Traditional Chinese medicine extract for haemostasis and preparation method thereof

A technology of extract and traditional Chinese medicine, which is applied in the field of stem bark extract and preparation of Ash tree of Oleaceae, can solve the problems of unstable quality, large toxic and side effects, large dosage, etc., and achieve low raw material cost, high toxicity Less side effects and less dosage

Active Publication Date: 2012-08-15
NANJING AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Based on the above reasons, the purpose of the present invention is to develop a kind of wax tree extract with hemostatic effect, which overcomes the disadvantages of large toxic and side effects of western medicine and large do

Method used

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  • Traditional Chinese medicine extract for haemostasis and preparation method thereof
  • Traditional Chinese medicine extract for haemostasis and preparation method thereof
  • Traditional Chinese medicine extract for haemostasis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0021] Example 1 Effect of Chinese medicine extract on blood clotting time and bleeding time in mice

[0022] Mouse tail bleeding time (BT) and capillary clotting time (CT) experiments are widely used in the screening of hemostatic and procoagulant drugs. The method is intuitive, simple and easy to implement. In this experiment, guided by the basic theory of hemostasis and coagulation, these two methods are mainly used to evaluate the hemostatic effect of traditional Chinese medicine extracts.

[0023] 1 Experimental materials

[0024] 1.1 Experimental animals: Kunming mice, weighing 18-20g, provided by Qinglongshan Animal Breeding Farm in Jiangning District, Nanjing.

[0025] 1.2 Positive control drug: Yunnan Baiyao, Yunnan Baiyao Group Co., Ltd., batch number 20090605.

[0026] 1.3 Test reagents: ethanol, petroleum ether: Sinopharm Chemical Reagent Co., Ltd., analytical pure.

[0027] Distilled water, physiological saline.

[0028] 1.4 Preparation of Chinese medicine extract 1

[0029] ...

Example Embodiment

[0049] Example 2 Experiment of hemostatic effect of traditional Chinese medicine extract on rabbit liver

[0050] 1 Experimental materials

[0051] 11 Experimental animals: Healthy rabbits, half male and half, 1.8-2.0kg, provided by Qinglongshan Animal Breeding Farm in Jiangning District, Nanjing.

[0052] 1.2 Positive control drug: Yunnan Baiyao, Yunnan Baiyao Group Co., Ltd., batch number 20090605.

[0053] 1.3 Test reagent: Same as above.

[0054] 1.4 Ulatan: Wuchang Yuancheng Technology Development Co., Ltd., batch number 080412.

[0055] 1.5 Preparation of Chinese medicine extract 3

[0056] 1.5.1 Drying and crushing: dry the bark of elephant wax tree in a 40 ℃ drying oven, crush it with a Chinese medicine crusher, and pass it through an 80-mesh sieve to obtain powder.

[0057] 1.5.2 Extraction: Take 2 kg of powder, add 12 times the weight of the medicinal powder in petroleum ether, soak for 3 hours, reflux for 3 hours at 60℃, and filter; add petroleum ether 6 times the weight of the ...

Example Embodiment

[0064] Example 3 Experiment of Chinese medicine extract on dog femoral artery hemostasis

[0065] 1 Experimental materials

[0066] 1.1 Experimental animals: dogs, provided by Qinglongshan Animal Breeding Farm in Jiangning District, Nanjing.

[0067] 1.2 Positive control drug: Yunnan Baiyao, Yunnan Baiyao Group Co., Ltd., batch number 20090605.

[0068] 1.3 Test reagent: Same as above.

[0069] 1.4 Ulatan: Same as above.

[0070] 1.5 Preparation of Chinese medicine extract 4

[0071] 1.5.1 Drying and crushing: The bark of the elephant wax tree is dried in a drying oven at 50°C, crushed with a Chinese medicine crusher and passed through a 60-mesh sieve to obtain a powder.

[0072] 1.5.2 Extraction: Take 2 kg of powder, add petroleum ether 8 times the weight of the medicinal powder, soak for 2 hours, reflux for 3 hours at 60°C, and filter; add petroleum ether 6 times the weight of the powder to the filter residue, and extract 2 Hours, filter. Combine the 2 filtrates.

[0073] 1.5.3 Concentr...

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Abstract

The invention discloses a traditional Chinese medicine extract for haemostasis and a preparation method thereof, and particularly a fraxinus platypoda oliver bark extract and a preparation method thereof. The extract of the invention is obtained by extracting and purifying fraxinus platypoda oliver barks by water or petroleum ether. The extract overcomes the disadvantages of great toxic and side effect for current western medicines and large dosage and low purity for traditional Chinese medicine compounds, has significant haemostasis effect, and also has the characteristics of few administration amount, high purity, and less toxic and side effect. The extract is an ideal medicament for haemostasis, and is widely applicable to various internal and external haemorrhage, surgical haemostasis, and the like.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a hemostatic traditional Chinese medicine extract and a preparation method thereof, in particular to an extract of the stem bark of the plant of the genus Ash in the family Oleaceae and a preparation method thereof. Background technique [0002] According to data, nearly 10 million patients with hemorrhagic disease are treated clinically in my country every year, mainly in surgical departments and some internal medicine departments, and most of them are clinically critical, urgent and severe. Excessive bleeding can lead to shock, which can be life-threatening. At the same time, bleeding is accompanied by pain and inflammation. If the bleeding cannot be stopped in time, it will accumulate in the body and cause other diseases. Therefore, hemostatic drugs are irreplaceable and necessary products in clinical practice, and have the characteristics of strong clinical complia...

Claims

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Application Information

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IPC IPC(8): A61K36/63A61P7/04A61K135/00
Inventor 沈克姑江善祥
Owner NANJING AGRICULTURAL UNIVERSITY
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