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Medical composite and preparation method, test method and application thereof

An inspection method and a medicinal technology are applied in the preparation of medicinal preparations and in the field of medicinal preparations for treating eye diseases, and can solve the problems of low proportion of phosphate buffer, unsuitable for determination of compound preparations, and high proportion of mobile phase methanol, Achieve unique prescription, improve ocular vascular congestion, and stable quality.

Inactive Publication Date: 2012-11-14
SICHUAN SUNNYHOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Chinese Pharmacopoeia 2005 or 2010 edition also has an HPLC method for the determination of dandelion raw materials, but the proportion of methanol in the mobile phase is high and the proportion of phosphate buffer is low, which is also not suitable for the determination of compound preparations

Method used

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  • Medical composite and preparation method, test method and application thereof
  • Medical composite and preparation method, test method and application thereof
  • Medical composite and preparation method, test method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: Preparation and inspection of eye drops 1 of the composition of the present invention

[0025] Preparation: take the following raw materials by weight: 500g of dandelion, 500g of cassia, 3g of benzalkonium chloride, 20g of borax, 80g of boric acid, 25g of sodium chloride, crush the decoction pieces of cassia seeds into coarse powder, combine with the decoction pieces of dandelion, and extract with 75% ethanol under reflux 3 times, the first time 1.5 hours, the amount of solvent is 8 times the amount of medicinal materials, the second time 1 hour, the amount of solvent is 6 times the amount of medicinal materials, the third time 0.5 hours, the amount of solvent is 4 times the amount of medicinal materials. Combine the extracts and filter, concentrate and recover ethanol, add 8 times the amount of water for injection to dissolve, refrigerate and stand for 48 hours, and then filter. After adding an appropriate amount of benzalkonium chloride and sodium chlori...

Embodiment 2

[0033] Embodiment 2: Preparation and inspection of eye drops 2 of the composition of the present invention

[0034] Take the following raw materials by weight: dandelion 600g, cassia seed 300g, benzalkonium chloride 1.5g, borax 81g, boric acid 69g, sodium chloride 30g, cassia seed decoction slices into coarse powder, merge with dandelion decoction slices, use 95% ethanol, reflux extraction 2 Time, the first 2 hours, the amount of solvent is 10 times the amount of medicinal materials, the second 1 hour, the amount of solvent is 8 times the amount of medicinal materials. Combine the extracts and filter, concentrate and recover ethanol, add 8 times the amount of water for injection to dissolve, refrigerate and stand for 24 hours, and then filter. After adding an appropriate amount of benzalkonium chloride and sodium chloride to dissolve, then add an appropriate amount of borax and boric acid to adjust the pH to 7-9, make up the volume to 10,000ml with water for injection, stir ev...

Embodiment 3

[0042] Embodiment 3: Preparation of eye drops 3 of the composition of the present invention

[0043] Take the following raw materials by weight: dandelion 667g, cassia seed 333g, benzalkonium chloride 2g, borax 69g, boric acid 81g, sodium chloride 20g, cassia seed decoction slices, grind into coarse powder, combine with dandelion decoction slices, and extract twice with 90% ethanol under reflux , the first 2 hours, the amount of solvent is 10 times the amount of medicinal materials, the second 1 hour, the amount of solvent is 8 times the amount of medicinal materials. Combine the extracts and filter, concentrate and recover ethanol, add 8 times the amount of water for injection to dissolve, refrigerate and stand for 24 hours, and then filter. After adding an appropriate amount of benzalkonium chloride and sodium chloride to dissolve, add an appropriate amount of borax and boric acid to adjust the pH to 7-8, make up the volume to 10,000ml with water for injection, stir well, re...

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Abstract

The invention relates to a medical preparation, in particular to a medical preparation for treating eye diseases, and further to a preparation method, a test method and an application of the medical preparation. The medical preparation comprises, by weight, 200-1000 parts of dandelion, 100-600 parts of semen cassia and pharmaceutically acceptable excipients. The medical preparation is prepared according to a unique formula and is scientific in ingredient proportion. Various medical preparations, especially medical preparation for treating eye diseases, can be prepared since extracting and purifying processes are optimized. The finished preparation products are tested by various test methods, so that the products are stable in quality with various indexes improved greatly. In addition, the medical preparation has effects of clearing heat, improving eyesight, resolving toxin and dispersing swelling and resisting inflammatory, can be used for treating eye drying, pain, blurred vision or red and swollen eyes, and particularly can suppress or treat staphylococcus aureus conjunctivitis or conjunctivitis and improve various symptoms such as congestion of eye blood vessels, eye swelling or generation of excessive secretes.

Description

technical field [0001] The invention relates to a composition, in particular to a pharmaceutical preparation made from the composition with traditional Chinese medicine as the main raw material, especially a medicinal preparation for treating eye diseases. The present invention also relates to the preparation method, testing method and application of the pharmaceutical preparation. Background technique [0002] In the traditional usage of traditional Chinese medicine, the composition consisting of one or more kinds of Chinese medicine raw materials is basically taken after adding water and decocting, instead of extracting and refining them to make ophthalmic preparations. There is no disclosure in the prior art that the composition containing the traditional Chinese medicine raw materials dandelion and cassia seed is extracted and refined to make a pharmaceutical preparation for treating eye diseases, especially an ophthalmic preparation. [0003] CN101284048A discloses a p...

Claims

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Application Information

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IPC IPC(8): A61K36/482G01N30/90G01N30/02A61P27/02
Inventor 郭成辉廖远征黄筱萍颜霞
Owner SICHUAN SUNNYHOPE PHARM CO LTD
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