Preparation method of fiber-toughening calcium phosphate-based bone repairing material for 3D printing

Abstract

The invention discloses a preparation method of a fiber-toughening calcium phosphate-based bone repairing material for 3D printing. The method comprises the steps of A, preparation of high-dispersionpolymer fibers, wherein a degradable polymer is dissolved in an organic solvent, diphosphonate is added, and even stirring is conducted for obtaining a polymer solution; the polymer solution is subjected to electrostatic spinning for obtaining the polymer fibers arrayed directionally; then deionized water is used for ultrasound-assisted soaking, folding and freezing in the direction vertical to the directional direction are conducted, cutting is conducted through a slicer at intervals of 5-100 microns, ethyl alcohol ultrasonic fiber dispersion, centrifugation collection and vacuum drying are conducted, and the high-dispersion polymer fibers are obtained; B, preparation of a fiber dispersion solution, wherein the high-dispersion polymer fibers are added to a calcium phosphate bone cement liquid phase with the pH of 7.4, and the fiber dispersion solution with the mass concentration of 1-5% is obtained; C, preparation of the bone repairing material, wherein the fiber dispersion solution is evenly mixed with calcium phosphate bone cement solid phase powder according to the mass ratio of (0.7-1.3):1, and the bone repairing material is obtained. The calcium phosphate-based bone repairingmaterial prepared through the method is good in printability and high in mechanical property.

Description

technical field [0001] The invention relates to a preparation method of a fiber-toughened calcium phosphate-based bone repair material for 3D printing. Background technique [0002] In recent years, bone tissue defect repair materials have gradually become one of the hotspots in material research (W. Habraken, P. Habibovic, M. Epple, M. Bohner, Calcium phosphates in biomedical applications: materials for the future? Materials Today, 19(2016 )69-87.). Among them, calcium phosphate-based bone repair materials have been widely used because their composition is similar to the inorganic components in human bone tissue, and they have excellent biocompatibility. [0003] Due to the complex shape and different sizes of bone defects caused by trauma and disease in clinical practice, the current preparation methods of bone tissue restorations cannot achieve precise control of structural shape and pore structure. exact match. With the use of 3D printing technology, it is possible to...

AI Technical Summary

Problems solved by technology

However, the aspect ratio of the non-woven fiber membrane is small, it cannot form a slender toughening body, and the improvement of toughness is limited; the area of ​​the non-woven fiber membrane of a few millimeters is too large, and the membrane is difficult to disperse evenly, which affects the strength of the material. fluidity, loss of printability

In addition, most fibers have poor surface wettability and poor bonding ability with the matrix, which also leads to their mechanical properties to be improved.