Applications of basic fibroblast growth factor in preparation of drugs for treatment of spinal cord injuries

A technology of fibroblasts and growth factors, applied in the field of medicine, can solve the problem of lack of therapeutic and/or preventive drugs for spinal cord injury, and achieve obvious therapeutic and/or preventive effects

Inactive Publication Date: 2013-01-02
WENZHOU MEDICAL UNIV
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Problems solved by technology

[0009] Contemporary medicine still lacks effective tr

Method used

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  • Applications of basic fibroblast growth factor in preparation of drugs for treatment of spinal cord injuries
  • Applications of basic fibroblast growth factor in preparation of drugs for treatment of spinal cord injuries
  • Applications of basic fibroblast growth factor in preparation of drugs for treatment of spinal cord injuries

Examples

Experimental program
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Embodiment Construction

[0012] Example 1b The therapeutic effect of FGF on rats with spinal cord injury caused by experimental extrusion

[0013] Animal model and grouping: 30 SD rats, weighing 220-250 g, female. The spinal cord injury rat model was made by the following method: 10% chloral hydrate 3.5ml / kg intraperitoneal anesthesia. The limbs of the rats were fixed in prone position, and a posterior midline incision was made on the back. Cut the skin and subcutaneous tissue, expose and bite off the cone plate and spinous process of T8-T10. A 15g arterial clip was used to compress the spinal cord for 2 minutes, and the lower limbs showed flaccid paralysis after waking up from anesthesia. Cefazolin for injection 50 mg / kg intraperitoneal injection was given 7 days after the operation twice a day, and the rats were artificially defecated twice a day.

[0014] The animals were randomly divided into 3 groups (10 rats in each group): sham operation group: only received T8-T9 laminectomy, and the lower ...

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Abstract

The invention belongs to the technical field of medicine, and specifically relates to applications of basic fibroblast growth factor (bFGF) in preparation of drugs for treatment of spinal cord injuries, wherein the spinal cord injuries comprise spinal cord primary injuries and spinal cord secondary injuries caused by various factors. According to the applications of the bFGF in preparation of the drugs for treatment of spinal cord injuries, the form of the drugs can comprise a powder injection, a water agent, a liposome, and the like. With the bFGF, endoplasmic reticulum stress can be inhibited, and spinal cord neuron apoptosis caused by endoplasmic reticulum can be reduced so as to provide a treatment effect for spinal cord injuries.

Description

Technical field: [0001] The invention belongs to the technical field of medicine, and specifically relates to the application of basic fibroblast growth factor (bFGF) in the preparation of medicines for treating spinal cord injury, including the treatment of primary spinal cord injury and secondary injury caused by various factors. Background technique: [0002] Spinal cord injury (SCI) is a severe trauma to the nervous system, which usually leads to severe neurological dysfunction and disability, which not only affects the patient's personal physiology and psychology, but also imposes a heavy burden on the family and society. There are tens of thousands of paralyzed patients with spinal cord injury in the world, and more than one million in my country. According to statistics, the United States adds more than 10,000 injured and sick people every year. In my country, the incidence of spinal cord injury in Beijing alone is about 800 people per year, which has become one of the...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61P25/28
Inventor 肖健李校堃张宏宇张谢王周光王晓杰
Owner WENZHOU MEDICAL UNIV
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