speed of 10r / s for 270s to obtain the cefadroxil soft material .

[0076] Finally, the cefadroxil soft material is added to the YK-160B swinging granulator, granulated with a 20-mesh sieve, then dried by the MJ50-5 vacuum low-temperature solid dryer, and sized by t...

Embodiment 2

[0079] (1) First, add 75kg of cefadroxil, 3kg of microcrystalline cellulose and 1.2kg of carboxymethyl starch sodium into the HZ-250B high-efficiency wet granulator, stir at a low speed of 6r / s for 600s, and then start the cutting process. Knife, cutting knife speed is 10r / s and carries out high-speed stirring 60s, obtains cefadroxil mixed powder.

[0080] Simultaneously, 21340g of water is added in the pulping pot, and then 660g of starch is added, steam is heated, and the pressure is 0.2MPa to obtain starch slurry.

[0081] Then, the above-mentioned starch slurry was evenly added into the cefadroxil mixed powder, stirred at a low speed for 60s at a rate of 6r / s, and then opened the cutter, and the cutter was stirred at a high speed of 10r / s for 270s to obtain the cefadroxil soft material .

[0082] Finally, the cefadroxil soft material is added to the YK-160B swinging granulator, granulated with a 20-mesh sieve, then dried by the MJ50-5 vacuum low-temperature solid dryer, a...

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Abstract

The invention provides a cefadroxil tablet. The cefadroxil tablet is prepared by mixing and tabletting cefadroxil particles, micro-crystal cellulose and a lubricating agent. The cefadroxil particle comprises the following ingredients: 250 parts by weight of cefadroxil, 10 to 20 parts by weight of micro-crystal cellulose, 2 to 4 parts by weight of starch, and 4 to 6 parts by weight of carboxymethyl starch sodium. Compared with the prior art, the cefadroxil tablet adopts the carboxymethyl starch sodium as a disintegrating agent which is unique in swelling effect; moreover, the micro-crystal cellulose is respectively added in the granulating and tabletting process, so that the cefadroxil is more uniformly dispersed, a product tablet core has good disintegrating effect, the particles can be rapidly disintegrated, the dissolution rate of the product is high, and the disintegrating time is short. The experiment result shows that the dissolution rate of the cefadroxil tablet is 87 to 103 percent, and the disintegrating time is 4 to 6 minutes.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a cefadroxil tablet and a preparation method thereof. Background technique [0002] Cefadroxil, English name is Cefadroxil, molecular formula is C 16 h 17 N 3 o 5 S·H 2 O, the molecular weight is 381.41, the chemical structure formula is as follows: [0003] [0004] Cefadroxil is a bactericidal broad-spectrum cephalosporin antibiotic effective against infections with Gram-positive and Gram-negative bacteria. Oral cefadroxil preparations can be used to treat mild to moderately susceptible infections such as pharyngitis or streptococcal tonsillitis caused by the bacteria Streptococcus pyogenes, urinary tract infections, reproductive tract infections, and skin infections, which have good water solubility It has a certain degree of fat solubility, good oral absorption, and is not affected by food in the stomach. It is relatively slow in gastrointestinal absorption and uri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/545A61K47/36A61K47/38A61P31/04
Inventor 李全学廖孝曙逯佩荣刘志军江力军方永煌刘思川程志鹏万阳浴葛均友
Owner HUNAN KELUN PHARMA
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