Pharmaceutical composition for treating triple negative breast cancer and application thereof

A technology for triple-negative breast cancer and composition, which can be used in drug combinations, anti-tumor drugs, etc., can solve the problems of strong invasiveness, high recurrence and metastasis rate, and insensitivity of triple-negative breast cancer

Inactive Publication Date: 2013-05-15
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Triple-negative breast cancer is highly invasive, has a high rate of recurrence and metastasis, is insensitive to endocrine and targeted therapy, and has a poor prognosis. It is one of the biggest challenges facing breast cancer treatment in the world.
There is no report about the pharmaceutical composition composed of thiazolidinedione and hydralazine and its application in the treatment of triple negative breast cancer

Method used

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  • Pharmaceutical composition for treating triple negative breast cancer and application thereof
  • Pharmaceutical composition for treating triple negative breast cancer and application thereof
  • Pharmaceutical composition for treating triple negative breast cancer and application thereof

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Embodiment Construction

[0030] The specific implementation manners provided by the present invention will be described in detail below with reference to the accompanying drawings.

[0031] 1. The expression of PPARγ in breast cancer

[0032] 1. The expression of PPARγ in different types of breast cancer tissues

[0033] According to genetic markers, breast cancer can be divided into four types, namely luminal A type (ER+ / PR+ / Her-2-), luminal B type (ER+ / PR+ / Her-2+), and HER2 type (ER- / PR- / Her-2+) and triple negative (ER- / PR- / Her-2-). The immunohistochemical method was used to detect the expression level of PPARγ in 120 cases of breast cancer tissues of different histological types. The results are as follows figure 1 , The results showed that in the four different types of breast cancer tissues, the positive expression rates were triple negative 22% (P <0.001, compared with luminal A type), luminal A type 46%, luminal B type 39% (P=0.741, compared with luminal A type), HER2 type 35% (P=0.469, compared wi...

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Abstract

The invention discloses a pharmaceutical composition for treating a triple negative breast cancer and application thereof. The pharmaceutical composition is prepared from thiazolidinedione and hydralazine. Application of the pharmaceutical composition in preparation of a medicament for treating a disease of the triple negative breast cancer, application of preparation in the medicament for improving PPAPgama protein and PPAPgammanRNA expression in triple negative breast cancer cell, application in preparation of the medicament for restraining cell multiplication of the triple negative breast cancer, and application in preparation of the medicament for promoting cell apoptosis of the triple negative breast cancer are also provided by the invention. A new way of thinking is brought about for treatment of a sufferer with the triple negative breast cancer by the pharmaceutical composition and the application thereof provided by the invention; and a new application field of the pharmaceutical composition is developed.

Description

technical field [0001] The invention relates to a pharmaceutical composition and its application, in particular to a pharmaceutical composition for treating triple-negative breast cancer and its application. Background technique [0002] Triple-negative breast cancer is highly invasive, has a high recurrence and metastasis rate, is insensitive to endocrine and targeted therapy, and has a poor prognosis. It is one of the biggest challenges facing breast cancer treatment in the world. Therefore, finding effective therapeutic targets for the special biological behavior of triple-negative breast cancer has become the focus of common attention of scholars and clinicians from all over the world in recent years. A large number of studies have shown that PPARγ plays an important role in the occurrence and development of breast cancer, and has become one of the most promising therapeutic targets for breast cancer. However, the anti-proliferation effect of PPARγ agonists on breast ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/502A61K31/426A61P35/00
Inventor 江颖陆维祺张勇朱隽
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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