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Ceftriaxone sodium and tazobactam sodium composition

A technology of tazobactam sodium and ceftriaxone sodium, applied in the direction of active ingredients of heterocyclic compounds, antibacterial drugs, etc., can solve problems such as poor stability, increase toxic and side effects, increase pharmacological activity, and improve antibacterial effects

Inactive Publication Date: 2006-02-15
李志林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has the characteristics of broad-spectrum, long-acting, high-efficiency, and low toxicity. It has antibacterial effects on Gram bacteria and Pseudomonas aeruginosa resistant to multiple antibacterial drugs, but has poor stability against ESBLs produced by Gram-negative bacteria. certain drug resistance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Implementation 1 One of the preparation examples of ceftriaxone sodium and tazobactam sodium composition

[0016] Get 2 parts (weight) of ceftriaxone sodium and tazobactam sodium composition and 1 part (weight) of tazobactam sodium, place in the V-type mixer in 100 class clean room, mix 5 minutes, pass 30-mesh sieve; put the mixed drug solution in a mixer for 5 minutes, and then pass through a 30-mesh sieve; repeat this process 3 times; put the mixed drug powder in a sterile tank and seal it tightly. Then check the content of the intermediate according to the quality standard for clinical use, and carry out aseptic packaging after passing the test. In order to reduce the influence of residual oxygen on the drug content, a second nitrogen filling process is adopted during the aseptic subpackaging process, so that the oxygen content in the liquid medicine bottle is controlled at about 1% (one-time nitrogen filling, the residual oxygen content is 5% or so) to ensure the s...

Embodiment 2

[0017] Example 2 The second preparation example of the composition of ceftriaxone sodium and tazobactam sodium

[0018] Get 4 parts (weight) of ceftriaxone sodium and tazobactam sodium composition and 1 part (weight) of tazobactam sodium, place in the V-type mixer in 100 class clean room, mix 5 minutes, pass 30-mesh sieve; put the mixed drug solution in a mixer for 5 minutes, and then pass through a 30-mesh sieve; repeat this process 3 times; put the mixed drug powder in a sterile tank and seal it tightly. Then check the content of the intermediate according to the quality standard for clinical use, and carry out aseptic packaging after passing the test. In order to reduce the influence of residual oxygen on the drug content, a second nitrogen filling process is adopted during the aseptic subpackaging process, so that the oxygen content in the liquid medicine bottle is controlled at about 1% (one-time nitrogen filling, the residual oxygen content is 5% or so) to ensure the st...

Embodiment 3

[0019] Example 3 Preparation Example 3 of the Composition of Ceftriaxone Sodium and Tazobactam Sodium

[0020] Get 5 parts (weight) of ceftriaxone sodium and tazobactam sodium composition and 1 part (weight) of tazobactam sodium, place in the V-type mixer in 100 class clean room, mix 5 minutes, pass 30-mesh sieve; put the mixed drug solution in a mixer for 5 minutes, and then pass through a 30-mesh sieve; repeat this process 3 times; put the mixed drug powder in a sterile tank and seal it tightly. Then check the content of the intermediate according to the quality standard for clinical use, and carry out aseptic packaging after passing the test. In order to reduce the influence of residual oxygen on the drug content, a second nitrogen filling process is adopted during the aseptic subpackaging process, so that the oxygen content in the liquid medicine bottle is controlled at about 1% (one-time nitrogen filling, the residual oxygen content is 5% or so) to ensure the stability o...

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PUM

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Abstract

The invention relates to a composition of ceftriaxone sodium and tazobactam sodium, which comprises active constituents of ceftriaxone sodium and tazobactam sodium by the weight ratio of 1-10:1, preferably 2-8:1, optimally 4:1. The compound preparation can appreciably reinforce the antibiotic action to Gram-negative bacteria.

Description

technical field [0001] The invention relates to a pharmaceutical composition with broad-spectrum antibacterial effect, in particular to a composition of ceftriaxone sodium and tazobactam sodium. Background technique [0002] Ceftriaxone sodium has another name called ceftriaxone, and its trade name is roseazine. This drug is the first long-acting third-generation cephalosporin successfully developed in 1978. This product can inhibit the synthesis of mucopeptides in the process of bacterial cell wall synthesis, affect the cross-linking of peptide chains, and make cells unable to form complete cell walls and sterilize. It has the characteristics of broad-spectrum, long-acting, high-efficiency, and low toxicity. It has antibacterial effects on Gram bacteria and Pseudomonas aeruginosa resistant to multiple antibacterial drugs, but has poor stability against ESBLs produced by Gram-negative bacteria. Certain drug resistance. [0003] Bacterial drug resistance is a natural select...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61P31/04A61K31/43
Inventor 李志林黄瑶蔡鹤其
Owner 李志林
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