Applications of vorinostat in aspect of drugs for treating autoimmune diseases and inflammatory diseases
An autoimmune, vorinostat technology for allergic diseases, blood diseases, sensory diseases, etc.
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Embodiment 1
[0023] 1.1 The construction principle of experimental autoimmune encephalomyelitis (EAE) mouse model
[0024] Myelin oligodendrocyte glycoprotein (MOG 35-55 ) MEVGWYRSPFSRVVHLYRNGK was used as an antigen to immunize C57BL / 6 mice to establish MOG 35-55 - EAE (Experimental Autoimmune Encephalomyelitis) mouse model. Commonly used allergens in the laboratory are mostly brain or spinal cord tissue homogenate, myelin basic protein components or their polypeptide fragments, etc. Most of the immunized objects are rodents to build EAE models. Different allergens can produce different symptoms. For the EAE model, different allergens and different immunized objects can be selected according to the type of EAE model to be established. Although the myelin oligodendrocyte glycoprotein used in this experiment has very little content in the myelin protein, accounting for only 0.01%-0.05% of the myelin protein composition, but because MOG exists in the myelin sheath membrane and oligodendroc...
Embodiment 2
[0082] Mix 50g of vorinostat raw material with 280g of starch evenly, make granules with starch slurry (take 220g of starch to make starch slurry with water), sieve, dry, and pack into capsules.
Embodiment 3
[0084] Mix 80g of vorinostat raw material with 340g of starch evenly, use starch slurry (take 210g of starch to make starch slurry with water), make granules, sieve, dry, add 6‰ magnesium stearate, mix well, press into tablets, and wrap film Get the clothes.
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