Medicine preparation for treating schizophrenia and preparation method thereof
A pharmaceutical preparation and schizophrenia technology, which is applied in the direction of drug combination, pharmaceutical formula, medical raw materials derived from birds, etc., can solve the problems of lack of enthusiasm and initiative, indifference to the future, and shortage, so as to reduce economic burden and reduce production High cost and total effective efficiency
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Embodiment 1
[0035] A pharmaceutical preparation for schizophrenia, characterized in that it is prepared from the following raw materials:
[0036] Quetiapine 15kg, starch 22kg, carboxymethyl starch sodium 2.5kg, traditional Chinese medicine ingredients 10kg, dextrin 22kg, microcrystalline cellulose 1.5kg, 85% (volume ratio) ethanol 28kg, magnesium stearate 0.8kg.
[0037] Take the above raw materials, granulate according to the conventional method, and prepare 1,000,000 tablets.
[0038] The Chinese medicine composition is prepared from raw materials of the following weight:
[0039] 35 parts of white peony, 35 parts of rhubarb, 35 parts of Ophiopogon japonicus, 33 parts of Moutan bark, 30 parts of polygala,
[0040] 30 parts of cinnabar, 30 parts of Codonopsis, 30 parts of Polygonum multiflorum, 28 parts of Cortex Phellodendri, 28 parts of Dilong,
[0041] Fushen 27 parts, ebony plum 27 parts, lily 25 parts, salvia miltiorrhiza 25 parts, turmeric 25 parts,
[0042] 25 parts of coptis,...
Embodiment 2
[0054] Acute toxicity test: 40 mice, half male and half female, weighing 30-40 g, were used for acute toxicity test. The mice were randomly divided into two groups, i.e. a control group and an administration group, 20 in each group, fasted for 12 hours before the experiment, and the administration group was given the pharmaceutical preparation prepared in Example 1 of the present invention dissolved in water for intragastric administration ( Oral gavage with a single dosage of 30g crude drug / kg), the control group was given the same amount of normal saline, administered twice a day, with an interval of 6 hours between administrations, continuous observation for two weeks after administration, and the toxicity of the mice was recorded reactions and deaths. The results of the experiment showed that compared with the control group, there was no significant difference in the mice after administration. After 14 days of continuous observation in the experiment, the general condition...
Embodiment 3
[0057] The clinical data selected 98 clinical patients, including 41 males and 57 females, the youngest was 19 years old, the oldest was 63 years old, the shortest course of disease was three months, and the longest was 10 years. Among them, 77 cases suffered from schizophrenia and 21 cases suffered from mania. Divide into two groups at random, every group of 49 people, embodiment 1 group and control group, two groups of patients' gender, age, course of disease, through statistical processing, have no significant difference (P>0.05), have comparability.
[0058] Diagnostic criteria: Acute stage: mental excitement, sleepless nights, headache and mania, glaring eyes, red face, red ears, mania often does not avoid relatives and estrangements, frenzy, swearing at people and destroying things, going to the house, singing loudly, shouting after a long period of illness Positive symptoms are slightly slow, stupefied, incoherent, talkative, hyperactive, panic, restlessness, insomnia, ...
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