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Medicinal composition for treating diabetes mellitus

A composition and technology for diabetes are applied in the field of pharmaceutical compositions for type II diabetes and their preparation, pharmaceutical compositions for the treatment of diabetes and the fields of their preparation, which can solve problems such as impaired insulin secretion, achieve less recurrence, reduce economic burden, The effect of a short course of treatment

Inactive Publication Date: 2013-06-19
高芹凤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, β-cell dysfunction results in impaired insulin secretion that is progressively worse

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A pharmaceutical composition for treating type 2 diabetes, which is prepared from the following raw materials in proportion by weight:

[0026] Ophiopogon japonicus 20, Scutellaria baicalensis 18, Yam 18, Angelica 16, Anemarrhena 15, Japonica rice 12, Licorice 12, Astragalus 10, Atractylodes macrocephala 9, Paeoniae Alba 8, Black plum 7, Pueraria 6, Rehmannia glutinosa 6, Schisandra 4, Ginseng 4.

[0027] The preparation method of the above-mentioned pharmaceutical composition comprises the following steps: taking the above-mentioned raw materials in parts by weight for later use; adding 3 times the amount of water to decoct for 2 hours, collecting the filtrate by filtration, and concentrating the filtrate into an extract with a density of 1.2 g / ml; After drying, pulverize into 80-mesh medicinal powder, pack into capsules, and sterilize to obtain capsule preparations.

[0028] Dosage form and usage: The dosage form of this prescription is capsule dosage form, three time...

Embodiment 2

[0030] zoology experiment

[0031] Experimental animals: 40 SD rats, half male and half female, weighing 160-180 g, provided by the Animal Center of Linyi People's Hospital. After the rats were adapted to feeding in the animal room for 5 days, 8 rats were randomly selected as the normal control group and fed with ordinary maintenance feed. High-sugar and high-fat feed formula: rat basic feed 68%, sucrose 10%, egg yolk powder 9%, lard 8%, cholesterol 1%, bile salt 0.2%.

Embodiment approach

[0032] Implementation method: the remaining 32 were fed with high-sugar and high-fat diet for 4 weeks. After 4 weeks, the rats were fasted for 24 hours, and streptozotocin (STZ) was injected intravenously at 20 mg / Kg, once every two days. Choose 24 successful rats of modeling, be divided into 3 groups at random, every group of 8, i.e. model group (do not use any medicine), the embodiment of the present invention 1 medicine group 10mg / Kg, control medicine group: use metformin hydrochloride ( 10mg / kg), the way of administration is oral, and it is taken half an hour before meals every day. Tested after 10 days of continuous use.

[0033] Statistical analysis: The data are represented by x ± s, and SPSS17.0 statistical software is used for data analysis. The comparison between multiple groups is by analysis of variance, and the comparison between two groups is by t test. P<0.05 is statistically significant.

[0034] Treatment effect: The biochemical indicators of fasting plasma...

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PUM

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Abstract

The invention relates to a medicinal composition for treating type II diabetes mellitus. The medicinal composition is prepared from the following raw materials in parts by weight: 18-22 parts of dwarf lilyturf root, 16-20 parts of baikal skullcap root, 16-20 parts of Chinese yam, 14-18 parts of Chinese angelica, 14-17 parts of common anemarrhena, 10-14 parts of polished round-grained rice, 10-14 parts of liquoric root, 8-12 parts of astragalus, 9-11 parts of large-head atractylodes rhizome, 7-9 parts of white paeony root, 6-8 parts of dark plum fruit, 5-7 parts of kudzuvine root, 5-7 parts ofprepared rehmannia, 3-5 parts of Chinese magnoliavine fruit and 3-5 parts of ginseng. The medicinal composition has the advantages of short treatment course, high total effective rate, prevention of relapse after curing, simple process, reduction in production cost and lowering of the economic burden of a patient.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a pharmaceutical composition for treating diabetes and a preparation method thereof, in particular to a type II diabetes pharmaceutical composition and a preparation method thereof. Background technique [0002] Diabetes (diabetes) is a sugar, protein, A series of metabolic disorder syndromes such as fat, water and electrolytes are clinically characterized by hyperglycemia. In typical cases, polyuria, polydipsia, polyphagia, weight loss and other manifestations may appear, namely "three excesses and one deficiency" symptoms. Diabetes ( Once the blood sugar is not well controlled, it will cause complications, leading to failure and lesions of the kidneys, eyes, feet and other parts, which cannot be cured. Clinical observation Insulin resistance is common in type Ⅱ diabetes, up to about 90%. Type 2 diabetes, also known as non-insulin-dependent diabetes mellitus (N...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61P3/10
Inventor 高芹凤王春霞
Owner 高芹凤