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Novel delivery assisting gel and preparation method and application of novel delivery assisting gel

A technology of gel and lubricating effect, applied in the field of new delivery aid gel, which can solve the problems of weakening the lubricating effect of lubricant compositions, increasing local and systemic infections, and poor lubricating effects of compositions

Active Publication Date: 2012-11-21
山西纳德西生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] However, the disadvantage is that, on the one hand, because the puerpera will have physiological fluids such as amniotic fluid and blood to flow out from the birth canal during childbirth, the lubricating effect of the lubricant composition will often be weakened. It is easy to clean, but has a better affinity for natural ingredients with lubricating properties, and will not weaken its lubricating effect with physiological body fluids. Therefore, the lubricating effect of the composition provided by the above technical solution is not good; and on the other hand, the reality The situation is that because the immune level of the mother and fetus is very low during childbirth, the birth canal will be bleeding and an episiotomy is often performed, and the chances of local and systemic infection are very likely to increase during childbirth. Therefore, midwifery lubricants It is very important to have high-efficiency lubricating effect, safety and antibacterial properties, but the use of antibiotic chemicals in midwifery lubricants is often harmful to babies, and even very dangerous

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0117] Example 1. A kind of gel -assisted gel, contains:

[0118] Shell glycogen (30 ~ 40MPa.s viscosity model) 1g,

[0119] Polyettene-400 10g,

[0120] 1g of hydroxye ethyl cellulose (80,000 mpa.s viscosity model)

[0121] 10g of glycerin,

[0122] Sodium chloride 0.45g,

[0123] A moderate amount of lactic acid or hydrochloric acid, regulating shell poly gel pH to 3 to 6,

[0124] Purification water is added to 100g;

[0125] Preparation method: (1) Add the chitosan to 30ml of purifying water, stir well, and gradually add an appropriate amount of lactic acid or hydrochloride to form gels, so that the pH value of the gel is 3 to 6, and add sodium chloride to add sodium chloride.Solk, stir well, get the first mixture gel;

[0126](2) Divide the hydroxye ethyl cellulose in the purified water of 40ml. After fully expanding, add glycerin and mix it to get the second mixture gel;

[0127] (3) Merge the above two mixture gel and polyethylene-400, mix well, and adjust the pH to 5 to 6,...

Embodiment 2

[0128] Example 2. A kind of gel -assisted gel, contains:

[0129] Shell glycogen (40MPA.S viscosity model) 1g,

[0130] Polyettene-400 10g,

[0131] 1g of hydroxye ethyl cellulose (80,000 mpa.s viscosity model)

[0132] 10g of glycerin or propylene glycol,

[0133] Sodium chloride 0.45g,

[0134] A moderate amount of lactic acid or hydrochloric acid, regulating shell poly gel pH to 3 to 6,

[0135] Olive oil 0.5g,

[0136] Purification water is added to 100g;

[0137] Preparation method: (1) Add the chitosan to 30ml of purifying water, stir well, and gradually add an appropriate amount of lactic acid or hydrochloride to form gels, so that the pH value of the gel is 3 to 6, and add sodium chloride to add sodium chloride.Dissolt, stir well, and mix well with olive oil to be uniform and equally qualitative to get the first mixture gel;

[0138] (2) Divide the hydroxye ether in the purified water of 40ml. After fully swelling, add glycerin or propylene glycol to get the second mixture...

Embodiment 3

[0140] Example 3. A kind of gel -assisted gel, contains:

[0141] 0.8g of chitosan,

[0142] Polyettene-1000 or polyethylene glycol-400 5g

[0143] Hydroxye ethyl cellulose 1 ~ 3g (depending on different viscosity models),

[0144] Glycerin or proply glycol 12g,

[0145] Sodium chloride 0.44g,

[0146] A moderate amount of lactic acid or hydrochloric acid, regulating shell poly gel pH to 3 to 6,

[0147] Purification water is added to 100g;

[0148] Preparation method: (1) Add the chitosan to 25ml of purified water, stir well, and gradually add an appropriate amount of lactic acid or hydrochloride to form gels, so that the pH value of the gel is 3 to 6, and add sodium chloride to add sodium chloride.Solk, stir well, get the first mixture gel;

[0149] (2) Divide the hydroxye ether in the purified water of 45ml. After fully expanding, add glycerin or propylene glycol to get the second mixture gel;

[0150] Take off and sterilize, that is, the present invention helps childbirth gel....

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PUM

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Abstract

Disclosed is a composition with a lubricating effect. The composition comprises chitosan, polyethylene glycol, a water-soluble thickener, a humectant and optional water. The composition is used for preparing a medical product used as a lubricant for vaginal delivery, has good safety and antibacterial effects, and can effectively assist delivery, so that delivery is carried out easily, and a delivery birth process and delivery time are shortened.

Description

Technical field [0001] The invention involves the field of pharmaceutical products and involves a new type of gel. It is a composition with good lubrication and antibacterial effects. It is used in particular when giving birth. The invention also involves its preparation methods and applications. Background technique [0002] Maternal delivery is a complicated process. Proved obstetrics and gynecology studies have proved that childbirth is determined by three factors such as childbirth (fetus, amniotic membrane, placenta), birth canal, and discipline.Gravity, and the force of suppressing childbirth is the resistance of the uterine mouth and the birth canal. The childbirth of human babies is divided into three stages: the opening period, delivery period, and postpartum production period.The average duration duration of the first maternal childbirth is 12 hours, and the average duration of the normal childbirth of the mother is 8 hours. Compared with the first maternal, the shorter...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/04A61L31/14
Inventor 张耿元赵海静白东跃
Owner 山西纳德西生物科技有限公司
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