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Application of celastrus orbiculatus alcohol extract in preparing medicine for treating non-alcoholic fatty liver disease (NAFLD)

An alcohol and non-alcoholic technology of scutellaria can be applied in the application field of scutellaria, which can solve problems such as difficult adherence of patients, and achieve the effects of reducing sensitivity, simple preparation method, and good treatment of non-alcoholic fatty liver disease.

Inactive Publication Date: 2013-06-12
TAISHAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, calorie restriction and exercise are the only effective means to treat NAFLD, but it is often difficult for most patients to persist. Therefore, it is necessary to find effective drugs for the treatment of NAFLD

Method used

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  • Application of celastrus orbiculatus alcohol extract in preparing medicine for treating non-alcoholic fatty liver disease (NAFLD)
  • Application of celastrus orbiculatus alcohol extract in preparing medicine for treating non-alcoholic fatty liver disease (NAFLD)
  • Application of celastrus orbiculatus alcohol extract in preparing medicine for treating non-alcoholic fatty liver disease (NAFLD)

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Embodiment Construction

[0014] The present invention is described in detail below in conjunction with accompanying drawing and specific embodiment:

[0015] As shown in the figure is a specific embodiment of the present invention,

[0016] (1) Preparation of Alcoholic Extract of S. chinensis and Detection of Active Components

[0017] The cane of the southern snake is collected from Mount Tai and identified by Professor Li Tongde, a senior expert in pharmacology at Taishan Medical College. Grind after drying the vine stem of Snakejae, and dissolve 50g of its powder in 750ml of 55% ethanol overnight. The alcohol extract is filtered and concentrated into extract (11.34g crude drug / g), and then the extract is prepared into 2.5 g crude drug / ml, 5.0g crude drug / ml, 10.0g crude drug / ml with 5% sodium carboxymethylcellulose ml, stored at 4°C for later use. Simultaneously, the total flavonoid content in this extract is measured by ultraviolet spectrophotometer, and its main components rutin, kaempferol, a...

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Abstract

The invention discloses an application of a celastrus orbiculatus alcohol extract in preparing a medicine for treating non-alcoholic fatty liver disease (NAFLD). By adopting a high-fat diet induced guinea pig NAFLD model and taking simvastatin as a positive control medicine, the celastrus orbiculatus alcohol extract is orally taken for 8 weeks, then influence of the celastrus orbiculatus alcohol extract on NAFLD is observed, and a corresponding mechanism is explored; and the result indicates that the celastrus orbiculatus alcohol extract can be used for obviously improving the high-fat induced pathological alteration of liver tissue, easing the damage of liver cells, reducing the lipid accumulation in liver and suppressing oxidative stress reaction in liver. According to the invention, a new application of the celastrus orbiculatus alcohol extract is developed, and a new means of treating NAFLD is provided.

Description

technical field [0001] The present invention relates to the field of application of S. serpentine, in particular to the application of S. serpentine alcohol extract in the preparation of medicaments for treating non-alcoholic fatty liver. Background technique [0002] Non-alcoholic fatty liver disease (NAFLD) has no history of excessive drinking, but histological lesions of the liver have similar clinical symptoms and signs to alcoholic liver disease, and can develop into cirrhosis and liver cancer. In recent years, with the improvement of living standards, the incidence of NAFLD has been increasing year by year. About 14% to 24% of the general population suffer from NAFLD, which has become one of the most common liver diseases. At present, calorie restriction and exercise are the only effective means to treat NAFLD, but it is often difficult for most patients to persist. Therefore, it is necessary to find effective drugs for the treatment of NAFLD. Contents of the inventi...

Claims

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Application Information

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IPC IPC(8): A61K36/37A61P1/16A61K135/00
Inventor 秦树存张颖司艳红
Owner TAISHAN MEDICAL UNIV
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