Desumab-loaded artificial bone and preparation method thereof

A technology of denosumab and artificial bone, applied in pharmaceutical formulations, prostheses, drug delivery, etc., can solve the problem of not being able to inhibit tumors, and achieve the effects of inhibiting bone resorption, inhibiting tumor cells, and improving bone quality
CN114533952AActive Publication Date: 2022-05-27THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
Publication Date
2022-05-27

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Abstract

The invention discloses an artificial bone loaded with desumab and a preparation method of the artificial bone. The artificial bone is prepared from carboxymethyl chitosan powder, nano-hydroxyapatite powder, 2-methylimidazole zinc salt and desumab, the mass ratio of the carboxymethyl chitosan powder to the nano hydroxyapatite powder to the 2-methylimidazole zinc salt to the desumab is (2 to 4) to (2 to 4) to (0.05 to 0.2) to (0.12 to 0.72). The artificial bone can be used for treating the osteolytic bone tumor, and plays a biological effect by inhibiting postoperative bone defect local tumor recurrence and metastasis of the osteolytic bone tumor.
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Description

technical field

[0001] The invention belongs to the field of biomedical materials, and relates to an artificial bone loaded with denosumab and a preparation method thereof. Background technique

[0002] Tumor bone defect is a huge bone defect caused by surgery for benign and malignant bone tumors and other diseases, and faces great challenges of difficult repair and tumor recurrence. At present, the commonly used bone repair materials include autologous bone, allogeneic bone and artificial bone. Among them, the source of autologous bone is limited, and it causes secondary trauma to the bone extraction site. Allogeneic bone has the risk of infection and disease, so artificial bone is an important choice.

[0003] At present, no matter autologous bone, allogeneic bone, or conventional artificial bone has no tumor suppressing effect. The commonly used anti-tumor chemotherapy drugs and local radiotherapy have huge toxic and side effects. The development of anti-tumor artificia...

Claims

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