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Antibiotic composition, preparation method thereof and purpose thereof

A technology of antibiotics and compositions, which is applied in the field of antibiotic compositions, can solve the problems such as the decline in curative effect of third-generation cephalosporins, and achieve the effects of reducing MIC value, enhancing antibacterial effect, and improving antibacterial effect

Active Publication Date: 2012-05-23
HAIKOU PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In recent years, due to the increase of drug-resistant strains and the emergence of extended-spectrum β-lactamases, the efficacy of third-generation cephalosporins has declined

Method used

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  • Antibiotic composition, preparation method thereof and purpose thereof
  • Antibiotic composition, preparation method thereof and purpose thereof
  • Antibiotic composition, preparation method thereof and purpose thereof

Examples

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Effect test

Embodiment 1

[0032] Under sterile conditions, 10 kg of cephradine (calculated as cephradine) and 10 kg of tazobactam sodium (calculated as tazobactam) were placed in a double-cone mixer, mixed for 20 to 30 minutes, and the rotating speed was 60 rpm. Minutes, be subpackaged into 10000 powder injections with a fully automatic dispensing machine, each containing cephradine 1.0 grams (calculated in cephradine).

Embodiment 2

[0034] Under sterile conditions, 20 kg of cephradine (calculated as cephradine) and 10 kg of tazobactam sodium (calculated as tazobactam) were placed in a double-cone mixer, mixed for 20 to 30 minutes, and the rotating speed was 60 rpm. Minutes, be subpackaged into 20000 powder injections with a full-automatic packing machine, each containing cephradine 1.0 gram (calculated as cephradine).

Embodiment 3

[0036]Under sterile conditions, 30 kg of cephradine (calculated as cephradine) and 10 kg of tazobactam sodium (calculated as tazobactam) were placed in a double-cone mixer, mixed for 20 to 30 minutes, and the rotating speed was 60 rpm. Minutes, be subpackaged into 30000 powder injections with a full-automatic dispensing machine, each containing cephradine 1.0 gram (in terms of cephradine).

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Abstract

The invention provides an antibiotic composition, a preparation method thereof and purpose thereof. The antibiotic composition provided in the invention comprises a component A and a component B, wherein the component A is cefradine or a salt thereof, and preferably cefradine; the component B is tazobactam or a salt thereof, and preferably tazobactam; and the weight ratio of the component A to the component B is 1-16:1. The invention also provides the preparation method and the purpose of the composition. The antibiotic composition provided in the invention, which has a substantial synergistic antibiotic effect and allows the antibiotic activity of cefradine to be enhanced and the generation of the bacterial drug resistance to be simultaneously inhibited, can be prepared into powder for injection.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an antibiotic composition comprising cephradine and tazobactam, a preparation method and application thereof. Background technique [0002] Cephradine is the first generation of cephalosporin antibiotics, its chemical name is: (6R,7R)-7[(R)-2-amino-2-(1,4-cyclohexenyl)acetamido]-3- Methyl-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid. Molecular formula is C 16 h 19 N 3 o 4 S, the molecular weight is 349.40, the structural formula is as follows: [0003] [0004] The effect of cephradine on Gram-positive bacteria and Gram-negative bacteria is similar to that of cephalexin. Some strains of Gram-positive cocci such as Streptococcus viridans have good antibacterial effects. Anaerobic Gram-positive bacteria are more sensitive to cephradine, and Bacteroides fragilis is resistant to cephradine. Methicillin-resistant Staphylococcus and Enterococcus were resist...

Claims

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Application Information

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IPC IPC(8): A61K31/545A61K31/431A61K9/14A61P31/04
CPCY02A50/30
Inventor 沙莹曾祎华刘悉承
Owner HAIKOU PHARMA FACTORY
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