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Sugar-free granule for treating chronic fatigue syndrome and preparation method and detecting method thereof

A technology for chronic fatigue and detection methods, which is applied to medical preparations containing active ingredients, antidote, and drug combinations, etc., can solve the problem of large viscosity of extracts, stability of drug quality and accuracy of clinical efficacy. Grain difficulty, etc.

Active Publication Date: 2012-06-13
ZHEJIANG DADE PHARMACEUTICAL GROUP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Xiaomeiling granule is a pure traditional Chinese medicine prescription for chronic fatigue syndrome, but the traditional wet granulation process of this granule has the disadvantages of high viscosity of extract, large amount of extract, difficult granulation, and high sugar content. There are limitations in the use of drugs for people and sugar-free patients
In addition, there is no perfect quality inspection standard for Xiaoliiling Granules, and the stability of its drug quality and the accuracy of its clinical efficacy need to be improved urgently

Method used

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  • Sugar-free granule for treating chronic fatigue syndrome and preparation method and detecting method thereof
  • Sugar-free granule for treating chronic fatigue syndrome and preparation method and detecting method thereof
  • Sugar-free granule for treating chronic fatigue syndrome and preparation method and detecting method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0144] Example 1: Preparation of sugar-free granules for treating chronic fatigue syndrome:

[0145] Take ginseng 75g, Ophiopogon 250g, Schisandra 150g, Angelica 150g, Astragalus 250g, Longan meat 200g, Cinnamon 50g, Ganoderma 150g, Spatholobus 150g, Poria cocos 125g, Hawthorn 250g, Salvia 150g, Date seed 150g, Ejiao 100g and Stevia 5g, dextrin 767g; Ejiao crushed into fine powder, set aside; the remaining ginseng, Ophiopogon japonicus, Schisandra, Angelica, Astragalus, Longan meat, cinnamon, Ganoderma lucidum, Coriander, Poria, Hawthorn, Salvia, Ziziphus 13 herbs Add 8 times the amount of water and 6 times the amount of water to decoct twice for 2 hours each time, combine the decoction, filter, and concentrate the filtrate into a thick paste (relative density 1.25-1.30, 60℃), add 5.5-6.0 times ethanol Measure, stir, stand, divide the supernatant, add 2 times the amount of 85% ethanol to the residue, stir, stand, combine the two supernatants, filter, and recover the ethanol from ...

Embodiment 2

[0146] Embodiment 2 of the present invention: The detection method of sugar-free granules for the treatment of chronic fatigue syndrome includes the following items:

[0147] Properties: The preparation is light brown to tan granules; it has a slight gas, sweet and slightly bitter taste.

[0148] Identification: (1) Take 12g of Ophiopogon japonicus granules, grind them, add 40ml ethanol, heat and reflux for 1 hour, let cool, filter, evaporate the filtrate, add 20ml water to the residue to dissolve, add water-saturated n-butanol and shake Extract 3 times, 20ml each time, combine the n-butanol layer, wash twice with 0.1% sodium hydroxide solution, 30ml each time, divide the n-butanol solution, evaporate to dryness, add 2ml ethanol to the residue to dissolve, as the test product Solution; take another 1g of Ophiopogon japonicus reference medicinal material, add 20ml of ethanol, sonicate for 40 minutes, filter, evaporate the filtrate to dryness, add 1ml of ethanol to the residue to dis...

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Abstract

The invention discloses a sugar-free granule for treating chronic fatigue syndrome and a preparation method and a detecting method thereof, wherein the sugar-free granule is prepared by the following ingredients in parts by weight: 75 parts of ginseng, 250 parts of dwarf lilyturf root, 150 parts of fructus schizandrae, 150 parts of angelica, 250 parts of astragalus root, 200 parts of arillus longan, 50 parts of cinnamon, 150 parts of lucid ganoderma, 150 parts of leatherleaf milletia, 125 parts of tuckahoe, 250 parts of hawthorn, 150 parts of radix salviae miltiorrhizae, 150 parts of jujube kernels, 100 parts of donkey-hide gelatin, 5 parts of steviosin and 767 parts of dextrin. The sugar-free preparation of the invention has the advantages of fast dissolution speed, high bioavailability and good stability so as to solve the drug use limit problem of diabetics and old patients, thereby expanding the adaptable crowds; besides, the detecting method of the invention has the advantages of high precision, good repeatability and accurate measurement result, thereby effectively guaranteeing the clinical treatment effect of the preparation.

Description

Technical field [0001] The invention relates to a sugar-free granule for treating chronic fatigue syndrome, a preparation method and a detection method thereof, and belongs to the technical field of traditional Chinese medicine. Background technique [0002] With the development of economy, the accelerating pace of life, and the intensifying social competition, people have to be stressed and busy, and their bodies and minds are in a state of full or overloaded operation for a long time. They cannot get proper relaxation and rest, and eventually become sick from overwork. , Unknowingly became a chronic fatigue syndrome. Chronic fatigue syndrome is a syndrome mainly characterized by chronic or repeated episodes of extreme fatigue, low-grade fever, sore throat, muscle pain, arthralgia, headache, and neuropsychiatric symptoms. According to epidemiological surveys, 14% of adult men and 29% of women in the population have obvious symptoms of fatigue, and more than 40% of the patients ...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K9/16G01N30/36G01N30/90A61P39/00A61K35/36
Inventor 王国保王建国陈法贵徐丽君
Owner ZHEJIANG DADE PHARMACEUTICAL GROUP CO LTD
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