6results about How to "Avoid dead volume" patented technology

This invention relates to the field of biosensing technology, providing a self-driven sorting device with a near-field direct-write gradient grid and its fabrication method. The invention aims to solve the problems of existing microfluidic sorting devices, such as reliance on external power, susceptibility to stacking and clogging, and severe human background interference. The device constructs a spatially heterogeneous geometric topological grid in situ on a porous substrate using a near-field direct-write process, forming a three-level gradient path consisting of a primary coarse filtration zone, a secondary sorting zone, and a tertiary retention zone. This invention utilizes substrate capillary forces to drive sample flow and achieves physical guidance and precise retention of human cells through a deterministic lateral displacement mechanism. While significantly increasing sample processing throughput, it drastically reduces the proportion of human reads in sequencing, providing a convenient and efficient technical platform for automated preprocessing of complex biological samples and high-sensitivity clinical detection.

The utility model provides a trace oxygen sensor. The trace oxygen sensor comprises a sensor body, a sensor circuit board and a sensor base body, the sensor base body is provided with a cylindrical cavity, the sensor body is arranged in the cavity, the electric signal input end of the sensor circuit board is connected to the electric signal output end of the sensor body, the sensor base body is provided with a cover body, and the cover body is matched with the sensor base body to seal the sensor body. The sensor circuit board is arranged between the cover body and the sensor body; the sensor base body is provided with an air inlet and an air outlet, an annular air groove is formed in the inner side wall of the sensor base body, the air inlet is communicated with the annular air groove, the air outlet is communicated with the bottom of a cavity of the sensor base body, the overshoot phenomenon can be avoided, and the sensitivity and precision of the trace oxygen sensor are improved.

The utility model discloses a filtering membrane bag which comprises a liquid inlet unit and a filtering unit which are alternately stacked, the liquid inlet unit comprises a liquid inlet screen, and the filtering unit comprises a filtrate screen and filtering membranes stacked on the two sides of the filtrate screen; each of the liquid inlet screen and the filtrate screen comprises a screen body as well as a liquid inlet hole and a filtrate hole which are formed in the screen body, and the filtrate hole formed in the liquid inlet screen and the liquid inlet hole formed in the filtrate screen form a packaging hole; a packaging hole is formed in the net body, the net body is further provided with a glue sealing groove located in the peripheral side of the packaging hole, the glue sealing groove is filled with packaging glue, a first glue sealing part is formed, the filtering membrane bag further comprises a second glue sealing part formed by the packaging glue permeating into the net body, and the first glue sealing part and the second glue sealing part are connected to seal the periphery of the packaging hole. And the projection of the filter membrane on the net body at least partially covers the glue sealing groove. According to the filtering membrane bag disclosed by the utility model, the packaging performance of the packaging hole can be improved, so that the sealing reliability of the filtering membrane bag is improved.

The utility model discloses a micro-fluidic chip and an in vitro detection device, and relates to the field of containers or utensils for experiments, a drainage groove of the micro-fluidic chip extends along a tangent line of a reaction cavity and is arranged on the side wall of the bottom of the reaction cavity, and a first side wall positioned below the tangent line is provided with an arc section. The drainage groove not only tangentially guides liquid flow into the bottom of the reaction cavity to be in contact with a freeze-drying ball so as to prevent the liquid flow from directly flushing and blocking an exhaust flow channel, but also forms a gap with an increased width in the side wall of the reaction cavity, thereby being beneficial to destroying the interface energy at the front end of the liquid flow and enabling a liquid sample to enter the reaction cavity more easily. In addition, the side wall of the top of the reaction cavity is also provided with an intercepting groove which is used as a capillary valve to inhibit the liquid sample from entering the exhaust flow channel before the gas enters the exhaust flow channel. The micro-fluidic chip is provided with a liquid separation cavity, and secondary preferential distribution is carried out on liquid flow. The forked flow channels annularly surround the reaction cavities, the structure is compact, and the reaction cavities connected with the different forked flow channels are partitioned.

The utility model discloses a liquid separation runner for microfluidics and a micro-fluidic chip, and relates to the field of containers or utensils for experiments. In the liquid separation flow channel, the liquid separation cavity is provided with a second branched flow channel and a first branched flow channel. Due to the fact that the width of the first bifurcated flow channel is smaller than that of the second bifurcated flow channel, the capillary force of the first bifurcated flow channel is larger, and the inlet of the first bifurcated flow channel is lower than that of the second bifurcated flow channel, a liquid sample in the liquid separation cavity can enter the first bifurcated flow channel more easily, and it is preferentially guaranteed that the first bifurcated flow channel is filled with the liquid sample; and the liquid flow is subjected to secondary priority distribution, so that a priority selection function is realized. In addition, a first table top, a transition face and a second table top which are sequentially connected are arranged between the first forked flow channel and the second forked flow channel at one end, communicated with the second forked flow channel, of the liquid separation cavity. Therefore, the liquid separation cavity forms a drainage space above the inlet of the first bifurcated flow channel, so that a liquid sample can enter the first bifurcated flow channel more easily.

The invention relates to the technical field of amorphous alloy material preparation, in particular to a double-roller quenching device for amorphous alloy strip preparation, which comprises two symmetrically arranged roller bodies and a driving adjusting assembly for driving the two roller bodies to reversely rotate, and the two roller bodies are symmetrically arranged from top to bottom; a cooling assembly is arranged on the roller bodies, the cooling assembly comprises a water inlet, a water outlet, a first cooling cavity, a second cooling cavity and a flow guide plate, the water inlet is formed in one end of each roller body, the water outlet is formed in the other end of each roller body, the two ends of each roller body are rotationally connected with connectors respectively, and connecting pipes are arranged on the connectors on the two sides. The double-cavity cooling roller has the beneficial effects that through the composite cooling structure design of the double cooling cavities and the spiral guide plates, the technical problems that a traditional single-cavity cooling roller is uneven in heat exchange and low in cooling efficiency are effectively solved.