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Air-space low-interference phase microscope based on liquid crystal tunable filter

A tuned filter and phase microscope technology, applied in the field of low-coherence phase microscopy in space, can solve the problems of limited application range, inability to detect sample nanostructure changes, lack of quantitative information, etc., achieve high spatial domain refractive index fluctuation sensitivity, and achieve high High-precision imaging and simple optical path structure

Inactive Publication Date: 2013-08-21
CHONGQING UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0002] Since the imaging of samples by traditional optical microscopes is based on the absorption or fluorescence effects of samples, the resolution is low (<500nm), and changes in the nanostructure of samples cannot be detected.
Optical-based phase-contrast microscopy and differential interference contrast microscopy are capable of probing subtle cellular nanostructural changes, but lack of quantitative information limits their applications
In recent years, quantitative phase microscopy can obtain phase, amplitude and other system parameters related to the characteristics of cell nanostructures by using the interference effect, and provides quantitative information. Although this type of microscope can detect cell nanostructures, its speed, sensitivity and accuracy, as well as for The special requirements of the sample limit its promotion to clinical application

Method used

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  • Air-space low-interference phase microscope based on liquid crystal tunable filter

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Embodiment Construction

[0015] The present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments.

[0016] Such as figure 1 As shown, a spatial low-coherence phase microscope based on a liquid crystal tunable filter includes a white light source 1, a beam splitter 8, a first objective lens 9, a stage 10, a first mirror 7, a tube mirror 15, and a liquid crystal tunable The filter 16 and the CCD image sensor 17, in order to adjust and collimate the light of the white light source, a collimating light path is also arranged between the white light source 1 and the beam splitter 8, and the collimating light is routed through the condenser 2, the first lens 3. The first diaphragm 4, the second lens 5 and the second diaphragm 6 are arranged in sequence.

[0017] The white light source 1 adopts a xenon lamp light source, which emits white light with high intensity and low coherence. The white light emitted by the white light source 1 is p...

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Abstract

The invention discloses an air-space low-interference phase microscope based on a liquid crystal tunable filter. The air-space low-interference phase microscope comprises an object stage, a first object lens, a first reflecting mirror, a ductoscopy and a CCD (Charge Coupled Device) image sensor and is characterized by further comprising a white light source, a spectroscope and a liquid crystal tunable filter, wherein the spectroscope is used for receiving white light signals which are focused into an observed sample through the first object lens, reflected scattered signals of the observed sample are projected into the ductoscopy through the first object lens and the first reflecting mirror, the liquid crystal tunable filter is arranged between the ductoscopy and the CCD image sensor, andthe liquid crystal tunable filter is used for projecting microscope images of different wavelengths onto the CCD image sensor. The air-space low-interference phase microscope has the obvious effects that: a light path structure is simple, the control is convenient, a system has high air-space refractive index and fluctuation sensitivity and can be used for processing a clinical sample slide directly so as to realize high-precision imaging for a cell nano-structure, and the full-field rapid measurement is realized by utilizing electro-optic liquid crystal tunning.

Description

technical field [0001] The invention relates to a phase microscope, in particular to a liquid crystal tunable filter-based spatial low-coherence phase microscope, which belongs to the optical imaging technology. Background technique [0002] Since the imaging of samples by traditional optical microscopes is based on the absorption or fluorescence effects of samples, the resolution is low (<500nm), and changes in the nanostructure of samples cannot be detected. Optical-based phase-contrast microscopy and differential interference contrast microscopy are capable of probing subtle cellular nanostructural changes, but the lack of quantitative information limits their applications. In recent years, quantitative phase microscopy can obtain phase, amplitude and other system parameters related to the characteristics of cell nanostructures by using the interference effect, and provides quantitative information. Although this type of microscope can detect cell nanostructures, its s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G02B21/00G01N21/45G02F1/03G02B1/11
Inventor 王品李勇明于彦涛夏宇任超梅林
Owner CHONGQING UNIV
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