Method for measuring dimethyl fumarate in product by gas chromatography-mass spectrometry

Abstract

The invention discloses a method for measuring dimethyl fumarate in a product by gas chromatography-mass spectrometry. The method comprises the following steps of: pre-treating a dimethyl fumarate product to be detected by using an ultrasonic extraction method; setting experiment conditions of a gas chromatography-mass spectrometer; enabling a sample solution to enter a chromatographic column through a sample inlet, and carrying out temperature programming on the temperature of the chromatographic column to separate the components of the sample solution by the chromatographic column; and enabling the components of the sample solution separated by the chromatographic column to enter a mass spectrometric detection part through a port of the gas chromatography-mass spectrometer. The method for measuring the dimethyl fumarate in the product by the gas chromatography-mass spectrometry has low detection limit, good detection effect, low consumption of an analysis solvent and low detection cost.

Description

technical field [0001] The invention relates to a method for detecting dimethyl fumarate in a product, in particular to a method for detecting dimethyl fumarate in a product by gas chromatography-mass spectrometry. Background technique [0002] Dimethyl Fumarate (Dimethyl Fumarate, DMF for short) is a white powdery crystal with a slight ester fragrance. It can effectively inhibit and kill more than 30 kinds of molds, yeasts and bacteria. Therefore, it is widely used in industry, agriculture, food and other industries. For example, DMF is used for mildew prevention of building materials, wood products and plastic products, and it is also used in food and catering industry, medicinal materials, tobacco, textiles, film, leather and its products, Anti-mold, anti-moth and disinfection of paper, paint, dye, adhesive, etc. [0003] However, studies have shown that DMF can enter the human body through the digestive tract, respiratory tract and skin, causing skin allergies, irritati...

AI Technical Summary

Problems solved by technology

[0005] The present invention proposes a method for the determination of dimethyl fumarate in products by gas chromatography-mass spectrometry, which has strong separation and analysis ability, fast and accurate qualitative identification ability, and low detection cost, so as to solve the problem that currently only Can quantitatively determine the content of each component in the product, the sample pretreatment process is cumbersome, and the use of liquid chromatography to analyze the solvent consumption is large, the detection cost is high and other technical problems