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antibacterial composition

A composition and anti-bacterial technology, applied in animal repellents, special packaging items, plant growth regulators, etc., can solve problems such as reducing MEO

Inactive Publication Date: 2015-08-19
TAKASAGO INTERNATIONAL CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the antimicrobial activity of MEO and its main component, allyl isothiocyanate (AIT), have been reported separately in various studies, there is still a need for an antimicrobial composition with improved efficacy that reduces Amount of MEO required for activity

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Brain heart infusion (BHI) agar plates inoculated with E. 7L sealed acrylic box and exposed to trans-2-enal (C 6 -C 11 Carbon chain length) and mustard essential oil (MEO) double combination steam.

[0059] The trans-2-enal and MEO were weighed net and placed into a glass bottle (the glass bottle was placed in a box between the inoculated agar plates). Concentrations of single substances and double combinations introduced into 7L boxes are expressed as weight per unit volume of the box (mg / L). For each organism, several concentrations of single substances and combinations ranging from 0.5 mg / L to 43 mg / L were tested. Vapor-phase minimum inhibitory concentration (MIC) for "no growth" after 3 days of incubation at room temperature. The partial inhibitory concentration (FIC) was determined according to the following formula to evaluate the antibacterial effect of the combination of trans-2-enal and MEO in the gas phase:

[0060] Combined FIC=(trans-2-enal 组合 MIC / tran...

Embodiment 2

[0081] Brain heart infusion (BHI) agar plates inoculated with E. 7L sealed acrylic box and exposed to vapors of the following compositions. A non-steamed control of the agar plates was established.

[0082] Composition A: trans-2-hexenal at 9.3 mg / L

[0083] Composition B: trans-2-heptenal at 9.3 mg / L

[0084] Composition C: 9.3 mg / L of 2,4-heptadienal

[0085] Composition D: trans-2-hexenal at 7.1 mg / L

[0086] Composition E: 7.1 mg / L of 2,4-heptadienal

[0087] Composition F: 7.1 mg / L of 2,4-heptadienal + citronellol (1:1)

[0088] Composition G: 9.3 mg / L of citronellal + citral DMA (1:1)

[0089] Composition H: 9.3 mg / L benzaldehyde + citral DMA (1:1)

[0090] Composition I: 9.3 mg / L furfural + citronellol (1:1)

[0091] Composition J: citral+citronellal (1:1) at 7.1 mg / L

[0092] Composition K: 7.1 mg / L of trans-2-hexenal + citronellol (1:1)

[0093] and get the following result:

[0094] Table 7: Gas phase activity against bacteria

[0095]

[0096] Label: ...

Embodiment 3

[0101] A detergent base was obtained based on a commercially available gel detergent product and used as a positive control. In each test, a positive control was added containing 0.2% by weight of trans-2-nonenal, trans-2-decenal, trans-2-undecenal, trans-2-dodecanal Aromatic composition of aldehydes of alkenal and trans-2-tridecenal.

[0102] The activity log reduction of these compositions against Enterococcus hirae ATCC 10541 and Staphylococcus aureus ATCC 6538 in solution was determined. Dilute with 116 grams of water per 1 gram of product and stir with a stir bar for about 10 minutes. Bacteria were added in one aliquot, mixed on a vortex mixer and placed in a 50°C water bath. After 1 hour, samples were diluted in D / E neutralizing broth (Dey and Engley) and spread on solid medium. Surviving bacteria were counted after 1 day of incubation at 37°C. The results are shown in Table 8 below.

[0103] Table 8: Log reduction in activity of Enterococcus hirae ATCC 10541 and St...

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Abstract

Antimicrobial compositions that include at least one aliphatic aldehyde component and allyl isothiocyanate are provided. Methods of reducing bacterial activity using the instantly disclosed compositions are also provided.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Patent Serial No. USSN 61 / 347,439, filed May 23, 2010, the entire contents of which are incorporated herein by reference. technical field [0003] The disclosed subject matter relates to compositions having antimicrobial activity, and methods of using the compositions to reduce bacterial activity on solids, liquids, or surrounding air spaces. Background technique [0004] Mustard essential oil (MEO) has been described as a defense mechanism against herbivores in cruciferous plants. Although the antimicrobial activity of MEO and its main component, allyl isothiocyanate (AIT), have been reported separately in various studies, there is still a need for an antimicrobial composition with improved efficacy that reduces Amount of MEO required for activity. There also remains a need for antimicrobial compositions effective against Gram-negative and Gram-positive bacteria in the gas p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N33/08A61K31/13
CPCB65B31/00A01N35/02A01N47/46A01N2300/00
Inventor R·KL·康A·T·齐利亚
Owner TAKASAGO INTERNATIONAL CORPORATION
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