2results about How to "Avoid dead volume" patented technology

This invention relates to the field of biosensing technology, providing a self-driven sorting device with a near-field direct-write gradient grid and its fabrication method. The invention aims to solve the problems of existing microfluidic sorting devices, such as reliance on external power, susceptibility to stacking and clogging, and severe human background interference. The device constructs a spatially heterogeneous geometric topological grid in situ on a porous substrate using a near-field direct-write process, forming a three-level gradient path consisting of a primary coarse filtration zone, a secondary sorting zone, and a tertiary retention zone. This invention utilizes substrate capillary forces to drive sample flow and achieves physical guidance and precise retention of human cells through a deterministic lateral displacement mechanism. While significantly increasing sample processing throughput, it drastically reduces the proportion of human reads in sequencing, providing a convenient and efficient technical platform for automated preprocessing of complex biological samples and high-sensitivity clinical detection.

The invention relates to the technical field of amorphous alloy material preparation, in particular to a double-roller quenching device for amorphous alloy strip preparation, which comprises two symmetrically arranged roller bodies and a driving adjusting assembly for driving the two roller bodies to reversely rotate, and the two roller bodies are symmetrically arranged from top to bottom; a cooling assembly is arranged on the roller bodies, the cooling assembly comprises a water inlet, a water outlet, a first cooling cavity, a second cooling cavity and a flow guide plate, the water inlet is formed in one end of each roller body, the water outlet is formed in the other end of each roller body, the two ends of each roller body are rotationally connected with connectors respectively, and connecting pipes are arranged on the connectors on the two sides. The double-cavity cooling roller has the beneficial effects that through the composite cooling structure design of the double cooling cavities and the spiral guide plates, the technical problems that a traditional single-cavity cooling roller is uneven in heat exchange and low in cooling efficiency are effectively solved.