Preparation method for ginkgolide C

Abstract

The invention discloses a preparation method for ginkgolide C. The method is characterized by comprising the step of carrying out column chromatographic separation on a crude extract of ginkgo biloba by using a macroporous reverse-phase adsorption resin, wherein, parameters of the macroporous reverse-phase adsorption resin are that a particle size is 50 to 100 mu m, bore diameter is 90 to 110 A and a resin framework is polystyrene-divinylbenzene. The preparation method provided in the invention enables high product yield to be obtained and product purity to be high.

Description

technical field

[0001] The invention relates to a preparation method of ginkgolide C. Background technique

[0002] Ginkgo biloba L. is a plant of the genus Ginkgo in the Ginkgo family. It appeared about 200 million years ago. It was nearly extinct during the Ice Age and only survived in my country. It was called a "living fossil" by Darwin. With the in-depth research on Ginkgo biloba, it has been proved that the active ingredients of Ginkgo biloba are mainly flavonoids and lactones. Among them, the lactone compounds are: ginkgolide A (BN52020), ginkgolide B (BN52021), ginkgolide C (BN52022), ginkgolide M (BN52023), ginkgolide J (BN52024) and bilobalide . Studies have shown that ginkgolides are strong platelet-activating factor (platelet-activating factor, PAF) receptor antagonists. Their unique pharmacological effects and therapeutic value have aroused great interest in the pharmaceutical industry worldwide.

[0003] With the gradual clarification of effective medicinal...