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Application of ginkgoneolic acid in preparing medicines for treating immunological diseases

An immune disease, immune technology, applied in the field of pharmacy, can solve the problem of no reported treatment of immune diseases

Inactive Publication Date: 2012-10-31
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above literatures only reported about liver disease or insecticidal effect, and did not report about the treatment of immune diseases, especially about enteritis

Method used

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  • Application of ginkgoneolic acid in preparing medicines for treating immunological diseases
  • Application of ginkgoneolic acid in preparing medicines for treating immunological diseases
  • Application of ginkgoneolic acid in preparing medicines for treating immunological diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The pharmacological test of embodiment 1 arketone

[0022] 1) Induction of enteritis in mice

[0023] 24 C57BL / 6 female mice were randomly divided into groups according to body weight, and were divided into high (30 mg / kg) and low (15 mg / kg) dose groups of alkone (purchased from Lichen monopoly of scientific research supplies in Shanghai, with a purity of 99.3%); The blank group and the model group consisted of 4 groups, with 6 rats in each group. Each drug group was administered intragastrically, starting from 3 days before modeling, once a day for 14 consecutive days. The blank group and the model group were given PBS by intragastric administration, except for the blank group, 3.5% DSS (dextran sulfate sodium salt, purchased from MP Company) was added to the daily drinking water of the mice. During the modeling process, the weight of the mice was measured every day and the feces of the mice were observed. After the successful modeling, blood was taken from the eye s...

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Abstract

The invention belongs to the field of pharmacy and particularly relates to application of ginkgoneolic acid in preparing medicines for treating immunological diseases. The application of ginkgoneolic acid in preparing medicine for treating immunological diseases can be used for declaring a new drug in class 1 of chemical medicines particularly in terms of treating in immunological enteritis and widens the application of the compound .

Description

technical field [0001] The invention belongs to the field of pharmacy, and particularly relates to the application of arketone in the preparation of drugs for treating immune diseases. Background technique [0002] Autoimmune enteritis is a clinically frequent and intractable disease, including Crohn's disease and ulcerative colitis. Immune enteritis often occurs from adolescence, and the reported incidence is as high as 4 to 10 / 100,000 people per year. It is difficult to heal for life, and it will develop into various gastrointestinal diseases including intestinal cancer in the later stage, accompanied by a high mortality rate. At present, antibiotics are mainly used to inhibit the intestinal flora clinically, so as to control the disease process, but there is no direct and effective cure method in the treatment process, and the drugs used have strong side effects. [0003] Fraxinellone is a lactone compound extracted from the root bark of Dictamnus dasycarpus. There are...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P37/02A61P1/00A61P19/02A61P3/10A61P9/00A61P21/04
Inventor 徐强吴雪丰孙洋陈功
Owner NANJING UNIV
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