Medical application of selenium phosphate compound

A compound, selenium salt technology, applied in the field of medicine, can solve the problem that the attribute requirements of pharmaceutical products cannot be met, etc.

Active Publication Date: 2013-04-17
SHENZHEN F&S BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are still shortcomings in the effective dosage and safe dosage of common selenium agents, which cannot meet the attribute requirements of pharmaceutical products. Therefore, it is of great significance to develop selenium agents with anti-cancer and anti-cancer effects

Method used

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  • Medical application of selenium phosphate compound
  • Medical application of selenium phosphate compound
  • Medical application of selenium phosphate compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Example 1 Preparation of Selenium Phosphate Complex

[0067] Weigh a certain amount of selenium dioxide and potassium tripolyphosphate respectively, wherein the molar ratio of selenium dioxide and potassium tripolyphosphate is 1.8:1. Dissolve the weighed selenium dioxide in water to prepare 0.2g / ml selenous acid, and pour it into the reactor, then slowly add potassium tripolyphosphate into the selenous acid solution, and adjust the temperature to 250~300°C , Stir, after dehydration, deacidification, generate potassium selenium phosphate complex. The complex obtained by the reaction is dissolved in an appropriate amount of water, neutralized with phosphoric acid to a pH of 6.0-6.5, and then heated and dehydrated to obtain a potassium selenium phosphate complex that can be applied to humans or mammals.

[0068] Weigh a certain amount of selenium dioxide and sodium tripolyphosphate respectively, wherein the molar ratio of selenium dioxide and sodium tripolyphosphate is...

Embodiment 2

[0074] Example 2 Characterization of Selenium Phosphate Complexes

[0075] Adopt nuclear magnetic resonance to measure the nuclear magnetic resonance spectrum of the phosphate selenium salt complex that obtains in the above-mentioned embodiment, with phosphoric acid 31 PNMR to determine the delta value of the relative phosphorus signal, i.e. set the phosphorous 31 PNMR δ=0ppm where the potassium selenide phosphate complex 31 PNMR spectrum such as figure 1 shown. Metal ions have little effect on the phosphorus signal, and the 31 The PNMR spectra are similar, and there are phosphorus signal peaks at δ=3.0~2.2ppm and δ=-5.6~-6.8ppm.

Embodiment 3

[0076] Example 3 Study on Acute Toxicity of Potassium Selenium Phosphate Compound

[0077] Sixty SPF-grade Kunming mice were randomly divided into 6 groups according to body weight, with 10 mice in each group, half male and half male. The experiment consisted of blank control group (distilled water), potassium selenium phosphate oral liquid 24.75, 19.80, 15.84, 12.67, 10.14 mg / kg five groups, a total of 6 groups, administered by intragastric administration. Immediately after the administration, observe the reaction of the animals for 12 hours, and then observe once a day for 14 consecutive days.

[0078] Experimental results: Table 1 lists the body weight changes of the mice in the experiment. In the blank control group, no obvious abnormal reaction was found within 14 days, and the body weight increased well. After administration of potassium selenium phosphate oral liquid at a concentration of 24.75mg / kg, the mice immediately experienced decreased activity, dyspnea, limb...

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PUM

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Abstract

The invention provides an application of a selenium phosphate compound-M3(SeP3O10)n.XH2O to preparation of drugs for treating and / or preventing excessive proliferative diseases of humans or mammals. In the chemical formula of M3(SeP3O10)n.XH2O, X ranges from 0 to 4, n is 1 or 2, and M is alkali metal or ammonium ion when n is 1 and is alkali-earth metal when n is 2. In addition, the invention provides an application of the selenium phosphate compound-M3(SeP3O10)n.XH2O to preparation of drugs for preventing and / or treating a selenium deficiency-related human disease such as Keshan disease or cataract. The selenium phosphate compound can be used for treating and / preventing the excessive proliferative diseases of the humans or mammals, and the excessive proliferative diseases comprise various cancers and tumors; and the selenium phosphate compound does have adverse reactions or side effects, improves the survival quality of patients and is very good in compliance.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to the medical application of selenium phosphate compound. Background technique [0002] Since the discovery of selenium as an essential microelement for humans and animals in 1957, scientists have discovered 14 selenoenzymes and selenoproteins, including 4 glutathione peroxidases, 3 thyroxine deiodinases, and 3 selenoproteins. Thioredoxin reductase, selenophosphate synthase 2, selenoprotein w, selenoprotein p, and 15KDa selenoprotein, all of which, except for selenoprotein p, contain only one selenocysteine ​​residue in sequence base (this is the active center site of the enzyme). Selenium enzymes and selenoproteins play an important role in regulating the reduction state of cells and removing excess reactive oxygen species produced in the body. [0003] At present, more and more evidence shows that selenium plays an important role in preventing and fighting cancer. Based on studies in m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/42A61P35/00A61P3/02A61P27/12A61P9/00
Inventor 李福初彭锋
Owner SHENZHEN F&S BIO TECH
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