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Microfluidic device

A microfluidic device and microfluidic technology, applied in the field of chromatographic analysis, can solve the problems of embolism expansion, pollution, and inefficient separation, and achieve the effect of avoiding clogging and avoiding dead volume.

Active Publication Date: 2018-03-27
PHARMAFLUIDICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to their position in the specific configuration of prior art devices, these valves and connections often also have the disadvantage that a portion of the sample is trapped in the dead volume of the valve or is introduced by the valve.
Not only does this have a negative impact on the amount of sample available, but it can also cause contamination of the various separated phases, causing the separation to occur less efficiently
Furthermore, in conventional configurations, these dead volumes can lead to significant plug enlargement during the injection step, leading to a negative impact on analytical separations

Method used

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Embodiment Construction

[0053] The present invention will be described with reference to certain drawings and with respect to specific embodiments, however, the invention will not be limited thereto but only by the claims.

[0054] Reference throughout this specification to "one embodiment" or "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment of the present invention. Thus, the appearances of the expression "in one embodiment" or "in an embodiment" in various places throughout the specification need not necessarily all be known to refer to the same embodiment, but may do. Furthermore, the particular features, structures or characteristics may be combined in any suitable manner as would be apparent to a person skilled in the art based on this disclosure in one or more embodiments.

[0055] Similarly, it is to be understood that in the description of exemplary embodiments of the invention, var...

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Abstract

A microfluidic device (100) for separating a phase in a specimen has been described. This is based on a microfluidic trapping area (110), channels (120,130) connected to it and integrated inputs (I1,I2) and outputs (U1,U2) connected onto the channels (120,130). An additional integrated input (I3) is provided which allows the flow in the device to be controlled and which may prevent leaking of thespecimen and the phase.

Description

technical field [0001] The present invention relates to the field of separation of liquid phases. More specifically, the present invention relates to microfluidic systems having a specific configuration for separating liquid phases, for example for chromatography. Background technique [0002] Chemical reactor systems utilizing fluid propagation have many applications, including production of chemical components, nanoparticle synthesis, component separation and / or extraction, and more. [0003] In fluid-propagation-based separation techniques, differences in the affinity of the various substances in the mobile phase and in the stationary phase and / or differences in partition coefficients for partitioning of components are often exploited. Since each species has its own "binding force" to the stationary phase, they will move faster or slower in the mobile phase, and thus, certain species can be separated from others. In principle, this can be applied to any composition, wit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/08
CPCG01N1/405G01N30/08G01N30/6004G01N30/6095G01N2030/085G01N2030/383G01N2030/385G01N30/06G01N2030/027
Inventor J·欧普德贝克P·雅克布斯W·德马尔斯彻
Owner PHARMAFLUIDICS NV
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