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Method for manufacturing Shuanghuanglian oral liquid

A technology for Shuanghuanglian oral liquid and oral liquid, which is applied in the field of production of Shuanghuanglian oral liquid, can solve the problems of insufficient extraction of active ingredients of medicinal materials and high production cost, achieve improved clarity and stability, optimize production process, reduce The effect of production costs

Active Publication Date: 2013-01-16
HARBIN PHARM GROUP SANJING PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the limitation of the production process in the early years, the extraction of the active ingredients of the medicinal materials was insufficient and the production cost was high.

Method used

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  • Method for manufacturing Shuanghuanglian oral liquid
  • Method for manufacturing Shuanghuanglian oral liquid
  • Method for manufacturing Shuanghuanglian oral liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Formula

[0022]

[0023] (2) Preparation process

[0024] After soaking honeysuckle in water for 30 minutes, decoct twice, 2 hours each time, combine the decoction, filter, and concentrate the filtrate to a clear paste with a relative density of 1.22 at 75°C. After cooling, slowly add ethanol to make the alcohol content reach 70 %, stir well, let it stand for 12 hours, filter the supernatant, adjust the pH value to 7.1 with sodium hydroxide solution, add an appropriate amount of 75% ethanol to the residue, stir well, let stand for 12 hours, filter, combine the ethanol solution, and recover Ethanol until there is no alcohol smell, add 9 times the amount of water to sink, filter, concentrate the filtrate, dry under reduced pressure, grind into fine powder, and obtain the honeysuckle extract.

[0025] After soaking the forsythia in water for 30 minutes, decoct twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, filter, and concent...

Embodiment 2

[0029] (1) Formula

[0030]

[0031] (2) Preparation process

[0032] After soaking honeysuckle in water for 30 minutes, decoct twice, 2 hours each time, combine the decoction, filter, and concentrate the filtrate to a clear paste with a relative density of 1.23 at 76°C. After cooling, slowly add ethanol to make the alcohol content reach 65 %, stir well, let it stand for 12 hours, filter the supernatant, adjust the pH value to 7.0 with sodium hydroxide solution, add an appropriate amount of 75% ethanol to the residue, stir well, let stand for 12 hours, filter, combine the ethanol solution, and recover Ethanol until there is no alcohol smell, add 8 times the amount of water to sink, filter, concentrate the filtrate, dry under reduced pressure, grind into fine powder, and obtain the honeysuckle extract.

[0033] Soak the forsythia in warm water for 30 minutes, decoct twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, filter, and concentrate...

Embodiment 3

[0037] (1) Formula

[0038]

[0039] (2) Preparation process

[0040] After soaking honeysuckle in water for 30 minutes, decoct twice, 2 hours each time, combine the decoction, filter, and concentrate the filtrate to a clear paste with a relative density of 1.21 at 74°C. After cooling, slowly add ethanol to make the alcohol content reach 75 %, fully stirred, let stand for 12 hours, filter the supernatant, adjust the pH value to 7.2 with sodium hydroxide solution, add an appropriate amount of 75% ethanol to the residue, stir well, let stand for 12 hours, filter, combine the ethanol solution, and recover Ethanol until there is no alcohol smell, add 7 times the amount of water to sink, filter, concentrate the filtrate, dry under reduced pressure, grind into fine powder, and obtain the honeysuckle extract.

[0041] After soaking the forsythia in water for 30 minutes, decoct twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, filter, and concen...

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Abstract

The invention provides a method for manufacturing Shuanghuanglian oral liquid. 1000mL of the oral liquid comprises 350-400g of honeysuckles, 350-400g of radix scutellariae, 700-800g of forsythia and 300-400g of cane sugar. The method includes extracting the honeysuckles and the forsythia via aqueous extraction, ethanol precipitation and aqueous precipitation processes, and extracting the radix scutellariae by an aqueous extraction process; mixing honeysuckle extracts, radix scutellariae extracts and forsythia extracts according to a formula to obtain a mixture; adding the balance water into the extracts; stirring uniformly to obtain a mixture; adjusting a pH (potential of hydrogen) value of the mixture by using sodium hydroxide solution; stirring uniformly; filtering; removing sediments in filtrate by 5% of 101-clarifying agents and auxiliary suspension; adding the cane sugar in the filtrate; stirring so that the cane sugar is dissolved to obtain a mixture; adjusting a pH value of the mixture by using sodium hydroxide solution; adding the balance water to dilute the mixture so as to obtain liquid medicine; stirring uniformly, filtering; bottling; and sterilizing to obtain the oral liquid. Compared with the traditional process, the method has the advantages that extraction rates of various index components are increased to different degrees owing to a novel process, the clarity and the stability of the oral liquid are effectively improved, production cost is lowered, and the method for manufacturing the Shuanghuanglian oral liquid is applicable to industrial production.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method for producing Shuanghuanglian oral liquid. Background technique [0002] Shuanghuanglian oral liquid is an antibacterial and antiviral pure traditional Chinese medicine preparation refined from honeysuckle, scutellaria baicalensis and forsythia as main raw materials. It has the effects of dispelling wind and relieving exterior, clearing heat and detoxifying. For colds caused by exogenous wind-heat, symptoms include fever, cough, and sore throat. The combination of honeysuckle, baicalin, and forsythia is a classic prescription of traditional Chinese medicine. Honeysuckle has antibacterial, antiviral, anti-inflammatory, antipyretic, and immune-regulating effects; Scutellaria baicalensis has antibacterial, antifungal, antiviral, anti-inflammatory, anti-allergic effects. Shuanghuanglian oral liquid is a traditional Chinese medicine compound preparation record...

Claims

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Application Information

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IPC IPC(8): A61K36/68A61K9/08A61P11/04A61P11/14A61P29/00A61P31/04A61P31/12
Inventor 刘占滨刘春凤秦雅英范宁吕艳春金焱
Owner HARBIN PHARM GROUP SANJING PHARMACEUTICAL CO LTD
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