Bimatoprost eye drops and preparation method thereof

A technology of bimatoprost and eye drops, which is applied in the field of medicine, can solve problems such as waste of raw materials, and achieve the effects of improving product quality, reasonable preparation process, and increased stability

Active Publication Date: 2012-10-10
WUHAN WUYAO SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] In order to achieve the above object, the inventors of the present invention have found through a lot of research that adding nonionic surfactants to bimatoprost ophthalmic preparations can greatly improve its solubility, and can solve the problem of waste of raw materials in the preparation process

Method used

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  • Bimatoprost eye drops and preparation method thereof
  • Bimatoprost eye drops and preparation method thereof
  • Bimatoprost eye drops and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] prescription:

[0039]

[0040] Preparation process: dissolve polyoxyethylene hydrogenated castor oil 60 in water for injection, add bimatoprost, stir, heat to dissolve; take another sodium chloride, benzalkonium chloride, EDTA-2Na, boric acid, borax and dissolve in boiling In the water for injection, stir to dissolve; after cooling to room temperature, combine the two liquids, filter, dilute with water for injection to prepare the full amount, adjust the pH value to 6.5-8.0, filter through a 0.22μm microporous membrane, and aseptically fill in Available in plastic eye drops bottles.

Embodiment 2

[0042] prescription:

[0043]

[0044] Preparation process: dissolve polyoxyethylene hydrogenated castor oil 40 in water for injection, add bimatoprost, stir and heat to dissolve; additionally take sodium chloride, benzalkonium bromide, EDTA-2Na, methyl cellulose, boric acid 1. Dissolve borax in boiling water for injection, stir to dissolve; after cooling to room temperature, combine the two liquids, filter, dilute with water for injection to prepare the full amount, adjust the pH value to 6.5-8.0, and filter through a 0.22 μm microporous membrane. Aseptically filled in plastic eye drops bottles, ready to use.

Embodiment 3

[0046] prescription:

[0047]

[0048] Preparation process: dissolve polyoxyethylene hydrogenated castor oil 35 in water for injection, add bimatoprost, stir and heat to dissolve; additionally take sodium chloride, benzalkonium chloride, sodium metabisulfite, disodium hydrogen phosphate, citric acid Dissolve in boiling water for injection, stir to dissolve; after cooling to room temperature, combine the two liquids, filter, dilute with water for injection to prepare the full amount, adjust the pH value to 6.5-8.0, filter through a 0.22μm microporous membrane, sterile Filled in plastic eye drops bottles, ready to use.

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PUM

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Abstract

The invention discloses a bimatoprost composition. The composition comprises an effective treatment dose of bimatoprost, non-ionic surfactant and a pharmaceutically acceptable carrier; the invention also provides a preparation method for the bimatoprost composition; and by the bimatoprost composition, the problem of low dissolubility of bimatoprost in the preparation process can be solved, the stability of bimatoprost at high temperature is improved, and the forming of relative substances is reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a new prostaglandin anti-glaucoma pharmaceutical preparation, in particular to an eye drop containing bimatoprost and a preparation method thereof. Background technique [0002] Glaucoma is a type of eye disease in which high intraocular pressure (IOP) causes damage to the optic nerve. It is the second most common cause of blindness and the leading cause of irreversible blindness in the world. [0003] The current treatment of glaucoma is aimed at reducing IOP, and the advent of new drug prostaglandin derivatives with high efficiency and no side effects has brought good news to glaucoma patients. Prostaglandin drugs are becoming more and more popular among patients due to their good intraocular pressure-lowering effect and excellent safety. Currently, prostaglandin drugs that have been marketed in China include: latanoprost, travoprost and bimatoprost . [0004] Bimatoprost (Bima...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/5575A61K47/34A61K47/44A61K47/26A61P27/06
Inventor 沈恒于艳春耿海明杨波乔春莲
Owner WUHAN WUYAO SCI & TECH
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