Small animal living body multi-mode molecule imaging system and imaging method

Abstract

The invention discloses a small animal living body multi-mode molecule imaging system and an imaging method. The imaging system comprises a Cerenkov luminous imaging device, a nuclide imaging device and a MicroCT (micro computed tomography) device which respectively acquire Cerenkov optical signals, nuclide signals and X-ray signals of body surfaces of small animals. The X-ray signals are reconstructed by the aid of cone-beam back-projection algorithm, and information of an anatomical structure of a small animal is obtained; the Cerenkov optical signals are reconstructed on the basis of a mixed light transmission theory, and three-dimensional distribution information of a Cerenkov target is obtained; and the obtained Cerenkov target information and the obtained anatomical structure information are fused and displayed, so that multi-mode imaging is completed. A single-mark probe/multi-mode imaging mode which integrates high specificity of nuclide imaging, high sensitivity of optical imaging and high resolution of X-ray imaging is realized, so that multi-mode image information of small animal living bodies is more complete, comprehensive and accurate.

Description

technical field [0001] The invention belongs to the technical field of image processing, and relates to nuclide imaging and Cherenkov luminescence imaging based on radionuclide, MicroCT imaging, especially a multi-modal molecular imaging device and an optical imaging three-dimensional imaging method, which can be used for in vivo molecules of small animals imaging. Background technique [0002] Molecular imaging technology has achieved rapid development in the past decade, and has been widely used in small animal experiments and pre-clinical experiments such as tumor detection and drug development. At present, the commonly used imaging technologies mainly include nuclide imaging, MRI, and optical imaging. These modalities have different characteristics, and have their own advantages and disadvantages in terms of system specificity, sensitivity, and equipment cost. Nuclide imaging, such as PET and SPECT imaging, has high sensitivity and is not limited by the detection depth,...

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Problems solved by technology

Higher-order approximations to the radiative transfer equation enable accurate imaging of small animal objects with both high-scattering and low-scattering tissue, see: J.Zhong, J.Tian, ​​X.Yang, C.Qin, Whole-Body Cerenkov Luminescence Tomography with the Finite Element SP3 Method, Annals of Biomedical Engineering, 39: 1728-1735 (2011). This method can guarantee a certain solution accuracy, but it is very difficult to solve high-order approximation equations. For inhomogeneous light with com

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