Long-path optical fiber-microfluidic chip sensor for detecting absorbance and refraction index

Abstract

The invention discloses a long-path optical fiber-microfluidic chip sensor for detecting absorbance and refraction index, which comprises a microfluidic chip made of a transparent material. A detection passage, an incident optical fiber passage and an emergent optical fiber passage are arranged in the microfluidic chip. The detection passage is provided with a sample inlet, a sample outlet, a light incidence port and a light emergence port. The detection passage is arranged between the incident optical fiber passage and the emergent optical fiber passage. The detection passage, the incident optical fiber passage and the emergent optical fiber passage are mutually isolated. Emergent light from the incident optical fiber passage is absorbed by a sample in the detection passage, is reflected by the inner wall surface of a side wall and then shoots into the emergent optical fiber passage. The incident optical fiber passage and the emergent optical fiber passage are respectively matched with optical fibers which are arranged in the incident optical fiber passage and the emergent optical fiber passage. The end surface of the emergent ends of the optical fibers in the incident optical fiber passage and the end surface of the light emergence port of the incident optical fiber passage are on the same level. The end surface of the emergent ends of the optical fibers in the emergent optical fiber passage and the end surface of the light incidence port of the emergent optical fiber passage are at the same level. The long-path optical fiber-microfluidic chip sensor for detecting absorbance and refraction index can realize high-sensitivity biochemical sensing at low sample consumption.

Description

technical field [0001] The invention relates to a sensor based on an optical fiber and a microfluidic chip, in particular to a high-sensitivity, trace liquid biochemical sensor for detection of absorbance and refraction index. Background technique [0002] Microfluidic chips are one of the hotspots of scientific research today, and have broad application prospects in life sciences, chemistry, optics and other fields. The channel scale of microfluidic chips is usually on the order of tens to hundreds of microns. The channel has a network structure, and the precise control of the microliter to picoliter liquid flow in the channel can be realized through external or integrated pump valves. Microfluidic chips increase the requirements for detectors while greatly reducing sample consumption. The currently used microfluidic chip optical detector usually relies on a complex optical system, which severely limits its application field. Moreover, due to the small channel size of the ...

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Problems solved by technology

Although this solution achieves high-sensitivity absorbance detection, it is difficult to process curved mirrors and requires high-precision lithography equipment, and the sensor can only be used for absorbance measurement

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