Preparation method of guiling preparation

A preparation, the technology of Guiling, which is applied in the field of preparation of Guiling preparations, can solve the problems of large dosage, low content of active ingredients, slow drug dissolution, etc.

Active Publication Date: 2012-09-26
JIANGXI HERBI SKY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since Guiling Pills uses the whole crude drug powder as medicine, the dosage is large, 6.5 grams each time, and there are also the disadvantages of low content of active ingredients, slow drug dissolution, low bioavailability, and poor compliance of patients, which affects the clinical practice of the drug curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Ephedra 400g Poppy shell 300g Bitter almond (fried) 200g Walnut kernel 200g

[0016] Schisandra 200g Cardamom 25g

[0017] The above six medicinal materials, cardamom extract the volatile oil by steam distillation, separate the volatile oil and the distilled aqueous solution, and set aside; add 10 times the amount of water to extract the dregs, ephedra, poppy shell, and walnut kernels twice, the first time is 4 hours, and the second time 3h, combine the extracts, filter, combine the filtrate with the distilled aqueous solution, concentrate to the equivalent of 1.0g crude drug per milliliter of solution, add 80% ethanol solution to make the alcohol content reach 45%, let stand overnight, filter, and filtrate Concentrate to a thick paste with a relative density of 1.30 (70°C), and set aside; squeeze the bitter almonds to remove oil, add 3 times the amount of 80% ethanol to reflux for extraction twice, the first time for 2 hours, the second time for 1 hour, and combine the...

Embodiment 2

[0059] Ephedra 400g Poppy shell 300g Bitter almond (fried) 200g Walnut kernel 200g

[0060] Schisandra 200g Cardamom 25g

[0061] The above six medicinal materials, cardamom extract the volatile oil by steam distillation, separate the volatile oil and the distilled aqueous solution, and set aside; add 10 times the amount of water to extract the dregs, ephedra, poppy shell, and walnut kernels twice, the first time is 4 hours, and the second time 2h, combine the extracts, filter, combine the filtrate with the distilled aqueous solution, concentrate to the equivalent of 0.8g crude drug per milliliter of solution, add 95% ethanol solution to make the alcohol content reach 35%, let stand overnight, filter, and filtrate Concentrate to a thick paste with a relative density of 1.40 (70°C), and set aside; squeeze the bitter almonds to remove oil, add 4 times the amount of 85% ethanol to reflux for extraction twice, the first time for 2 hours, the second time for 1 hour, and combine the...

Embodiment 3

[0063] Ephedra 400g Poppy shell 300g Bitter almond (fried) 200g Walnut kernel 200g

[0064] Schisandra 200g Cardamom 25g

[0065]The above six medicinal materials, cardamom extract the volatile oil by steam distillation, separate the volatile oil and the distilled aqueous solution, and set aside; add 8 times the amount of water to extract the dregs, ephedra, poppy shell, and walnut kernels together for 3 times, each time for 2 hours, and combine the extracts, Filtrate, combine the filtrate with the distilled aqueous solution, concentrate until each milliliter of solution is equivalent to 1.5g crude drug, add 70% ethanol solution to make the alcohol content reach 50%, let stand overnight, filter, concentrate the filtrate to a relative density of 1.20 (70°C) thick paste, for later use; squeeze bitter almonds to remove oil, add 3 times the amount of 50% ethanol to reflux extraction with Schisandra chinensis 3 times, each time for 1 hour, combine the extracts, filter, and concentr...

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PUM

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Abstract

The invention discloses a preparation method of a guiling preparation. The guiling preparation is prepared from ephedra, poppy capsule, semen armeniacae amarae (fried), semen juglandis, schisandra chinensis and round cardamom.. The invention is characterized in that the preparation method comprises the following steps of: extracting volatile oil by means of the steam distillation of the round cardamom, for later use; extracting for 2-3 times by adding medical dregs, ephedra, poppy capsule, semen juglandis and water, wherein each time is 2-4hours, merging extracting solutions, filtering, concentrating the filter liquor that each milliliter of the solution is equal to 0..8g-1.5g of crude drug, adding ethanol, so that the ethanol content reaches 35%-50%, standing, filtering, and concentrating the filter liquor to obtain thick paste, for later use; extracting the squeezed and oil-removed bitter almond and schisandra chinensis with 50%-85% ethanol for twice to three times, wherein each time is 1-3hours, merging the extracting solution, filtering, and concentrating the filter liquor to obtain thick paste, for later use; and merging the thick paste, and adding the pharmaceutically acceptable auxiliary materials, to prepare the particles, and adding the round cardamom volatile oil, to prepare the troche or the capsule, so that the guiling preparation can be prepared.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a preparation method of Guiling preparation. Background technique [0002] Guiling pills are recorded in the second volume of traditional Chinese medicine preparations in the "Drug Standards of the Ministry of Health". Converging lung qi, relieving cough and relieving asthma, used to treat asthma due to kidney deficiency, chronic cough due to lung deficiency. Guiling pills are made by directly crushing medicinal materials into fine powder, and then refining honey. Since Guiling Pills uses the whole crude drug powder as medicine, the dosage is large, 6.5 grams each time, and there are also the disadvantages of low content of active ingredients, slow drug dissolution, low bioavailability, and poor compliance of patients, which affects the clinical practice of the drug The play of curative effect. Contents of the invention [0003] The object of the present invention...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61P11/06A61P11/14
Inventor 吴安明严建良吴孔松于肖辉黄经球何杨虎
Owner JIANGXI HERBI SKY CO LTD
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