Application of Fructus Aurantii Immaturus total flavonoid extract in preparation of drug treating bronchial asthma
A technology of total flavonoids and extracts of Citrus aurantii, which is applied in the field of traditional Chinese medicine development, can solve the problems of refractory effects, small side effects, complex pathogenesis of asthma, etc., and achieve good pharmacological activity, few side effects, and anti-asthma pharmacological activities.
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Embodiment 1
[0035]Take 2 kg of citrus citrus decoction pieces, extract three times under reflux with water, add water times (weight) to 12, 10, and 10 times in turn, each time for 1 hour, filter, combine the three extracts, recover the solvent, concentrate to a relative density of 1.15, add ethanol Make its alcohol content reach 75% (volume / volume), leave standstill 12 hours, centrifuge, cross the HPD300 type macroporous adsorption resin after supernatant reclaims ethanol, use 4 times of volume (BV) water successively to elute to no color, discarded, and then eluted with 4 times the volume (BV) of water and 30% (volume / volume) ethanol, collected the ethanol eluate, concentrated, and dried under reduced pressure to obtain the total flavonoids extract of Fructus Aurantii. The total flavonoids contained therein are 86.47% (percentage by weight) in terms of naringin.
Embodiment 2
[0037] Take 2 kg of citrus citrus decoction pieces, extract three times under reflux with water, add 12, 10, and 10 times of water in turn, each time for 1 hour, filter, combine the three extracts, recover the solvent, concentrate to a relative density of 1.15, add ethanol to make it contain Alcohol amount reaches 50% (volume / volume), leaves standstill for 12 hours, centrifuges, after supernatant reclaims ethanol, passes through HPD100 type macroporous adsorption resin, first washes with water until colorless, discards, and then uses 4 times volume volume Elute with 95% (volume / volume) ethanol, collect the ethanol eluate, concentrate, and dry under reduced pressure to obtain the total flavonoids extract of Fructus Aurantii. The total flavonoids contained therein are 72.45% (percentage by weight) in terms of naringin.
Embodiment 3
[0039] Get 2 kg of citrus citrus decoction pieces, extract three times under reflux with water, add 10 times the amount of water, each time for 1 h, filter, combine three extracts, reclaim the solvent, concentrate to a relative density of 1.15, add ethanol to make the alcohol content reach 65% (volume / volume), left standstill for 12 hours, centrifuged, the HPD100 type macroporous adsorption resin was crossed after supernatant reclaimed ethanol, first washed with water to colorless, discarded, and then 50% (volume / volume) of water with 4 times of volume ), the ethanol eluate was collected, concentrated, and dried under reduced pressure to obtain the total flavonoids extract of Fructus Aurantii. The total flavonoids contained therein are 90.32% (percentage by weight) in terms of naringin. Take the obtained total flavonoids extract, add 80g of sucrose, mix evenly, granulate, sieve, and dry, and promptly prepare the medicine in the form of granules containing the total flavonoids...
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