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For encapsulation no/n with prior decontamination and rinse steps 2 mixture method

A mixture, premix technology, applied in the geometry/arrangement/dimension of container structure, drug device, container filling method, etc., can solve the problem of NO/N2 mixture not conforming to specifications, waste, etc.

Active Publication Date: 2016-09-07
LAIR LIQUIDE SA POUR LETUDE & LEXPLOITATION DES PROCEDES GEORGES CLAUDE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In other words, if the internal volume of the cylinder is not properly purged and cleaned, the resulting NO / N 2 The mixture will not meet specifications and will be scrapped

Method used

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  • For encapsulation no/n with prior decontamination and rinse steps <sub>2</sub> mixture method
  • For encapsulation no/n with prior decontamination and rinse steps <sub>2</sub> mixture method

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0041] figure 1 Schematically shows the packaged gaseous NO / N that can be applied to the present invention 2 An example of an encapsulation loop in the context of a mixture method.

[0042] As can be seen, this packing cycle consists of several sequential steps, spaced in time from T0 to T13, applicable to each cylinder and detailed below. Successive steps a) to c) of the method of the invention have been figure 1 shown in .

[0043] Between T0 and T1, the flexible hose of the device is communicated with the outside air, that is to say the inner volume of the flexible filling hose is placed in fluid communication with the ambient atmosphere in order to remove any possible residual pressure rise. During this phase, one or more valves of the gas containers connected to the hoses are closed so that there is no gas exchange with the one or more containers. This corresponds to step d) of the method.

[0044] Between T1 and T2, a vacuum pump is used to bring the inside of the f...

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PUM

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Abstract

The invention relates to a method for enclosing a gaseous NO / N2 mixture in at least one container, characterized in that said at least one container undergoes at least a purification step, a draining step and a gas flushing step, during said purging step, placing the interior volume of the vessel in fluid communication with the ambient atmosphere, during said venting step, placing the interior volume of the vessel under reduced pressure, during said gas flushing step, allowing An inert gas enters the at least one container. Preferably, the final gaseous NO / N2 mixture comprises an NO content less than or equal to 1200 ppm (volume) at a pressure between P1 and 800 bar.

Description

technical field [0001] The invention relates to a method for converting gaseous NO / N 2 A method of encapsulating the mixture in containers, in particular one or more cylinders, comprising various successive steps of purging and gas flushing. Background technique [0002] Gaseous NO / N 2 The mixture is commonly used to treat pulmonary vasoconstriction in adults or children, especially newborns with primary pulmonary hypertension or patients who have undergone heart surgery. [0003] These NO / N 2 The mixture is usually enclosed in steel cylinders / cylinders. Typically, these vats / bottles contain from 100 to 1000 ppm (volume) of NO with the remainder being nitrogen (N 2 ). These tanks typically have a water capacity of 2 to 50 liters, which means that these tanks can hold a total fill of up to 15m 3 NO / N 2 mixture. [0004] The encapsulation of these mixtures, that is to say the filling of the cylinders with these mixtures, is done at the gas filling centre. [0005] How...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J19/14F17C5/06
CPCF17C2227/044F17C5/002F17C2201/056F17C2201/058F17C2203/0639F17C2221/014F17C2223/0161F17C2225/0123F17C2225/036F17C2227/0135F17C2227/0311F17C2265/01F17C2270/025F17C2270/059
Inventor P·德 维尔默尔J·萨米兰特C·泽尔比纳蒂
Owner LAIR LIQUIDE SA POUR LETUDE & LEXPLOITATION DES PROCEDES GEORGES CLAUDE