Unlock instant, AI-driven research and patent intelligence for your innovation.

Compositions and methods for detecting and treating implant loosening and osteolysis

A technology for osteolysis and implants, applied in the field of osteolysis and implant loosening, can solve problems such as difficult to detect bone changes in imaging process, high radiation exposure, expensive, etc.

Inactive Publication Date: 2012-10-17
BOARD OF RGT UNIV OF NEBRASKA +1
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the early stages of osteolysis, bone changes are difficult to detect and the imaging procedure is expensive with high radiation exposure, and more sensitive techniques are needed to detect particle-induced early inflammation before massive osteolysis develops

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compositions and methods for detecting and treating implant loosening and osteolysis
  • Compositions and methods for detecting and treating implant loosening and osteolysis
  • Compositions and methods for detecting and treating implant loosening and osteolysis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0057] Materials and methods

[0058] Synthesis of Poly(HPMA-co-APMA)

[0059] N-(2-hydroxypropyl)methacrylamide (HPMA; 1g, 6.98mmol; (1973) Eur.Polymer J., 9:7-14), N-(3-aminopropyl)methacrylamide hydrochloride (APMA, 12.5mg, 0.07mmol, Polysciences, Inc., Warrington, PA ), azobisisobutyronitrile (AIBN, 6.74 mg, 41 μmol, Sigma-Aldrich, Milwaukee, WI), S,S'-bis(a,a'-dimethyl-a"-acetic acid) trithiocarbonic acid Ester (CTA, 6.26 mg, 23.6 μmol, purity > 97%) (Lai et al. (2002) Macromolecules 35: 6754-6) and N-methacryloylaminopropyl fluorescein thiourea (MA-FITC, 4 mg) ( Omelyanenko etc. (1998) J.ControlRelease 53:25-37) is dissolved in 8mL methanol, is placed in the ampoule, and with N 2 Purge for 5 minutes. The ampoules were flame sealed and kept at 40°C in the dark for 48 hours. The product was purified by LH-20 column (GE HealthCare, Piscataway, NJ) to remove unreacted low molecular weight compounds and then lyophilized. The final yield was 0.42 g. The amine content o...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Methods and compositions for detecting, diagnosing, and treating osteolysis and implant loosening are disclosed.

Description

[0001] This application claims priority under 35 U.S.C. §119(e) to U.S. Provisional Patent Application No. 61 / 276,213, filed September 9, 2009. The aforementioned applications are incorporated herein by reference. [0002] This invention was made with Government support under Grant No. R01AR053325 awarded by the National Institutes of Health. The US Government has certain rights in this invention. field of invention [0003] The present invention relates to the field of osteolysis and implant loosening. More specifically, the present invention provides compositions and methods for detecting and treating implant loosening and osteolysis. Background of the invention [0004] Several publications and patent documents are cited throughout this specification to describe the state of the art to which this invention pertains. Each of these citations is hereby incorporated by reference as if set forth in full. [0005] An estimated 1.5 million total arthroplasties are performed ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61C8/00
CPCA61L2430/02A61L2300/44A61L27/54A61L2300/41A61L27/16A61P19/08A61P29/00C08L33/26
Inventor 王东史蒂文·R·戈德林爱德华·V·费林格尔
Owner BOARD OF RGT UNIV OF NEBRASKA