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Micro-powder encapsulating and material mixing device for improving content uniformity of clonidine hydrochloride in zhenju antihypertensive tablets and material mixing method

A technology of clonidine hydrochloride and Zhenju Jiangya tablets, which is applied in the field of biomedicine, can solve problems such as poor process stability, secondary environmental pollution, and complex production processes, and achieve the goal of improving content uniformity, reducing workload, and reducing errors Effect

Active Publication Date: 2018-12-28
ZHONGXING PHARM CO LTD JIANGSU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The addition of clonidine hydrochloride in Zhenju Jiangya Tablets in the traditional process adopts the method of equal increase, solvent dissolution and mixing and prolonging the mixing time. Not only the production process is complicated, the operation is cumbersome, and it is easy to cause secondary environmental pollution. problem, and the process stability is relatively poor, and there is a problem that the content of clonidine hydrochloride in the prepared Zhenju Jiangya Tablets will be uneven due to human differences in operation

Method used

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  • Micro-powder encapsulating and material mixing device for improving content uniformity of clonidine hydrochloride in zhenju antihypertensive tablets and material mixing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Please refer to Figure 1-Figure 2 As shown, a micropowder encapsulation mixing device for improving the content uniformity of clonidine hydrochloride in Zhenju Jiangya Tablets, including a drug dosing unit 1 and a drug mixing unit 2 located directly below the drug adding unit 1;

[0032] The dosing unit 1 includes a dosing container 11 and a dosing pipeline 12; the dosing pipeline 12 extends from the bottom of the dosing container 11 to the inner top of the mixing unit 2; the end of the dosing pipeline 12 is provided with a dosing nozzle 13;

[0033] The drug mixing unit 2 includes a drug mixing container 21, a first stirring device 23 and a second stirring device 22 arranged vertically from top to bottom, and a PLC central control center 24 arranged on the side wall of the drug mixing container 21; The first stirring device 23 extends to the outer wall of the mixing container 21 and is connected with a first stirring motor 231; the second stirring device 22 extends t...

Embodiment 2

[0042] The micropowder encapsulation and mixing device is the same as in Example 1.

[0043] According to the prescription formula ratio of Zhenju Jiangya Tablets in the "International Drug Standards of the State Food and Drug Administration"; use the above-mentioned mixing method of a micropowder encapsulation mixing device that improves the content uniformity of clonidine hydrochloride in Zhenju Jiangya Tablets , including the following steps:

[0044] 1) get clonidine hydrochloride 0.03g and be dissolved in the ethanol solution of 30g 93%, prepare the clonidine hydrochloride solution that dissolves completely;

[0045] 2) Place the completely dissolved clonidine hydrochloride solution in the dosing container 11;

[0046] 3) Add the required amount of Zhenju Jiangya Tablets to the mixing container 21 to prepare raw materials other than clonidine hydrochloride: wild chrysanthemum flower cream powder: 100g; pearl layer powder: 100g; clonidine hydrochloride: 0.03g; Hydrochlor...

Embodiment 3

[0050] The micropowder encapsulation and mixing device is the same as in Example 1.

[0051] According to the prescription formula ratio of Zhenju Jiangya Tablets in the "International Drug Standards of the State Food and Drug Administration"; use the above-mentioned mixing method of a micropowder encapsulation mixing device that improves the content uniformity of clonidine hydrochloride in Zhenju Jiangya Tablets , including the following steps:

[0052] 1) get clonidine hydrochloride 0.03g and be dissolved in the ethanol solution of 30g 95%, prepare the clonidine hydrochloride solution that dissolves completely;

[0053] 2) Place the completely dissolved clonidine hydrochloride solution in the dosing container 11;

[0054] 3) Add the required amount of Zhenju Jiangya Tablets to the mixing container 21 to prepare raw materials other than clonidine hydrochloride: wild chrysanthemum flower cream powder: 100g; pearl layer powder: 100g; clonidine hydrochloride: 0.03g; Hydrochlor...

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Abstract

The invention discloses a micro-powder encapsulating and material mixing device for improving the content uniformity of clonidine hydrochloride in zhenju antihypertensive tablets and a material mixingmethod. The material mixing method comprises the following steps: firstly, a clonidine hydrochloride solution is prepared by dissolving clonidine hydrochlorid with an ethanol solution, and is uniformly sprayed to a medicine mixing container containing other auxiliary materials while rotating at high speed in a dosing nozzle, furthermore, a transverse cutting blade and a longitudinal cutting bladeopposite to the dosing nozzle in the rotation direction are arranged in the medicine mixing container, and the medicine mixing container synchronously rotates at the high speed reversely while the materials are mixed until the solution is completely sprayed, the ethanol solution is volatilized in the high-speed rotating container, and the clonidine hydrochloride and the other raw materials form amicro-powder encapsulating state to complete the micro-powder encapsulating and material mixing process; and the micro-powder encapsulating and material mixing device for improving the content uniformity of the clonidine hydrochloride in the zhenju antihypertensive tablets and the material mixing method disclosed by the invention effectively improve the mixing uniformity and the bonding firmnessdegree of the clonidine hydrochloride, enhance the content uniformity of the clonidine hydrochloride in finished product tablets of the zhenju antihypertensive tablets, lower errors in the proceduresof artificial compounding, material mixing and the like, reduce the workload and improve the work efficiency.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a micronized powder wrapping mixing device and a mixing method for improving the content uniformity of clonidine hydrochloride in Zhenju Jiangya Tablets. Background technique [0002] Zhenju Antihypertensive Tablets are composed of mother-of-pearl powder, wild chrysanthemum flower cream powder, clonidine hydrochloride, hydrochlorothiazide, and rutin. The component clonidine hydrochloride is a central sympathetic nerve inhibitor, which has a good antihypertensive effect and a certain lipid-lowering effect. Clonidine hydrochloride in Zhenju Jiangya Tablets can excite imidazoline receptors and reduce peripheral sympathetic tension; Stimulates central α2 receptors; agonizes peripheral sympathetic presynaptic membrane α2 receptors and reduces plasma renin and aldosterone levels. The content of clonidine hydrochloride is very important for Zhenju Jiangya Tablets. The amount of clonidine hyd...

Claims

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Application Information

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IPC IPC(8): B01F13/10A61K31/4168
CPCA61K31/4168A61K35/618A61K31/549A61K36/287A61P9/12B01F33/833B01F33/83611A61K2300/00
Inventor 武俊明
Owner ZHONGXING PHARM CO LTD JIANGSU
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