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Preparation method of wild chrysanthemum extract

A wild chrysanthemum extract and a technology of wild chrysanthemum, which are applied in the direction of medical preparations containing active ingredients, drug combinations, and pharmaceutical formulas, can solve the problems of unsatisfactory industrial production and low total flavonoid content, and achieve manufacturing cost reduction and production Low equipment requirements, good targeted effect

Inactive Publication Date: 2013-02-13
哈药集团中药二厂
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  • Abstract
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Problems solved by technology

[0004] The present invention aims to solve the problem that the wild chrysanthemum extract prepared by the existing wild chrysanthemum extract used in industrial production is mostly crude extract, the total flavonoid content in the extract is low, and cannot meet the requirements of industrial production, and provides A kind of preparation method of wild chrysanthemum extract

Method used

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specific Embodiment approach 1

[0014] Specific embodiment one: the preparation method of a kind of wild chrysanthemum extract of this embodiment is specifically prepared according to the following steps:

[0015] 1. Take the wild chrysanthemum Chinese medicinal material and decoct it for 3 times with deionized water, 1 hour each time. Chrysanthemum Chinese herbal medicine 12-16 times, the quality of the third deionized water is 12-16 times that of wild chrysanthemum Chinese herbal medicine, combined three times of decoction, and then concentrated to 70 ℃ relative density of 1.10-1.14 clear paste;

[0016] 2. Add water to the clear ointment obtained in step 1. The mass ratio of the volume after adding water to the wild chrysanthemum Chinese herbal medicine is 2L: 1kg, and then adjust the pH value to 6.5-7.0 with a sodium hydroxide solution with a mass concentration of 10%, and let it stand 12h~24h, collect the supernatant, then adjust the pH value to 2.0~3.0 with hydrochloric acid solution, and then let sta...

specific Embodiment approach 2

[0021] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the quality of deionized water for the first time is 18 ~ 19 times of the wild chrysanthemum Chinese medicinal material, and the quality of the second deionized water is that of the wild chrysanthemum Chinese medicinal material 14~15 times, the quality of the third deionized water is 14~15 times that of wild chrysanthemum Chinese medicinal materials. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0022] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is: the mass concentration of the hydrochloric acid solution described in step two is 5%. Others are the same as in the first or second embodiment.

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Abstract

The invention relates to a preparation method of an extract, in particular to a preparation method of a wild chrysanthemum extract. The invention aims at solving the problems that the wild chrysanthemum extract prepared by the conventional preparation method for industry production mostly is a crude extract with low content of general flavone and can not meet the requirement of industrialized production. The preparation method comprises the following steps: I, wild chrysanthemum Chinese medicinal plant is boiled in deionized water to get concentrated clear paste; II, water is added to the clear paste, the PH value is adjusted and the upper layer liquid is collected; III, ethanol eluant is collected; and IV, ethanol is recovered, PH value is adjusted, the liquid is concentrated, the pressure is reduced and wild chrysanthemum extract is obtained. The extract obtained through the method provided by the invention has a high yield rate of 2.5%, and the obtained wild chrysanthemum extract contains more than 80% of general flavone contents, calculated by anhydrous rutin (CHO). The invention is used for preparing wild chrysanthemum extract, and the wild chrysanthemum extract can be used as raw materials for traditional Chinese medicine injection or oral liquid.

Description

technical field [0001] The invention relates to a preparation method of an extract. Background technique [0002] Wild chrysanthemum is the dry flower head of Chrysanthemum indicum L. in Compositae, which is recorded in "Chinese Pharmacopoeia 2010 Edition One" on page 295. It has the effects of clearing heat and detoxifying, purging fire and calming liver. For small sore carbuncle, conjunctival congestion and swelling pain, headache and dizziness. In recent years, with the rapid development of modern extraction, separation, spectroscopy and modern pharmacology, the research on the chemical constituents and biological activities of Chrysanthemum genus has become more and more in-depth. According to chemical analysis, its main components are flavonoids, phenolic acids and terpenes, which are the material basis for its pharmacological activity. Modern pharmacological studies have confirmed that the pharmacological effects of wild chrysanthemum extracts are extensive: (1) Hea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/287A61P7/02A61P9/10A61P9/12A61P31/00
Inventor 刘文亮赛春梅秦绪江曲林凌雪宇单钰毓李殿明王英新
Owner 哈药集团中药二厂
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