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Medicinal composition containing ciprofloxacin compound and preparation method thereof

A technology of ciprofloxacin hydrochloride and its composition, which is applied in the field of preparation of ciprofloxacin hydrochloride cream, can solve the problems of long treatment period, ineffective effect and expensive medicine costs of patients with decubitus, and achieve the goal of overcoming the problem of treatment Inconvenient, low cost, high efficiency effect

Inactive Publication Date: 2013-03-20
HEFEI YIFAN PHARMA MANAGEMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There are many medicines for treating bedsores on the market, most of which are antibiotics, some are externally used, taken orally, and some are injected, plus some active manual care, but the effect is not very obvious, and it also brings great pain and pain to the patient. Expensive medicine costs; the treatment period for bedsores is long, and the symptoms are more likely to recur

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Formula: ciprofloxacin hydrochloride 0.3%; berberine 10.0%; cetearyl alcohol 10.0%; liquid paraffin 4.0%; white petrolatum 11.5%; ethyl p-hydroxybenzoate 0.05%; glycerin 6.0%; Alkyl sodium sulfate 1.55%; purified water 56.6%; preparation method: take ciprofloxacin hydrochloride and berberine in a 1000ml beaker, add an appropriate amount of purified water to dissolve in a water bath for later use; mix cetostearyl alcohol, liquid paraffin, white Put the vaseline into the oil phase dissolving pot separately, heat it to 100±2°C, and keep it warm for 30 minutes; after the heat preservation is over, put the ethyl p-hydroxybenzoate into the oil phase dissolving pot until it is completely dissolved, then cool it down to 80±2°C for later use ;Put glycerin and purified water into the water phase dissolving pot respectively, when heated to 100°C, keep warm for 30 minutes. Put sodium lauryl sulfate into the water phase dissolving pot. After completely dissolving, cool to 80±2°C fo...

Embodiment 2

[0026] Formula: ciprofloxacin hydrochloride 0.4%; berberine 8.5%; cetearyl alcohol 9.5%; liquid paraffin 3.5%; white petrolatum 10.5%; ethyl p-hydroxybenzoate 0.04%; glycerin 5.0%; Alkyl sodium sulfate 1.45%; purified water 61.11%; preparation method: take ciprofloxacin hydrochloride and berberine in a 1000ml beaker, add an appropriate amount of purified water to dissolve in a water bath for later use; mix cetearyl and stearyl mixed alcohol, liquid paraffin, Put the white vaseline into the oil phase dissolving pot separately, heat it to 100±2°C, and keep it warm for 30 minutes; after the heat preservation is over, put the ethyl p-hydroxybenzoate into the oil phase dissolving pot until it is completely dissolved, then cool down to 80±2°C Standby; put glycerin and purified water into the water phase dissolving pot respectively, heat it to 100°C, and keep it warm for 30 minutes. Put sodium lauryl sulfate into the water phase dissolving pot. After completely dissolving, cool to 8...

Embodiment 3

[0028] Formula: ciprofloxacin hydrochloride 0.35%; berberine 9.0%; cetostearyl alcohol 10.0%; liquid paraffin 4.0%; white petrolatum 11.0%; ethyl p-hydroxybenzoate 0.05%; glycerin 6.0%; dodecane Sodium base sulfate 1.50%; purified water 58.1%. Preparation method: Take ciprofloxacin hydrochloride and berberine in a 1000ml beaker, add an appropriate amount of purified water, heat and dissolve in a water bath for later use; put cetearyl alcohol, liquid paraffin, and white petrolatum into the oil phase dissolving pot respectively, and heat to 100 At ±2°C, keep it warm for 30 minutes; after the end of the heat preservation, put ethyl p-hydroxybenzoate into the oil phase dissolving pot until completely dissolved, then cool to 80±2°C for later use; put glycerin and purified water into the water phase to dissolve In the same pot, when heated to 100°C, keep warm for 30 minutes. Put sodium lauryl sulfate into the water phase dissolving pot. After completely dissolving, cool to 80±2°C ...

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Abstract

The invention relates to a medicinal composition containing ciprofloxacin compound and a preparation method thereof. The composition is cream, and consists of the following ingredients in percentage by weight: 0.3 to 0.4 percent of ciprofloxacin, 8.0 to 10.0 percent of berberine, 9.0 to 11.0 percent of mixed hexadecanol and octadecanol, 3.0 to 5.0 percent of liquid paraffin, 10.0 to 12.0 percent of albolene, 0.05 percent of ethyl p-hydroxybenzoate, 5.0 to 7.0 percent of glycerol, 1.45 to 1.55 percent of lauryl sodium sulfate, and 56.1 to 62.1 percent of purified water. The medicinal composition can effectively treat bedsore, and facilitates nursing. The medicinal composition has smooth appearance and no stimulation or anaphylaxis, is convenient to carry and use, brings comfort to a patient in the using process, and has the advantages of high effective rate, no relapse after cure, low cost and long storage period.

Description

technical field [0001] The invention belongs to the external preparation for treating skin diseases in the field of clinical medicine, and relates to a new preparation method of ciprofloxacin hydrochloride cream. Background technique [0002] Skin wounds are prone to infection but difficult to treat, the treatment cycle is long, and the operation is troublesome. It has always been a major problem in skin clinics. Original ciprofloxacin hydrochloride cream is used to treat impetigo, boils, folliculitis, eczema combined infection, trauma infection, ringworm combined infection and other purulent skin infections; but the treatment effect on bedsores is not obvious . Bed sores are a common disease in bedridden patients for a long time. With the continuous growth of the elderly population, the clinical frequency of decubitus sores is also increasing. It is difficult to treat and care for this disease. It is between the clinical departments of dermatology, orthopedics, internal m...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61K31/4375A61K9/06A61P17/02
Inventor 程先锋
Owner HEFEI YIFAN PHARMA MANAGEMENT
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