A new preparation for treating acute injury of soft tissue and its preparation method

A transdermal patch, ethanol extraction technology, applied in the directions of non-central analgesics, anti-inflammatory agents, drug combinations, etc., can solve the problems of unreachable drugs, low skin permeability, high therapeutic concentration, etc., and reduce side effects. , avoid intestinal inactivation, avoid the effect of first pass effect

Active Publication Date: 2018-06-01
WUXI JIYU SHANHE PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The skin is a physiological barrier that restricts substances from outside the body to enter the body. Most drugs pass through this barrier very slowly, and generally take a few hours to take effect after administration, and most drugs cannot reach high therapeutic concentrations.
Especially for water-soluble drugs, the skin penetration rate is very low
However, the development of transdermal patches with specific targeting and specific action time takes advantage of this limitation

Method used

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  • A new preparation for treating acute injury of soft tissue and its preparation method
  • A new preparation for treating acute injury of soft tissue and its preparation method
  • A new preparation for treating acute injury of soft tissue and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Extraction of traditional Chinese medicine:

[0048] Put the rest of the eight medicinal materials except Fritillaria zhe zhe into the multifunctional extraction tank. Add 5 times the amount of 95% ethanol of the medicinal materials, open the jacket steam valve to heat, extract under reflux at 70-75 °C for 2 hours, and release the alcohol extract; then add 4 times the amount of 95% ethanol, and extract under reflux at 70-75 °C for 2 hours , the two alcohol extracts were combined. Pass the alcohol extract through a 120-mesh sieve, and place a single-effect concentration tank (-0.06Mpa pressure) to recover ethanol to a thick paste with a relative density of 1.35-1.39 (55°C).

[0049] Extraction of Fritillaria:

[0050] Extract 2 times with 6 times the amount of 95% ethanol, 1h each time (whole grain extraction).

[0051] Preparation of patches:

[0052] The extract, 5% azone and 5 times hydrophilic medical pressure-sensitive adhesive were mixed according to the prescrip...

Embodiment 2

[0054] Extraction of traditional Chinese medicine:

[0055] Put the rest of the eight medicinal materials except Fritillaria zhe zhe into the multifunctional extraction tank. Add 5 times the amount of 95% ethanol of the medicinal materials, open the jacket steam valve to heat, extract under reflux at 70-75 °C for 2 hours, and release the alcohol extract; then add 4 times the amount of 95% ethanol, and extract under reflux at 70-75 °C for 2 hours , the two alcohol extracts were combined. Pass the alcohol extract through a 120-mesh sieve, and place a single-effect concentration tank (-0.06Mpa pressure) to recover ethanol to a thick paste with a relative density of 1.35-1.39 (55°C).

[0056] Extraction of Fritillaria:

[0057] Extract 2 times with 6 times the amount of 95% ethanol, 1h each time (whole grain extraction).

[0058] Preparation of patches:

[0059] The extract, 2.5% azone and 2.5 times hydrophilic medical pressure-sensitive adhesive were mixed according to the pr...

Embodiment 3

[0061] Extraction of traditional Chinese medicine:

[0062] Put the rest of the eight medicinal materials except Fritillaria zhe zhe into the multifunctional extraction tank. Add 5 times the amount of 95% ethanol of the medicinal materials, open the jacket steam valve to heat, extract under reflux at 70-75 °C for 2 hours, and release the alcohol extract; then add 4 times the amount of 95% ethanol, and extract under reflux at 70-75 °C for 2 hours , the two alcohol extracts were combined. Pass the alcohol extract through a 120-mesh sieve, and place a single-effect concentration tank (-0.06Mpa pressure) to recover ethanol to a thick paste with a relative density of 1.35-1.39 (55°C).

[0063] Extraction of Fritillaria:

[0064] Extract 2 times with 6 times the amount of 95% ethanol, 1h each time (whole grain extraction).

[0065] Preparation of patches:

[0066] The extract, 2.5% azone and 1.375 times hydrophilic medical pressure-sensitive adhesive were mixed according to the ...

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Abstract

The invention relates to a new preparation for treating acute injury of soft tissue and a preparation method thereof. The invention changes Sprain Gui capsule into a traditional Chinese medicine transdermal absorption patch. The preparation method of Sprained Gui transdermal patch is characterized in that the active drugs are extracted with ethanol from 9 medicinal materials of Angelica sinensis, Fangfeng, Citrus aurantium, Anemarrhena, Aracea (manufactured), Trichosanthes mellifera, Angelica dahurica, Safflower, and Fritillaria japonicus. Appropriate amount of penetration enhancer and appropriate amount of pressure-sensitive adhesive base, coated on non-woven fabric, cut into appropriate size. The feature of the invention is to reduce the administration times, avoid the liver first-pass effect and gastrointestinal inactivation that may occur in oral administration, and reduce the side effects of gastrointestinal administration.

Description

Technical field: [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a new dosage form for regulating qi, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain and being used for acute injury of soft tissues such as chest, flank, back and limbs, and its prescription composition and preparation method. technical background: [0002] Transdermal therapeutic systems (TTS) refers to a class of preparations that are administered through skin application, and the drug is absorbed from the skin into the systemic blood circulation and reaches an effective blood drug concentration to achieve disease treatment or prevention. [0003] Compared with common dosage forms, such as oral tablets, capsules or injections, transdermal patches have the following characteristics: (1) It can avoid the first-pass effect of the liver and gastrointestinal inactivation that may occur in oral administration; (7) It ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61P29/00
Inventor 毛菊红
Owner WUXI JIYU SHANHE PHARM CO LTD
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