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Application of Fructus Aurantii Immaturus total flavonoid extract in preparation of drug treating bronchial asthma

A technology of total flavonoids and extracts of Citrus aurantii, which is applied in the field of traditional Chinese medicine development, can solve the problems of refractory effects, small side effects, complex pathogenesis of asthma, etc., and achieve good pharmacological activity, few side effects, and anti-asthma pharmacological activities.

Active Publication Date: 2015-01-07
和光中药科技(天津)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, with the in-depth development of techniques such as molecular biology, immunology, cell biology, and pathology, the research on the pathogenesis of asthma has been gradually clarified. Airway mucosal edema, inflammatory cell infiltration, and intraluminal mucus plug obstruction are important mechanisms for the pathogenesis of asthma. The theory of airway inflammation has been widely recognized by countries around the world. Therefore, inhibiting the migration and activation of inflammatory cells and the production of cytokines As well as the release of inflammatory mediators, it may become a new treatment direction. The pathogenesis of asthma is complex, and modern pharmacotherapy based on molecular biology is still difficult to effectively play a therapeutic role in some fields, and Chinese patent medicines have little side effects. , can play a multi-component, multi-target, multi-level overall treatment advantage with different pathological links of bronchial asthma, so finding anti-asthma drugs from natural plants is a hot spot in current drug research
At present, there is no research on the application of the total flavonoid extract of Citrus aurantium in the treatment of asthma

Method used

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  • Application of Fructus Aurantii Immaturus total flavonoid extract in preparation of drug treating bronchial asthma
  • Application of Fructus Aurantii Immaturus total flavonoid extract in preparation of drug treating bronchial asthma
  • Application of Fructus Aurantii Immaturus total flavonoid extract in preparation of drug treating bronchial asthma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035]Take 2 kg of citrus citrus decoction pieces, extract three times under reflux with water, add water times (weight) to 12, 10, and 10 times in turn, each time for 1 hour, filter, combine the three extracts, recover the solvent, concentrate to a relative density of 1.15, add ethanol Make its alcohol content reach 75% (volume / volume), leave standstill 12 hours, centrifuge, cross the HPD300 type macroporous adsorption resin after supernatant reclaims ethanol, use 4 times of volume (BV) water successively to elute to no color, discarded, and then eluted with 4 times the volume (BV) of water and 30% (volume / volume) ethanol, collected the ethanol eluate, concentrated, and dried under reduced pressure to obtain the total flavonoids extract of Fructus Aurantii. The total flavonoids contained therein are 86.47% (percentage by weight) in terms of naringin.

Embodiment 2

[0037] Take 2 kg of citrus citrus decoction pieces, extract three times under reflux with water, add 12, 10, and 10 times of water in turn, each time for 1 hour, filter, combine the three extracts, recover the solvent, concentrate to a relative density of 1.15, add ethanol to make it contain Alcohol amount reaches 50% (volume / volume), leaves standstill for 12 hours, centrifuges, after supernatant reclaims ethanol, passes through HPD100 type macroporous adsorption resin, first washes with water until colorless, discards, and then uses 4 times volume volume Elute with 95% (volume / volume) ethanol, collect the ethanol eluate, concentrate, and dry under reduced pressure to obtain the total flavonoids extract of Fructus Aurantii. The total flavonoids contained therein are 72.45% (percentage by weight) in terms of naringin.

Embodiment 3

[0039] Get 2 kg of citrus citrus decoction pieces, extract three times under reflux with water, add 10 times the amount of water, each time for 1 h, filter, combine three extracts, reclaim the solvent, concentrate to a relative density of 1.15, add ethanol to make the alcohol content reach 65% (volume / volume), left standstill for 12 hours, centrifuged, the HPD100 type macroporous adsorption resin was crossed after supernatant reclaimed ethanol, first washed with water to colorless, discarded, and then 50% (volume / volume) of water with 4 times of volume ), the ethanol eluate was collected, concentrated, and dried under reduced pressure to obtain the total flavonoids extract of Fructus Aurantii. The total flavonoids contained therein are 90.32% (percentage by weight) in terms of naringin. Take the obtained total flavonoids extract, add 80g of sucrose, mix evenly, granulate, sieve, and dry, and promptly prepare the medicine in the form of granules containing the total flavonoids...

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Abstract

The invention provides application of a Fructus Aurantii Immaturus total flavonoid extract in preparation of a drug treating bronchial asthma. Experimental results show that the extract can be used for treating bronchial asthma, and the Fructus Aurantii Immaturus total flavonoid extract can substantially reduce the duration of bronchial, the proportion of eosinophils and the serum IgE level. The Fructus Aurantii Immaturus total flavonoid extract can improve the inflammatory morphological change of bronchi and lung tissues, has significant differences compared with a model group, and has the characteristics of fewer side effect and effective treatment in the process of bronchial asthma treatment.

Description

technical field [0001] The invention belongs to the field of research and development of traditional Chinese medicines, and relates to a medicine for treating bronchial asthma, in particular to the total flavonoid extract of Citrus citrus aurantium extracted from the traditional Chinese medicinal material Citrus aurantii and its preparation, which can effectively treat bronchial asthma. Background technique [0002] Bronchial asthma (bronchial asthma, referred to as asthma) is a chronic airway inflammatory disease involving a variety of cells (such as eosinophils, mast cells, T lymphocytes, neutrophils, airway epithelial cells, etc.) and cell components. disease. WHO estimates that there are as many as 300 million people with asthma in the world. In the past 10 years, the morbidity and mortality of asthma have been on the rise. Globally, more than 250,000 people die from asthma every year. With the global air pollution and environmental deterioration, the morbidity and mor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61P11/06
Inventor 张铁军廖茂梁龚苏晓解学星孙卫王丽莉郑雅楠
Owner 和光中药科技(天津)有限公司
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