Emulsion-type liquid composition for oral cavity, and process for production thereof

A composition and emulsification-type technology, which is applied in oral care, drug combination, cosmetic preparations, etc., can solve problems such as difficult periodontal disease, halitosis prevention effect, unsatisfactory appearance stability of preparations, and difficulty in fully exerting bactericidal effect, etc. , to achieve the effect of good appearance stability over time, good appearance stability and high retention

Active Publication Date: 2012-09-05
LION CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Further, in this patent document 1, by emulsifying the oil-soluble active ingredient together, the emulsion is retained on the oral mucosa to improve the retention of the active ingredient. However, since the active ingredient is contained in the emulsion, it is difficult to fully exert its Bactericidal effect, the bactericidal power against biofilm is reduced, it is difficult to say that it has fully exerted the preventive effect on dental caries, periodontal disease, and bad breath
In addition, regarding the appearance stability, the emulsion is easily destroyed during long-term high-temperature storage or low-temperature long-term storage (cryopreservation), and the appearance stability of the preparation is still unsatisfactory. There is still room for improvement in these aspects

Method used

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  • Emulsion-type liquid composition for oral cavity, and process for production thereof
  • Emulsion-type liquid composition for oral cavity, and process for production thereof
  • Emulsion-type liquid composition for oral cavity, and process for production thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0088] Hereinafter, the present invention will be specifically described by way of experimental examples, examples, and comparative examples, but the present invention is not limited to the following examples.

[0089] In the preparation of the liquid oral composition of each example, isopropyl methylphenol (manufactured by Osaka Chemical Industry Co., Ltd.), polyoxyethylene (60) hydrogenated castor oil (manufactured by Nikko Chemical Corporation), polyoxyethylene (80) hydrogenated castor oil Sesame oil (manufactured by Nikko Chemical Corporation), emulsion (average particle size 200nm, NET-TE 50, manufactured by Nikko Chemical Corporation), glycerin (100%, manufactured by Sakamoto Pharmaceutical Co., Ltd.), propylene glycol (manufactured by Asahi Glass Corporation), polyethylene glycol Alcohol #400 (manufactured by Lion Chemical Co., Ltd.), tocopheryl acetate (manufactured by DSM New Trijapan Co., Ltd.), citric acid (manufactured by Fuso Chemical Co., Ltd.), sodium citrate (ma...

experiment example 1

[0099] Liquid oral compositions (mouthwashes) having the compositions shown in Tables 1 to 5 were prepared by a conventional method, and finally the emulsion was dispersed and evaluated as follows. The results are shown in Tables 1-5.

[0100] Appearance stability evaluation:

[0101] Fill 450mL of the liquid oral composition sample into a 450mL PET container (polyethylene terephthalate container manufactured by Yoshino Industry Co., Ltd.), and store it in a thermostat at 50°C for 3 months, or at -10°C After being stored in a thermostat for 3 months, its stability was compared with that of the reference product (initial product of Example 3), and visually judged according to the following criteria.

[0102] Evaluation criteria for appearance stability (50°C, 3 months)

[0103] ⊚: No change in color tone of the preparation was observed.

[0104] ◯: There is no problem although the preparation slightly fades.

[0105] Δ: Discoloration of the preparation occurred.

[0106] ...

experiment example 2

[0114]The periodontal disease-causing biofilm penetrating and sterilizing ability of the liquid oral compositions shown in Tables 1 to 5 was evaluated according to the following method. The results are shown in Tables 1-5.

[0115] Evaluation of biofilm penetration sterilization ability:

[0116] (1) Preparation method of model periodontal disease pathogenic biofilm

[0117] A hydroxyapatite (HA) plate (manufactured by Asahi Optical Co., Ltd.) with a diameter of 7mm x thickness of 3.5mm was treated with human non-irritating saliva filtered through a 0.45μm filter for 4 hours, and used as a carrier for the production of a model biofilm, and a culture medium A solution obtained by dissolving 30 g of TBS medium (manufactured by Difco) in 1 L of pure water and adding 5 mg of hemin (manufactured by Sigma) and 0.5 mg of vitamin K (manufactured by Sigma) was used. To make model biofilms, Streptococcus gordonii strain ATC51656 and Actinomyces naeslundii strain ATCC51655 were used as...

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Abstract

Disclosed is an emulsion-type liquid composition for the oral cavity, which comprises (A) a liquid composition for the oral cavity that contains isopropyl methyl phenol and is substantially ethanol-free, (B) polyoxyethylene hydrogenated castor oil having an E. O. of 40 to 100 moles, (C) (C-1) a decaglycerin monofatty acid ester and (C-2) a trifatty acid glyceryl, and (D) at least one polyhydric alcohol selected from glycerin, propylene glycol and polyethylene glycol having an average molecular weight of 190 to 630, wherein the [(B)+(C-1)]/[(C-2)] ratio is 0.77 to 1.87 by mass, the component (D) is contained in an amount of 5 to 15 mass%, and glycerin is contained in an amount of 0.003 mass% or more. The emulsion-type liquid composition has a high infiltration/sterilization effect on a periodontopathic biofilm, enables high accumulation of isopropyl methyl phenol in the oral cavity, and has good appearance stability and mild irritating properties. Also disclosed is a process for producing the composition, which comprises mixing the components (A), (B) and (D) with one another and adding the component (C) in the form of an emulsion to the resulting mixture.

Description

technical field [0001] The present invention relates to a non-alcoholic emulsified liquid oral composition containing isopropyl methylphenol and a production method thereof. The emulsified liquid oral composition does not mix ethanol, and by mixing a specific emulsion, the It improves the retention of medicinal ingredients in the oral cavity, and exerts a high penetration and bactericidal effect on periodontal disease-causing biofilms. It has good appearance stability during high-temperature and low-temperature storage, and eases the irritation during use. Background technique [0002] Not only periodontal disease, but also dental caries and bad breath are considered to be caused by various bacteria in biofilm. As an effective means of preventing and improving oral diseases, killing biofilm bacteria is important for the prevention of oral diseases, so , nonionic or cationic germicides are mixed into oral care preparations. Among the antibacterial agents mixed in oral care p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/34A61K8/06A61K8/37A61K8/86A61Q11/00
CPCA61K8/345A61K8/347A61K8/375A61K8/39A61K8/86A61P1/02A61P31/04A61Q11/00A61K8/06
Inventor 山口翼野村安雄
Owner LION CORP
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