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Drug composition conducive to improvement of memory and adjunctive treatment of senile dementia

A technology for adjuvant therapy and senile dementia, applied in the fields of medicine and food, can solve the problems of low bioavailability and poor water solubility of Ginkgo biloba extract, and achieve the effects of protecting nerve cells, good prevention and treatment effects, and definite curative effect.

Inactive Publication Date: 2013-04-17
李庆杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Egg yolk lecithin also acts as a preparation auxiliary material in this composition. Perilla seed oil will bring certain difficulties in the preparation process. After the egg yolk lecithin Packing and can solve this problem, and Ginkgo biloba extract has poor water solubility and low bioavailability, and its bioavailability can be improved by wrapping with egg yolk lecithin

Method used

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  • Drug composition conducive to improvement of memory and adjunctive treatment of senile dementia
  • Drug composition conducive to improvement of memory and adjunctive treatment of senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Extraction preparation of the composition

[0030] (1) Take 100g of ginseng and add water to decoct twice, each time add 800ml of water to decoct for 2.0 hours, filter, filtrate, concentrate, dry under reduced pressure at 60°C, and crush to obtain 16.5g of extract;

[0031] (2) Take 200g of ginkgo leaves and extract twice with 70% ethanol under reflux, and add 1200ml of 70% ethanol for 2.0 hours each time. Filtrate, recover ethanol from the filtrate, concentrate, dry under reduced pressure at 60°C, and pulverize to obtain 42 g of extract;

[0032] (3) Take 200g of grape seeds and extract twice with 60% ethanol under reflux, each time adding 1200ml of 60% ethanol for reflux extraction for 2.0 hours. Filtrate, recover ethanol from the filtrate, concentrate, dry under reduced pressure at 60°C, and pulverize to obtain 15.5 g of extract;

[0033] (4) Mix 10g of perilla seed oil and 400ml of ginkgo biloba extract 60% ethanol solution to obtain solution...

Embodiment 2

[0035] Example 2 Extraction preparation of the composition

[0036] (1) Take 300g of ginseng and add water to decoct twice, each time add 2400ml of water to decoct for 2.0 hours, filter, filtrate, concentrate, dry under reduced pressure at 60°C, and crush to obtain 46.5g of extract;

[0037] (2) Take 300g of ginkgo leaves and extract twice with 70% ethanol under reflux, each time add 1800ml of 70% ethanol for reflux extraction for 2.0 hours. Filtrate, recover ethanol from the filtrate, concentrate, dry under reduced pressure at 60°C, and pulverize to obtain 62 g of extract;

[0038] (3) Take 300g of grape seeds and extract 3 times with 60% ethanol under reflux, each time adding 1800ml of 60% ethanol for reflux extraction for 2.0 hours. Filtrate, recover ethanol from the filtrate, concentrate, dry under reduced pressure at 60°C, and pulverize to obtain 23 g of extract;

[0039] (4) Mix 30g of perilla seed oil and 600ml of ginkgo leaf extract 60% ethanol solution t...

Embodiment 3

[0041] Example 3 Extraction preparation of the composition

[0042] (1) Take 200g of ginseng and add water to decoct 3 times, each time add 2000ml of water to decoct for 2.0 hours, filter, filtrate, concentrate, dry under reduced pressure at 60°C, and crush to obtain 33g of extract;

[0043] (2) Take 200g of ginkgo leaves and reflux extract with 95% ethanol for 3 times, each time add 1600ml of 95% ethanol for reflux extraction for 2.0 hours. Filtrate, recover ethanol from the filtrate, concentrate, dry under reduced pressure at 60°C, and pulverize to obtain 38 g of extract;

[0044] (3) Take 200g of grape seeds and extract 3 times with 30% ethanol under reflux, each time add 1200ml of 60% ethanol for reflux extraction for 2.0 hours. Filtrate, recover ethanol from the filtrate, concentrate, dry under reduced pressure at 60°C, and pulverize to obtain 16 g of extract;

[0045] (4) Mix 20g of perilla seed oil and 380ml of 95% ethanol solution of ginkgo biloba leaf ex...

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Abstract

The invention relates to a drug composition conducive to improvement of memory and adjunctive treatment of senile dementia. The drug composition provided by the invention is characterized by being prepared from ginseng, ginkgo leaves, grape seeds, purple perilla seed oil and egg yolk lecithin, and synergistic effects of the components are utilized to prepare oral preparations such as hard capsules, soft capsules, tablets, granules, powder and pills. The drug composition provided by the invention can be applied to a Chinese patent drug or health-care food, and has an effect of being conducive to improvement of memory and adjunctive treatment of senile dementia.

Description

technical field [0001] The invention relates to a pharmaceutical composition which is helpful for improving memory and assisting in treating senile dementia. The invention belongs to the field of medicine and food. Background technique [0002] Alzheimer's disease is a complex disease characterized by advanced cognitive dysfunction, and the pathological features are mainly senile plaques, neurofibrillary tangles and neuronal loss. Affected middle-aged and elderly people have varying degrees of cognitive function decline such as memory, language expression ability, and logical judgment ability, or accompanied by abnormal behaviors such as temper tantrums, mental depression, and tension, and even decline in daily life ability, which seriously affects the quality of life . At present, the incidence rate of the population over 65 years old is about 5%-10%. With the aging of the population, the incidence rate is increasing year by year. Therefore, the understanding and treatment...

Claims

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Application Information

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IPC IPC(8): A61K36/87A61P25/28A23L1/29A23L33/00
Inventor 李庆杰王莲萍
Owner 李庆杰
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