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Diamino triazine hydrogen bond enhanced hydrogel based on cyclodextrin crosslinking and preparation method and application thereof

A technology of diaminotriazine and cyclodextrin, applied in the field of hydrogel, can solve the problems of limited application and poor mechanical properties, and achieve the effects of improving mechanical properties, high water absorption, easy long-term storage and long-distance transportation

Inactive Publication Date: 2015-07-08
TIANJIN UNIV
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Problems solved by technology

However, for traditional hydrogels, poor mechanical properties limit their applications as biomaterials, especially mechanical devices

Method used

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  • Diamino triazine hydrogen bond enhanced hydrogel based on cyclodextrin crosslinking and preparation method and application thereof
  • Diamino triazine hydrogen bond enhanced hydrogel based on cyclodextrin crosslinking and preparation method and application thereof
  • Diamino triazine hydrogen bond enhanced hydrogel based on cyclodextrin crosslinking and preparation method and application thereof

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Embodiment Construction

[0021] The technical solutions of the present invention will be further described below in conjunction with specific embodiments.

[0022]Among them, polyethylene glycol acrylate (PEGDA) can be directly purchased from Sigma Company of the United States (Mn=526, PEG526MA), and 4 g of polyethylene glycol diimidazole (purchased from Tianjin Kewei Reagent Co., Ltd.) was used to activate 4 g of PEGDA. Alcohol methacrylate, and then add 2g β-cyclodextrin (purchased from Tianjin Kewei Reagent Co., Ltd.) to react for 24 hours, the reaction temperature is 20-25 ° C, using DMSO as the reaction solvent, and the reacted mixture is passed through dialysis and Freeze-dried to obtain the target product PEG526MA-β-CD. figure 2 It is the NMR spectrum of β-cyclodextrin and polyethylene glycol acrylate modified β-cyclodextrin in deuterated DMSO, the instrument used is UNITY plus-500NMRspectrometer (Varian, USA), where δ4.8ppm is cyclodextrin The hydrogen atom directly connected to the No. 1 ca...

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Abstract

The invention discloses a diamino triazine hydrogen bond enhanced hydrogel based on cyclodextrin crosslinking and a preparation method and an application thereof. The diamino triazine hydrogen bond enhanced hydrogel based on cyclodextrin crosslinking is prepared from 2-vinyl-4,6-diamino-1,3,5-triazine and beta-cyclodextrin with double bond through free radical polymerization and copolymerization; the two monomers and an initiator are dissolved in a solvent; unsaturated bonds on the molecules thereof are initiated by the initiator; and the hydrogel is prepared through a free radical polymerization reaction. The hydrogel disclosed by the invention has high stretch resistance and compression resistance and good biocompatibility.

Description

technical field [0001] The present invention relates to the field of hydrogels, more specifically, to high-strength hydrogels with dual functions of drug and gene release and its preparation method, namely β-cyclodextrin and 2-vinyl-4,6-diamino - Preparation of 1,3,5-triazine copolymer (PCD-co-PVDT) hydrogel and its performance as a drug carrier and gene carrier. Background technique [0002] Hydrogel is a kind of polymer with a three-dimensional network structure that uses water as the dispersion medium, can absorb a large amount of water in water and can maintain its original structure without being dissolved. At the same time, it also has good water permeability and biocompatibility, and can be used as a human implant to reduce adverse reactions. Therefore, hydrogels are widely used as excellent biomedical materials. However, for conventional hydrogels, poor mechanical properties limit their applications as biomaterials, especially mechanical devices. In recent years, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F290/10C08F226/06C08B37/16A61K47/40A61K31/192C12N15/63
Inventor 刘文广胡秀凤王宁刘璐
Owner TIANJIN UNIV
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