Content detection method for Naoxintong capsule

A detection method, a brain-to-heart technology, applied to measuring devices, instruments, scientific instruments, etc., can solve the problem of large dosage, achieve strong specificity, increase dissolution speed, and improve separation effect

Active Publication Date: 2013-07-17
SHAANXI BUCHANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Under the content determination item of the current Naoxintong capsule quality standard, only the content of a single index component of paeoniflorin is detected. At the same time, the literature research results of the prior art show that the content determination of this preparation mostly uses the HPLC method, and only a single one of them is often detected. However, there is no report on the determination of multi-flavored drugs and multiple components in Naoxintong capsules.
In addition, the dosage of astragalus, red peony root, salvia miltiorrhiza, angelica, chuanxiong, and safflo

Method used

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  • Content detection method for Naoxintong capsule
  • Content detection method for Naoxintong capsule
  • Content detection method for Naoxintong capsule

Examples

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Embodiment 1

[0012] (1) Astragalus 66g, Radix Paeoniae Rubra 27g, Salvia miltiorrhiza 27g, Angelica 27g, Chuanxiong 27g, peach kernel 27g, safflower 13g, frankincense 13g, myrrh 13g, milletus 20g, achyranthes bidentata 27g, cassia twig 20g, mulberry Take 27g of twigs, 27g of earthworm, 13g of scorpion, and 27g of leeches. Take earthworm and scorpion and grind them into fine powder; the other fourteen herbs such as astragalus are crushed into fine powder, and mix with the powder of earthworm and scorpion. , sieved, mixed evenly, packed into capsules, and made into 1000 capsules to obtain capsules. (2) Take 20 capsules, weigh them accurately, transfer the contents of the capsules completely to a weighing bottle with dry constant weight, and then accurately weigh the empty capsule shells to calculate the average grain weight of the capsules. Precisely weigh about 0.5 g of the contents of the capsule, put it into a 150 mL Erlenmeyer flask with a stopper, add 50 mL of 75% methanol precisely, we...

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Abstract

The invention relates to a content detection method for the Naoxintong capsule. The Naoxintong capsule comprises 66 parts of astragalus root, 27 parts of red peony root, 27 parts of root of red-rooted salvia, 27 parts of Chinese angelica, 27 parts of Szechuan lovage rhizome, 27 parts of peach kernel, 13 parts of safflower, 13 parts of prepared Frankincense, 13 parts of prepared myrrh, 20 parts of suberect spatholobus stem, 27 parts of twotooth achyranthes root, 20 parts of cassia twig, 27 parts of mulberry twig, 27 parts of earthworm, 13 parts of scorpion, and 27 parts of leech. The main chemical components, namely hydroxy safflower yellow A, paeoniflorin, ferulic acid, salvianolic acid B and ligustilide, in the Naoxintong capsule are simultaneously measured by the UPLC (ultra-performance liquid chromatography) technique. Single chromatographic analysis can be completed in 24 minutes. Chromatographic peaks of the main components are well separate, RSD (relative standard deviation) in both precision and receptiveness is smaller than 2.0%, and the quality of Naoxintong capsule can be controlled comprehensively.

Description

technical field [0001] The invention relates to a method for detecting the content of Naoxintong capsules, which belongs to the technical field of pharmaceutical preparations. Background technique [0002] Naoxintong Capsules (commercially available product, the quality standard was disclosed in the "Internal Medicine - Brain System" sub-volume of "National Standards Compilation of Chinese Proprietary Drugs - National Standards of Chinese Proprietary Medicines Rising Local Standards" compiled by the State Drug Administration in 2002, standard No.: WS-10001 (ZD-0001)-2002) is composed of astragalus, red peony root, salvia miltiorrhiza, angelica, chuanxiong, safflower, peach kernel, frankincense (made), myrrh (made), spatholobus, achyranthes bidentata, osmanthus It is a clinically commonly used compound preparation of traditional Chinese medicine made from 16 medicinal materials such as twig, mulberry branch, earthworm, scorpion, and leech. Treatment of middle meridian and ch...

Claims

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Application Information

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IPC IPC(8): G01N30/88
Inventor 李耿吴宏伟付梅红方婧许海玉杨洪军刘峰马久太党艳妮陈衍斌何娟王娟郭剑
Owner SHAANXI BUCHANG PHARMA
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