Sugar-free type Chaihuang granules and preparing method thereof

A sugar-free and granule technology, which is applied in anti-inflammatory agents, pharmaceutical formulas, non-central analgesics, etc., can solve the problems of unwell patients and restrictions on clinical application, and achieve easy operation, reduced dosage, and increased production Effect

Inactive Publication Date: 2012-08-22
HENAN LINGYOU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation contains a large amount of sucrose, which is not suitable for patients with diabetes, hypertension, obesity, etc., which greatly restricts its clinical application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Prescription: Bupleurum 2500g Scutellaria baicalensis extract 180g

[0025] Preparation method: decoct the above two flavors, Bupleurum bupleurum with water twice, add 10 times the amount of water each time, 2 hours each time, combine the decoction, filter, concentrate the filtrate to a clear paste with a relative density of 1.10-1.20, stir Add ethanol until the alcohol content is 60%, let it stand for more than 12 hours, filter, recover ethanol from the filtrate, concentrate to an appropriate amount; take the extract of Scutellaria baicalensis, add appropriate amount of water to stir, add 20% sodium hydroxide solution to adjust the pH value to extract Scutellaria baicalensis The substance is completely dissolved, filtered, vacuum-dried and mixed with the above-mentioned Bupleurum extract, added aspartame 60g, dextrin 650g, mixed, made into granules, dried, made into 1000g, and obtained. 2 grams per bag.

Embodiment 2

[0027] Prescription: Bupleurum 2500g Scutellaria baicalensis extract 180g

[0028] Preparation method: decoct the above two flavors, Bupleurum bupleurum with water twice, add 10 times the amount of water each time, 2 hours each time, combine the decoction, filter, concentrate the filtrate to a clear paste with a relative density of 1.10-1.20, stir Add ethanol until the alcohol content is 60%, let it stand for more than 12 hours, filter, recover ethanol from the filtrate, concentrate to an appropriate amount; take the extract of Scutellaria baicalensis, add appropriate amount of water to stir, add 20% sodium hydroxide solution to adjust the pH value to extract Scutellaria baicalensis The mixture is completely dissolved, filtered, vacuum-dried and mixed with the above-mentioned Bupleurum extract, added with 60 g of acesulfame potassium and 1400 g of soluble starch, mixed evenly, made into granules, dried, and made into 2000 g to obtain final product. 4 grams per bag.

Embodiment 3

[0030] Prescription: Bupleurum 2500g Scutellaria baicalensis extract 180g

[0031] Preparation method: decoct the above two flavors, Bupleurum bupleurum with water twice, add 10 times the amount of water each time, 2 hours each time, combine the decoction, filter, concentrate the filtrate to a clear paste with a relative density of 1.10-1.20, stir Add ethanol until the alcohol content is 60%, let it stand for more than 12 hours, filter, recover ethanol from the filtrate, concentrate to an appropriate amount; take the extract of Scutellaria baicalensis, add appropriate amount of water to stir, add 20% sodium hydroxide solution to adjust the pH value to extract Scutellaria baicalensis The substance is completely dissolved, filtered, vacuum-dried and mixed with the above-mentioned Bupleurum extract, added 400g of xylitol, 500g of dextrin, mixed, made into granules, dried, made into 1000g, and obtained. 2 grams per bag.

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PUM

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Abstract

The invention relates to sugar-free type Chaihuang granules and a preparing method thereof. The sugar-free type Chaihuang granules are characterized in that 2500g of radix bupleuri, 180g of baikal skullcap root extract, a flavoring agent and a right amount of auxiliary materials and the like are prepared into the sugar-free type Chaihuang granules; and each bag of sugar-free type Chaihuang granules contains 0.30 to 0.40g of baikal skullcap root extract calculated according to baicalin (C21H18O11). The sugar-free type Chaihuang granules disclosed by the invention have the following advantages that: the sugar-free type Chaihuang granules do not contain cane sugar, and the condition of obesity can not be caused after long-time taking; the sugar-free type Chaihuang granules contain the flavoring agent, the mouth feel of an original recipe is kept, and the sugar-free type Chaihuang granules are especially suitable for children to take; the procedure of a preparing process is definite, the operation is easy, the quality is controllable, and the industrialized production is easy; and the sugar-free type Chaihuang granules have extensive application range and can also be used by patients avoiding eating sugar, such as diabetics and the like.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine granule preparations, and in particular relates to a sugar-free Chaihuang granule and a preparation method thereof. technical background [0002] Chaihuang granule comes from the tenth volume of traditional Chinese medicine preparations issued by the Ministry. The State Food and Drug Administration issued a revised standard in 2008, the standard number: WS3-B-2009-95-2008. [Prescription] Bupleurum 1250g, Scutellaria baicalensis extract 90g; [Preparation method] For the above two flavors, add Bupleurum to decoct twice for 2 hours each time, combine the decoctions, filter, and concentrate the filtrate to a relative density of 1.10-1.20 To clean the ointment, add ethanol under stirring until the alcohol content is 60%, let it stand for more than 12 hours, filter, recover the ethanol from the filtrate, and concentrate to an appropriate amount; take the extract of Scutellaria baica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/539A61K9/16A61P11/00A61P29/00
Inventor 陈兴元
Owner HENAN LINGYOU PHARMA
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