Content detection method for Naoxintong capsule

Abstract

The invention relates to a content detection method for the Naoxintong capsule. The Naoxintong capsule comprises 66 parts of astragalus root, 27 parts of red peony root, 27 parts of root of red-rooted salvia, 27 parts of Chinese angelica, 27 parts of Szechuan lovage rhizome, 27 parts of peach kernel, 13 parts of safflower, 13 parts of prepared Frankincense, 13 parts of prepared myrrh, 20 parts of suberect spatholobus stem, 27 parts of twotooth achyranthes root, 20 parts of cassia twig, 27 parts of mulberry twig, 27 parts of earthworm, 13 parts of scorpion, and 27 parts of leech. The main chemical components, namely hydroxy safflower yellow A, paeoniflorin, ferulic acid, salvianolic acid B and ligustilide, in the Naoxintong capsule are simultaneously measured by the UPLC (ultra-performance liquid chromatography) technique. Single chromatographic analysis can be completed in 24 minutes. Chromatographic peaks of the main components are well separate, RSD (relative standard deviation) in both precision and receptiveness is smaller than 2.0%, and the quality of Naoxintong capsule can be controlled comprehensively.

Description

technical field [0001] The invention relates to a method for detecting the content of Naoxintong capsules, which belongs to the technical field of pharmaceutical preparations. Background technique [0002] Naoxintong Capsules (commercially available product, the quality standard was disclosed in the "Internal Medicine - Brain System" sub-volume of "National Standards Compilation of Chinese Proprietary Drugs - National Standards of Chinese Proprietary Medicines Rising Local Standards" compiled by the State Drug Administration in 2002, standard No.: WS-10001 (ZD-0001)-2002) is composed of astragalus, red peony root, salvia miltiorrhiza, angelica, chuanxiong, safflower, peach kernel, frankincense (made), myrrh (made), spatholobus, achyranthes bidentata, osmanthus It is a clinically commonly used compound preparation of traditional Chinese medicine made from 16 medicinal materials such as twig, mulberry branch, earthworm, scorpion, and leech. Treatment of middle meridian and ch...

AI Technical Summary

Problems solved by technology

Under the content determination item of the current Naoxintong capsule quality standard, only the content of a single index component of paeoniflorin is detected. At the same time, the literature research results of the prior art show that the content determination of this preparation mostly uses the HPLC method, and only a single one of them is often detected. However, there is no report on the determination of multi-flavored drugs and multiple components in Naoxintong capsules.

In addition, the dosage of astragalus, red peony root, salvia miltiorrhiza, angelica, chuanxiong, and safflower in the prescription is relatively large. It has been reported in the literature that paeoniflorin in red peony root, salvianolic acid B in red sage root, and asafoetida in angelica and chuanxiong The main active ingredients such as acid, ligustilide, and hydroxysafflower yellow A in safflower were determined under different chromatographic conditions, but the content of these ingredients was determined under the same detection process and conditions of a preparation at the same time. The research results have not yet been recorded, and it is worthy of further study by researchers

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