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Traditional Chinese medicine extract for haemostasis and preparation method thereof

A technology of extract and traditional Chinese medicine, which is applied in the field of stem bark extract and preparation of Ash tree of Oleaceae, can solve the problems of unstable quality, large toxic and side effects, large dosage, etc., and achieve low raw material cost, high toxicity Less side effects and less dosage

Active Publication Date: 2012-08-15
NANJING AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Based on the above reasons, the purpose of the present invention is to develop a kind of wax tree extract with hemostatic effect, which overcomes the disadvantages of large toxic and side effects of western medicine and large dosage of traditional Chinese medicine compound, low purity, unstable quality and poor curative effect. , is a single traditional Chinese medicine extract with significant curative effect as an ideal drug for the treatment of hemostasis

Method used

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  • Traditional Chinese medicine extract for haemostasis and preparation method thereof
  • Traditional Chinese medicine extract for haemostasis and preparation method thereof
  • Traditional Chinese medicine extract for haemostasis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The influence of embodiment 1 Chinese medicine extract on mouse coagulation time and bleeding time

[0022] Mouse tail docking bleeding time (BT) and capillary coagulation time (CT) experiments are widely used in the activity screening of hemostatic and procoagulant drugs, and the method is intuitive, simple and easy to implement. Guided by the basic theory of hemostasis and coagulation, this experiment mainly uses these two methods to evaluate the hemostatic effect of traditional Chinese medicine extracts.

[0023] 1 Experimental materials

[0024] 1.1 Experimental animals: Kunming mice, weighing 18-20 g, provided by Qinglongshan Animal Breeding Farm, Jiangning District, Nanjing.

[0025] 1.2 Positive control drug: Yunnan Baiyao, Yunnan Baiyao Group Co., Ltd., batch number 20090605.

[0026] 1.3 Test reagents: ethanol, petroleum ether: Sinopharm Chemical Reagent Co., Ltd., analytically pure.

[0027] Distilled water, normal saline.

[0028] 1.4 Preparation of tradi...

Embodiment 2

[0049]Example 2 Chinese medicine extracts experiment on rabbit liver hemostasis

[0050] 1 Experimental materials

[0051] 11 Experimental animals: healthy rabbits, half male and half male, 1.8-2.0 kg, provided by Qinglongshan Animal Breeding Farm, Jiangning District, Nanjing.

[0052] 1.2 Positive control drug: Yunnan Baiyao, Yunnan Baiyao Group Co., Ltd., batch number 20090605.

[0053] 1.3 Test reagents: Same as above.

[0054] 1.4 Ulatan: Wuchang Yuancheng Technology Development Co., Ltd., batch number 080412.

[0055] 1.5 Preparation of traditional Chinese medicine extract 3

[0056] 1.5.1 Drying and pulverization: dry the stem bark of the wax tree in an oven at 40°C, pulverize it with a traditional Chinese medicine pulverizer and pass it through an 80-mesh sieve to obtain a powder.

[0057] 1.5.2 Extraction: Take 2 kg of powder, add petroleum ether in an amount 12 times the weight of the medicinal material powder, soak for 3 hours, reflux extraction at 60°C for 3 hou...

Embodiment 3

[0064] Embodiment 3 Chinese medicine extract is to dog femoral artery hemostasis experiment

[0065] 1 Experimental materials

[0066] 1.1 Experimental animals: dogs, provided by Qinglongshan Animal Breeding Farm, Jiangning District, Nanjing.

[0067] 1.2 Positive control drug: Yunnan Baiyao, Yunnan Baiyao Group Co., Ltd., batch number 20090605.

[0068] 1.3 Test reagents: Same as above.

[0069] 1.4 Ulatan: Same as above.

[0070] 1.5 Preparation of traditional Chinese medicine extract 4

[0071] 1.5.1 Drying and pulverization: Dry the stem bark of the wax tree in an oven at 50°C, pulverize it with a traditional Chinese medicine pulverizer and pass it through a 60-mesh sieve to obtain a powder.

[0072] 1.5.2 Extraction: take 2 kg of powder, add petroleum ether in an amount 8 times the weight of the medicinal material powder, soak for 2 hours, reflux extraction at 60°C for 3 hours, filter; add petroleum ether in an amount 6 times the weight of the powder to the filter res...

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Abstract

The invention discloses a traditional Chinese medicine extract for haemostasis and a preparation method thereof, and particularly a fraxinus platypoda oliver bark extract and a preparation method thereof. The extract of the invention is obtained by extracting and purifying fraxinus platypoda oliver barks by water or petroleum ether. The extract overcomes the disadvantages of great toxic and side effect for current western medicines and large dosage and low purity for traditional Chinese medicine compounds, has significant haemostasis effect, and also has the characteristics of few administration amount, high purity, and less toxic and side effect. The extract is an ideal medicament for haemostasis, and is widely applicable to various internal and external haemorrhage, surgical haemostasis, and the like.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a hemostatic traditional Chinese medicine extract and a preparation method thereof, in particular to an extract of the stem bark of the plant of the genus Ash in the family Oleaceae and a preparation method thereof. Background technique [0002] According to data, nearly 10 million patients with hemorrhagic disease are treated clinically in my country every year, mainly in surgical departments and some internal medicine departments, and most of them are clinically critical, urgent and severe. Excessive bleeding can lead to shock, which can be life-threatening. At the same time, bleeding is accompanied by pain and inflammation. If the bleeding cannot be stopped in time, it will accumulate in the body and cause other diseases. Therefore, hemostatic drugs are irreplaceable and necessary products in clinical practice, and have the characteristics of strong clinical complia...

Claims

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Application Information

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IPC IPC(8): A61K36/63A61P7/04A61K135/00
Inventor 沈克姑江善祥
Owner NANJING AGRICULTURAL UNIVERSITY
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