Automatic multi-dimensional gas-phase chromatographic system and use with non-valve pressure switching

A multi-dimensional gas chromatography, fully automatic technology, applied in the application field of mixture analysis, can solve the problems affecting the analysis results, easy to leak, dead volume, etc., to reduce costs, overcome debugging difficulties, and improve the effect of analysis

Active Publication Date: 2007-02-21
SHANGHAI TOBACCO GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this system has the following disadvantages: (1) an external valve box is required, resulting in an increase in cost; (2) the active cutting valve is prone to air leakage during use, and the failure rate is high, resulting in an increase in cost; (3) there is a dead valve volume, it is necessary to increase the special supplementary gas path, so that the cost will increase accordingly; (4) The contact surface between the sample on the cutting valve and stainless steel and graphite is relatively large, which may be active and affect the analysis results

Method used

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  • Automatic multi-dimensional gas-phase chromatographic system and use with non-valve pressure switching
  • Automatic multi-dimensional gas-phase chromatographic system and use with non-valve pressure switching
  • Automatic multi-dimensional gas-phase chromatographic system and use with non-valve pressure switching

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Embodiment 1

[0044] The structural features and beneficial effects achieved by the present invention will be further described below in conjunction with the accompanying drawings and embodiments. Example 1: Multidimensional Chromatography / Mass Spectrometry Analysis of Flue-cured Tobacco Essential Oil Components

[0045] 1. Analysis sample: flue-cured tobacco essential oil, the sample preparation is briefly described as follows: take 50.00g of tobacco powder in a 1000ml flask, add 700ml of water and a few zeolites; take 100ml of dichloromethane in a 250ml flask, and distill and extract for 5 hours at the same time. The aroma components were distilled and extracted into dichloromethane, 30ml of 15% tartaric acid was added to extract the nicotine, dried over anhydrous sodium sulfate, and concentrated to 1.0ml through a Synger fractionation head at 60°C.

[0046] 2. Chromatographic conditions for GC-FID pre-run:

[0047] Pre-column: DB-5, 30m×0.25mm id×0.25um df; analytical column: DB-WAX, 30...

Embodiment 2

[0053] Example 2: Multidimensional Chromatography / Mass Spectrometry Analysis of Particulate Matter Components in Cigarette Smoke

[0054] 1. Analytical samples: cigarette smoke particulate matter, smoke particulate matter of 40 cigarettes, the treatment conditions are the same as tobacco essential oil.

[0055] 2. Chromatographic conditions for GC-FID pre-run: the same as flue-cured tobacco essential oil.

[0056] 3. Chromatographic conditions for heart-cutting analysis: the same as flue-cured tobacco essential oil.

[0057] 4. Analysis results

[0058] Figure 6 to Figure 8 are the relevant chromatograms of the GC-FID pre-run and the 3rd cut, where Figure 6 is the chromatogram of the pre-column-FID pre-run, Figure 7 Total ion chromatograms of the cut fractions on the analytical column-MS for 8-10 minutes, Figure 8 Monitor chromatograms for GC-FID during cut analysis. Cigarette smoke is one of the most complex samples in nature, and it is difficult to obtain satisfact...

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Abstract

An automatic multidimensional gas phase chromatography system is featured as switching mixture sample from precolumn to analysing column by controlling pressure difference between axiliary pressures based on pressure balance principle to have overcome defect of valve leakage and block in normal system. A method utilizing the system to analyse mixture is also disclosed.

Description

technical field [0001] The invention relates to a fully automatic multidimensional gas chromatographic system, in particular to a fully automatic multidimensional gas chromatographic system without valve pressure switching and its application in mixture analysis. Background technique [0002] Generally, in the gas chromatographic analysis of complex mixture samples, it is often necessary to use a multidimensional gas chromatograph formed by connecting two or more chromatographic columns in series. Generally, multidimensional gas chromatography has at least one pre-column and one analytical column. The sample to be tested flows through the pre-column after entering from the injection port, and then changes the flow direction of the sample through the gas circuit switching, from the pre-column to the cold trap for cooling, and then enters the analytical column for further analysis. There are three main ways to switch the gas circuit: (1) based on the principle of valveless pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/88G01N30/46G01N30/54
Inventor 施超
Owner SHANGHAI TOBACCO GRP CO LTD
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