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Activity enhancer for oxidized protein hydrolase

A technology of protein hydrolysis and enzyme activity, applied in the direction of non-central analgesics, anti-inflammatory agents, anti-toxic agents, etc., can solve the problem of enzyme activity reduction, and achieve the effects of promoting decomposition, treating and preventing diseases, and excellent productivity

Inactive Publication Date: 2012-05-23
ARKRAY INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

) and other proteolytic enzymes are decomposed and removed, but the activity of these enzymes decreases with age (Non-Patent Document 2)

Method used

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  • Activity enhancer for oxidized protein hydrolase
  • Activity enhancer for oxidized protein hydrolase
  • Activity enhancer for oxidized protein hydrolase

Examples

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Embodiment

[0058] Next, examples of the present invention will be described. However, the present invention is not limited to the following examples.

[0059] In this example, the effect of plant extracts and mixed extracts on OPH activity was evaluated. In addition, in this example, as the above-mentioned plants, flower bulbs of Roman chamomile, aerial parts of Houttuynia cordata, fruits of Western hawthorn, and leaves of grapes were used. A commercial item AARE (manufactured by TAKARA BIO Co., Ltd.) was used as OPH.

[0060] Preparation of plant extracts

[0061] 100 g of the dried material of each of the above plants was immersed in 10 L of purified water at 80° C. for about 5 hours to obtain an extract of each plant. Each extraction extract was filtered to remove the residue, and about 10 kg of the filtrate was recovered respectively. Each filtrate was dried and the solvent was removed to obtain a powder of each plant extract. In addition, "AG Harbu MIX" (trade name, manufactu...

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Abstract

Disclosed is an activity enhancer for oxidized protein hydrolase. The activity enhancer for oxidized protein hydrolase is characterized by comprising an extract of at least one plant selected from the group consisting of plants belonging to Compositae Anthemis (Chamaemelum), Saururaceae Houttuynia, Rosaceae Crataegus and Vitaceae Vitis. It is preferable that the activity enhancer for oxidized protein hydrolase comprises an extract of a plant belonging to Compositae Anthemis (Chamaemelum), an extract of a plant belonging to Saururaceae Houttuynia, an extract of a plant belonging to Rosaceae Crataegus and an extract of a plant belonging to Vitaceae Vitis. It is also preferable that the plant belonging to Compositae Anthemis (Chamaemelum) is Anthemis nobilis L., the plant belonging to Saururaceae Houttuynia is Houttuynia cordata Thunberg, the plant belonging to Rosaceae Crataegus is Crataegus oxyacantha L. and the plant belonging to Vitaceae Vitis is Vitis vinifera L.

Description

technical field [0001] The present invention relates to an activity enhancer of oxidative proteolytic enzyme (decomposing enzyme). Background technique [0002] Oxidation reactions and glycosylation reactions in vivo are known to have adverse effects on cells and tissues. In particular, the production and accumulation of proteins subjected to oxidation or glycosylation (i.e., oxidized or glycosylated proteins) can cause diseases such as diabetic complications, Alzheimer's disease, cataracts, arteriosclerosis, and tissues such as skin Aging and functional reduction of the (Non-Patent Document 1). Therefore, the above-mentioned oxidized protein and the above-mentioned glycosylated protein are also called damage proteins. [0003] Usually, these harmful proteins are decomposed and removed by proteolytic enzymes such as proteasome and oxidized protein hydrolase (Oxidized Protein Hydrolase, hereinafter referred to as "OPH"), but the activity of these enzymes decreases with age ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/18A61P1/16A61P3/10A61P7/00A61P9/00A61P9/10A61P13/12A61P17/00A61P19/02A61P19/08A61P19/10A61P25/00A61P25/28A61P27/02A61P27/12A61P29/00A61P43/00
CPCA61K36/734A61K36/87A61K36/28A61K36/78A61P1/16A61P13/12A61P17/00A61P19/02A61P19/08A61P19/10A61P25/00A61P25/28A61P27/02A61P27/12A61P29/00A61P39/06A61P43/00A61P7/00A61P9/00A61P9/10A61P3/10A61K2300/00A61K36/73
Inventor 八木雅之高桥朋子
Owner ARKRAY INC
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