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Application of panax japonicus extract in preparing medicine of preventing osteoporosis

An anti-osteoporosis and bamboo ginseng technology, applied in drug combinations, bone diseases, pharmaceutical formulations, etc., can solve problems such as limiting the clinical application of estrogen and increasing the risk of endometrial hyperplasia

Active Publication Date: 2013-05-22
杨小林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term use of exogenous estrogen in large quantities will increase the risk of complications such as endometrial hyperplasia, uterine cancer, breast cancer, ovarian cancer, and venous thrombosis, which limits the clinical application of estrogen.

Method used

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  • Application of panax japonicus extract in preparing medicine of preventing osteoporosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 Preparation of bamboo ginseng aqueous extract, bamboo ginseng ethanol extract, bamboo ginseng crude extract (bamboo ginseng total saponins), and bamboo ginseng essence extract (bamboo ginseng saponin V)

[0018] Preparation of bamboo ginseng water extract:

[0019] Take 500g of bamboo ginseng herbal decoction pieces, add water to soak for 2 hours, decoct with 10 times the amount of water on direct fire for 3 times, 2 hours each time, combine the water extracts, concentrate in a water bath to nearly dry, under the negative pressure of 0.08Mpa below 80°C dry to obtain the water extract powder of Panax ginseng. Dissolve the water extract powder of Panax ginseng to a constant volume to an aqueous solution with a concentration of 1g crude drug / mL. It is ready to be diluted to a certain concentration for use in in vivo and in vitro efficacy tests.

[0020] Preparation of Alcoholic Extract of Bamboo Ginseng:

[0021] Take 500g of decoction slices of bamboo ginseng...

Embodiment 2

[0034] Example 2 The in vitro anti-osteoporosis effect of bamboo ginseng water extract, bamboo ginseng ethanol extract, bamboo ginseng crude extract (total saponins of bamboo ginseng) and essence extract of bamboo ginseng (bamboo ginseng saponin V)

[0035] This technical plan uses the in vitro MC3T3-E1 cell model and the in vivo retinoic acid rat osteoporosis model to study the water extract of bamboo ginseng, the alcohol extract of bamboo ginseng, the crude extract of bamboo ginseng (total saponins of bamboo ginseng), Anti-osteoporosis activity of Panax ginseng extract (Phosaphyllum saponin V).

[0036] experiment method:

[0037] MC3T3-E1 cells (MC3T3-E1, purchased from the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences) were 2 × 10 4 The cells / mL density was inoculated in a 96-well culture plate, 200 μL per well, and administered after 24 hours of culture. The experimental group was added the water extract of Panax ginseng and the alcohol extra...

Embodiment 3

[0043] Example 3 Anti-osteoporosis effect of bamboo ginseng extract (water extract, ethanol extract) and bamboo ginseng crude extract (total saponins of bamboo ginseng) in vivo

[0044] Experimental method: Take 72 male SD rats, weighing 150-220g. They were randomly divided into 9 groups according to their body weight. One group was used as the normal control group and was given 0.5% CMC-Na solution, and the rats in the other 8 groups were given 70 mg / kg retinoic acid to prepare the osteoporosis model. Among these 8 groups of rats, one group was given 0.5% CMC-Na solution as the model control group; Low dose group, high and low dose groups of bamboo ginseng alcohol extract, high and low dose groups of bamboo ginseng crude extract (total saponins of bamboo ginseng). After the animals were fed with retinoic acid and medicine for 2 weeks at the same time, the administration of retinoic acid was stopped, and the administration was continued for 2 weeks, once a day. 00 or so to r...

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Abstract

The invention discloses application of panax japonicus extract in preparing medicine of preventing osteoporosis. The panax japonicus extract disclosed by the invention is extracted from natural traditional Chinese medicine panax japonicus; the panax japonicus is a common Chinese herbal medicine. According to the long-term traditional Chinese medicine application experience, the panax japonicus is high in using safety and free of remarkable toxic effects. The panax japonicus extract is remarkable in preventing osteoporosis, free of hepatotoxicity and safer than the existing phosphorus tablet. Therefore, the panax japonicus extract has a prospect of being developed into the medicine of preventing osteoporosis.

Description

Technical field: [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to the application of bamboo ginseng extracts in the preparation of anti-osteoporosis medicines. technical background: [0002] Panax japonicus C.A. Mey., also known as Panax japonicus C.A. Mey., is the dried rhizome of Panax japonicus C.A. Mey. Bamboo ginseng is warm in nature, sweet in taste, slightly bitter; nourishing and strong, dispersing blood stasis, relieving pain, stopping bleeding and eliminating phlegm; used for weakness after illness, cough with hemoptysis, cough with excessive phlegm, and injury from falls. Modern pharmacological studies have shown that the main active ingredients of bamboo ginseng are saponins, and still contain a small amount of volatile oil, polysaccharides and amino acids. [0003] Osteoporosis (OP) is a systemic metabolic bone disease characterized by decreased bone mass, degenerative changes in bone tissue mi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K31/704A61P19/10A61K125/00
Inventor 杨小林
Owner 杨小林
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